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E2F4 Products

(E2F Transcription Factor 4, P107/p130-Binding (E2F4))

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The protein encoded by this gene is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. The E2F proteins contain several evolutionally conserved domains found in most members of the family. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. This protein binds to all three of the tumor suppressor proteins pRB, p107 and p130, but with higher affinity to the last two. It plays an important role in the suppression of proliferation-associated genes, and its gene mutation and increased expression may be associated with human cancer. [provided by RefSeq, Jul 2008].

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Featured E2F4 Categories

E2F4 Antibodies

High quality antibodies with extensive validation data.

E2F4 Proteins

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended E2F4 Antibodies

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human, Mouse, Rat
Application ELISA, WB, IHC (p)
Validations
  • (5)
Cat. No. ABIN3187838
Quantity 100 μL
Datasheet Datasheet
Reactivity Human, Monkey, Mouse, Rat
Application ELISA, WB, IHC, IF, ICC
Validations
  • (4)
Cat. No. ABIN6261411
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application ELISA, WB
Validations
  • (3)
Cat. No. ABIN560681
Quantity 100 μg
Datasheet Datasheet

Recommended E2F4 ELISA Kits

Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
Cat. No. ABIN6216586
Quantity 96 tests
Datasheet Datasheet

Recommended E2F4 Proteins

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1352239
Quantity 10 μg
Datasheet Datasheet
Reactivity Mouse
Source Escherichia coli (E. coli)
Validations
Cat. No. ABIN2746549
Quantity 5 applications
Datasheet Datasheet

Latest Publications for our E2F4 products

Kanakkanthara, Huntoon, Hou, Zhang, Heinzen, OBrien, Oberg, John Weroha, Kaufmann, Karnitz: "ZC3H18 specifically binds and activates the BRCA1 promoter to facilitate homologous recombination in ovarian cancer." in: Nature communications, Vol. 10, Issue 1, pp. 4632, (2019) (PubMed).

Morillo, Abanto, Román, Frade: "Nerve growth factor-induced cell cycle reentry in newborn neurons is triggered by p38MAPK-dependent E2F4 phosphorylation." in: Molecular and cellular biology, Vol. 32, Issue 14, pp. 2722-37, (2012) (PubMed).

Zhu, Khozoie, Bility, Ferry, Blazanin, Glick, Gonzalez, Peters: "Peroxisome proliferator-activated receptor β/δ cross talks with E2F and attenuates mitosis in HRAS-expressing cells." in: Molecular and cellular biology, Vol. 32, Issue 11, pp. 2065-82, (2012) (PubMed).

Synonyms and alternative names related to E2F4

E2F transcription factor 4 (E2F4), E2F transcription factor 4 (E2f4), E2F transcription factor 4 S homeolog (e2f4.S), E2F transcription factor 4 (e2f4), 2010111M04Rik, AI427446, E2F-4, e2f-4, E2F4, fb72f07, wu:fb72f07, wu:fe05f06, zgc:63815

Protein level used designations for E2F4

  • p107/p130-binding protein
  • transcription factor E2F4
  • E2F-4
  • E2F transcription factor 4, p107/p130-binding
  • E2F transcription factor 4
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