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Browse our FOXO4 Proteins (FOXO4)

Full name:
Forkhead Box O4 Proteins (FOXO4)
On are 3 Forkhead Box O4 (FOXO4) Proteins from 2 different suppliers available. Additionally we are shipping FOXO4 Antibodies (245) and FOXO4 Kits (17) and many more products for this protein. A total of 283 FOXO4 products are currently listed.
afx, AFX1, Afxh, foxo4, Mllt7, RGD1561201
list all proteins Gene Name GeneID UniProt
FOXO4 4303 P98177
FOXO4 54601 Q9WVH3
Rat FOXO4 FOXO4 302415  

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FOXO4 Proteins (FOXO4) by Origin

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More Proteins for FOXO4 Interaction Partners

Human Forkhead Box O4 (FOXO4) interaction partners

  1. FOXO4 has an inhibitory effect in clearcell renal carcinoma cells, at least in part through inducing apoptosis via upregulation of Bim (show BCL2L11 Proteins) in the mitochondria-dependent pathway.

  2. knockdown of Ku70 (show XRCC6 Proteins) inhibited cell proliferation accompanying an increase in p27(kip1 (show CDKN1B Proteins)) levels through interacting with FOXO4

  3. miR (show MLXIP Proteins)-664 functions as an oncogene (show RAB1A Proteins) miRNA and has an important role in promoting human osteosarcoma cell proliferation by suppressing FOXO4 expression.

  4. The data demonstrated that elevated miR (show MLXIP Proteins)-150 targets FOXO4 expression and therefore regulates multiple genes expression, resulting in cervical cancer cell growth and survival.

  5. Porphyromonas gingivalis-induced reactive oxygen species activate FOXO (show FOXO3 Proteins) transcription factors through JNK (show MAPK8 Proteins) signalling, and that FOXO1 (show FOXO1 Proteins) controls oxidative stress responses, inflammatory cytokine production and cell survival.

  6. Cox (show COX8A Proteins) regression analysis indicated FoxO4 to be an independent prognostic factor in non-small cell lung cancers and suggested that FoxO4 might inhibit the process of EMT (show ITK Proteins) in non-small cell lung cancers, and might therefore be a target for therapy.

  7. FOXOs support the metabolic requirements of normal and tumor cells by promoting IDH1 (show IDH1 Proteins) expression.

  8. data strongly suggest that increased PI3K (show PIK3CA Proteins)/AKT (show AKT1 Proteins)-mediated metastatic invasiveness in CaP is associated with FOXO4 loss, and that mechanisms to induce FOXO4 re-expression might suppress CaP metastatic aggressiveness.

  9. study demonstrated that miR (show MLXIP Proteins)-1274a prompted gastric cancer cells growth and migration through dampening FOXO4 expression thus provided a potential target for human gastric cancer therapy

  10. Data indicate that glycogen synthase kinase 3 beta (GSK3beta) and transcription factors FOXO1/3/4 promote hepatoma cell proliferation through type I insulin-like growth factor receptor (IGF-IR).

Mouse (Murine) Forkhead Box O4 (FOXO4) interaction partners

  1. Foxo1 (show FOXO1 Proteins), Foxo3a (show FOXO3 Proteins), and Foxo4 in chondrocytes regulate endochondral bone formation.

  2. The effect of Sirt1 (show SIRT1 Proteins) stimulators on osteoclastogenesis was abrogated in cells lacking FoxO1 (show FOXO1 Proteins), FoxO3 (show FOXO3 Proteins), and FoxO4.

  3. FoxO4 is collectively required to maintain MODYrelated gene networks, which in turn are required to enable a gene expression program that permits proper substrate selection (glucose versus fatty acids) for mitochondrial oxidative phosphorylation.

  4. FoxO4 transcription factor is present during both oocyte and embryo in vivo maturation and FoxOs may regulate in vitro embryo development under stress conditions.

  5. FoxO4 activates Arg1 (show ARG1 Proteins) transcription in endothelial cells in response to MI, leading to downregulation of nitric oxide and upregulation of neutrophil infiltration to the infarct area.

  6. Foxo1, Foxo3, and Foxo4 transcriptional network regulates autophagy and the ubiquitin-proteasome system during muscle atrophy.

  7. Liver-specific ablation of FoxO1 (show FOXO1 Proteins),FoxO3 (show FOXO3 Proteins) and FoxO4 prevents the induction of glucose-6-phosphatase (show G6PC Proteins) and the repression of glucokinase (show GCK Proteins) during fasting, thus increasing lipogenesis.

  8. FOXO1 (show FOXO1 Proteins), FOXO3a (show FOXO3 Proteins) and FOXO4, are indispensable for SIRT1 (show SIRT1 Proteins)-dependent cell survival against oxidative stress.

  9. FoxO1 (show FOXO1 Proteins)/3/4 transcription factors play important roles in hepatic glucose homeostasis.

  10. Mice lacking Foxo1 (show FOXO1 Proteins), -3, and -4 in bipotential progenitors of osteoblast and adipocytes exhibit increased osteoblast number and high bone mass.

FOXO4 Protein Profile

Protein Summary

This gene encodes a member of the O class of winged helix/forkhead transcription factor family. Proteins encoded by this class are regulated by factors involved in growth and differentiation indicating they play a role in these processes. A translocation involving this gene on chromosome X and the homolog of the Drosophila trithorax gene, encoding a DNA binding protein, located on chromosome 11 is associated with leukemia. Multiple transcript variants encoding different isoforms have been found for this gene.

Alternative names and synonyms associated with FOXO4

  • forkhead box O4 (FOXO4)
  • similar to Putative fork head domain transcription factor AFX1 (Forkhead box protein O4) (FOXO4)
  • forkhead box O4 (foxo4)
  • forkhead box O4 (LOC100348179)
  • forkhead box O4 (Foxo4)
  • afx protein
  • AFX1 protein
  • Afxh protein
  • foxo4 protein
  • Mllt7 protein
  • RGD1561201 protein

Protein level used designations for Forkhead Box O4 Proteins (FOXO4)

similar to Putative fork head domain transcription factor AFX1 (Forkhead box protein O4) , forkhead box O4 , forkhead box protein O4-like , fork head domain transcription factor AFX1 , forkhead box protein O4 , myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 7 , forkhead protein , myeloid/lymphoid or mixed lineage-leukemia translocation to 7 homolog , forkhead box O1A

100055869 Equus caballus
698055 Macaca mulatta
100301976 Xenopus laevis
100384968 Callithrix jacchus
100471060 Ailuropoda melanoleuca
100586421 Nomascus leucogenys
100348179 Oryctolagus cuniculus
4303 Homo sapiens
54601 Mus musculus
491946 Canis lupus familiaris
302415 Rattus norvegicus
428703 Gallus gallus
618793 Bos taurus
733705 Sus scrofa
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