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Browse our MDM4-binding Protein Proteins (MDM4)

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Mdm4-binding Protein Proteins (MDM4)
On are 10 Mdm4-binding Protein (MDM4) Proteins from 5 different suppliers available. Additionally we are shipping MDM4-binding Protein Antibodies (141) and MDM4-binding Protein Kits (7) and many more products for this protein. A total of 166 MDM4-binding Protein products are currently listed.
4933417N07Rik, AA414968, AL023055, AU018793, AU021806, C85810, HDMX, Mdmx, MRP1, wu:fa09h09, wu:fi33d10
list all proteins Gene Name GeneID UniProt
MDM4 4194 O15151
MDM4 304798 Q5XIN1
MDM4 17248 O35618

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MDM4-binding Protein Proteins (MDM4) by Origin

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More Proteins for MDM4-binding Protein Interaction Partners

Human Mdm4-binding Protein (MDM4) interaction partners

  1. Data indicate that two single-nucleotide polymorphism (SNPs)rs10900598 and rs4245739, located at 3'-untranslated region (UTR) of double minute 4 protein (MDM4) gene, contribute to clinical outcome of advanced non-small cell lung cancer (NSCLC) patients treated with platinum-based chemotherapy.

  2. These findings suggest that Mdm2 (show MDM2 Proteins) splice isoforms may play critical roles in the regulatory loop of p53 (show TP53 Proteins)/Mdm2 (show MDM2 Proteins)-Mdm4 via a RING domain-mediated biochemical mechanism.

  3. AXL (show AXL Proteins) overexpression or activation through growth arrest-specific 6 (Gas6 (show GAS6 Proteins)) ligand stimulation increases MDMX and MDM2 (show MDM2 Proteins) protein levels and decreases p53 (show TP53 Proteins) activity.

  4. p53 (show TP53 Proteins) stabilization, along with antagonism of its signaling partners, MDM2 (show MDM2 Proteins) and MDMX, is a promising strategy for anticancer targeted therapy. (Review)

  5. identified a novel Her4 (show ERBB4 Proteins)-induced posttranslational modification on MDMX

  6. MDM4 SNP34091 polymorphism may function as a protective factor against cancer risk.

  7. Individuals harboring the MDM4 SNP34091AC/CC genotypes had a significantly elevated risk for serous ovarian cancer, particularly high-grade serous ovarian cancer. No association between SNP34091 genotypes and endometrial cancer risk was observed.

  8. The kinetic and thermodynamic characterization of the MDM2 (show MDM2 Proteins)-MDM4 complex was performed with two complementary approaches: atomic force spectroscopy and surface plasmon resonance.

  9. The combination of MDM2 (show MDM2 Proteins) and MDM4 expression is an independent predictor in patients undergoing radical cystectomy for muscle-invasive bladder cancer.

  10. These results suggest that secondary intermolecular interaction is important in p53 (show TP53 Proteins) regulation by MDMX, which may represent a common phenomenon in complexes containing multidomain proteins.

Zebrafish Mdm4-binding Protein (MDM4) interaction partners

  1. Data indicate that knockdown of the Mdm2 (show MDM2 Proteins) and Mdm4 caused dramatic accumulation of mutant p53 protein (show TP53 Proteins).

  2. crystal structure of N-terminal domain of Mdmx bound to 15-residue p53 (show TP53 Proteins) peptide was determined; structure reveals that although principle features of Mdm2 (show MDM2 Proteins)-p53 (show TP53 Proteins) interaction are preserved, the Mdmx hydrophobic cleft on which the p53 (show TP53 Proteins) peptide binds is altered

Mouse (Murine) Mdm4-binding Protein (MDM4) interaction partners

  1. These findings suggest that Mdm2 (show MDM2 Proteins) splice isoforms may play critical roles in the regulatory loop of p53 (show TP53 Proteins)/Mdm2 (show MDM2 Proteins)-Mdm4 via a RING domain-mediated biochemical mechanism.

  2. both MDM2 (show MDM2 Proteins) and MDMX deletion-caused pancreatic defects are completely rescued by loss of p53 (show TP53 Proteins), verifying the crucial role of the MDM2 (show MDM2 Proteins) and/or MDMX in regulating p53 (show TP53 Proteins) in a spatio-temporal manner during the development, functional maintenance, and related disease progress of endocrine pancreas.

  3. we failed to detect any increase in p53 (show TP53 Proteins) level in mutant oocytes, nor any other apoptotic marker, introgression of this targeted invalidation in p53 (show TP53 Proteins)-/- mice restored the fertility of females. This study is the first to show that Mdm2 (show MDM2 Proteins), but not Mdm4, has a critical role in oocyte survival and would be involved in premature ovarian insufficiency phenotype.

  4. Data show that the Mdm4-p73 (show ARHGAP24 Proteins) axis cannot override the dominant role of p53 (show TP53 Proteins) in development and tumorigenesis and that Mdm4 and p73 (show ARHGAP24 Proteins) interaction during development and tumorigenesis suggests new insight into the role of p53 (show TP53 Proteins) family members.

  5. MDM4/HIPK2 (show HIPK2 Proteins)/p53 (show TP53 Proteins) cytoplasmic assembly uncovers coordinated repression of molecules with anti-apoptotic activity during early DNA damage response.

  6. MDMx degradation associated with neuronal death occurs via caspase (show CASP3 Proteins) activation in neurons, and that the progressive loss of MDMx protein represents a potential mechanism of Abeta (show APP Proteins)-induced neuronal death during disease progression in AD

  7. our results show MDM4-MDM2 (show MDM2 Proteins)/p53 (show TP53 Proteins)-IGF1R (show IGF1R Proteins) as an original regulatory mechanism for CNS regeneration

  8. Increased Mdm4-S mRNA levels might correlate with more aggressive cancers without encoding significant amounts of a potential oncoprotein.

  9. results reveal a novel p53 (show TP53 Proteins)- and Mdm2 (show MDM2 Proteins)-independent oncogenic function of Mdmx that provides new insight into the many cancers that overexpress Mdmx.

  10. both MDM2 (show MDM2 Proteins) and MDMX are required for monitoring p53 (show TP53 Proteins) activity during lens development, and they may function independently or synergistically to control p53 (show TP53 Proteins) and maintain normal lens morphogenesis

MDM4-binding Protein (MDM4) Protein Profile

Protein Summary

This gene encodes a nuclear protein that contains a p53 binding domain at the N-terminus and a RING finger domain at the C-terminus, and shows structural similarity to p53-binding protein MDM2. Both proteins bind the p53 tumor suppressor protein and inhibit its activity, and have been shown to be overexpressed in a variety of human cancers. However, unlike MDM2 which degrades p53, this protein inhibits p53 by binding its transcriptional activation domain. This protein also interacts with MDM2 protein via the RING finger domain, and inhibits the latter's degradation. So this protein can reverse MDM2-targeted degradation of p53, while maintaining suppression of p53 transactivation and apoptotic functions. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene.

Alternative names and synonyms associated with MDM4-binding Protein (MDM4)

  • Mdm4 p53 binding protein homolog (mdm4)
  • Mdm4 p53 binding protein homolog (mouse) (MDM4)
  • Mdm4 p53 binding protein homolog (mouse) (Mdm4)
  • transformed 3T3 cell double minute 4 homolog (mouse) (mdm4)
  • transformed mouse 3T3 cell double minute 4 (Mdm4)
  • 4933417N07Rik protein
  • AA414968 protein
  • AL023055 protein
  • AU018793 protein
  • AU021806 protein
  • C85810 protein
  • HDMX protein
  • Mdmx protein
  • MRP1 protein
  • wu:fa09h09 protein
  • wu:fi33d10 protein

Protein level used designations for Mdm4-binding Protein Proteins (MDM4)

double minute 4 protein , mdm2-like p53-binding protein , p53-binding protein Mdm4 , protein Mdm4 , MDM4-related protein 1 , double minute 4, human homolog of; p53-binding protein , protein Mdmx , Mdm4, transformed 3T3 cell double minute 4, p53 binding protein , double minute 4 homolog , transformed mouse 3T3 cell double minute 4

398466 Xenopus laevis
4194 Homo sapiens
478939 Canis lupus familiaris
514225 Bos taurus
304798 Rattus norvegicus
334932 Danio rerio
17248 Mus musculus
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