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Browse our MDM4-binding Protein Proteins (MDM4)

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Mdm4-binding Protein Proteins (MDM4)
On are 10 Mdm4-binding Protein (MDM4) Proteins from 5 different suppliers available. Additionally we are shipping MDM4-binding Protein Antibodies (131) and MDM4-binding Protein Kits (7) and many more products for this protein. A total of 156 MDM4-binding Protein products are currently listed.
4933417N07Rik, AA414968, AL023055, AU018793, AU021806, C85810, HDMX, Mdmx, MRP1, wu:fa09h09, wu:fi33d10
list all proteins Gene Name GeneID UniProt
MDM4 4194 O15151
MDM4 304798 Q5XIN1
MDM4 17248 O35618

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MDM4-binding Protein Proteins (MDM4) by Origin

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More Proteins for MDM4-binding Protein Interaction Partners

Human Mdm4-binding Protein (MDM4) interaction partners

  1. The phosphate group of pTyr99 imposes extensive steric clashes with the C-terminus of p53 (show TP53 Proteins) peptide and induces a significant lateral shift of the peptide ligand, decreasing the binding affinity of MDMX for p53 (show TP53 Proteins).

  2. CETSA was able to validate stapled peptide binding to Mdm2 (show MDM2 Proteins) and Mdm4.

  3. MDM4/HIPK2 (show HIPK2 Proteins)/p53 (show TP53 Proteins) cytoplasmic assembly uncovers coordinated repression of molecules with anti-apoptotic activity during early DNA damage response.

  4. MDM4 rs4245739 single nucleotide polymorphism contributes to small cell lung cancer risk and support the notion that gene 3'-UTR genetic variants, impacting miRNA-binding, might modify small cell lung cancer susceptibility.

  5. These results identify Mdmx growth dependency in wt p53 (show TP53 Proteins) expressing breast cancer across a range of subtypes. Based on our findings, we propose that Mdmx targeting is an attractive strategy for treating breast cancer harboring wt p53 (show TP53 Proteins)

  6. MDM4 overexpression is related to complex karyotype-acute myeloid leukemia (show BCL11A Proteins) with wild-type TP53 (show TP53 Proteins) and might play a pathogenic role by inhibiting p53 (show TP53 Proteins)-signal pathway.

  7. MDMX exerts oncogenic activity via suppression of RB.

  8. We show using reporter gene assays and endogenous MDM4 expression analyses that miR (show MLXIP Proteins)-191-5p and miR (show MLXIP Proteins)-887 have a specific affinity for the rs4245739 SNP C-allele in prostate cancer

  9. MDM4 mutation identified in a glioma patient was associated with loss of the putative MDM4 target site. Therefore, let-7 binding to MDM4 is implicated in the DNA damage response

  10. Finally, a strong association between the expression of EEF1A2 (show EEF1A2 Proteins), phosphorylated AKT (show AKT1 Proteins) and MDM4 was observed in human HCC (show FAM126A Proteins) samples. Strong activation of the EEF1A2 (show EEF1A2 Proteins)/PI3K (show PIK3CA Proteins)/AKT (show AKT1 Proteins)/mTOR (show FRAP1 Proteins)/MDM4 signaling pathway was observed in HCC (show FAM126A Proteins) patients.

Zebrafish Mdm4-binding Protein (MDM4) interaction partners

  1. Data indicate that knockdown of the Mdm2 (show MDM2 Proteins) and Mdm4 caused dramatic accumulation of mutant p53 protein (show TP53 Proteins).

  2. crystal structure of N-terminal domain of Mdmx bound to 15-residue p53 (show TP53 Proteins) peptide was determined; structure reveals that although principle features of Mdm2 (show MDM2 Proteins)-p53 (show TP53 Proteins) interaction are preserved, the Mdmx hydrophobic cleft on which the p53 (show TP53 Proteins) peptide binds is altered

Mouse (Murine) Mdm4-binding Protein (MDM4) interaction partners

  1. MDM4/HIPK2 (show HIPK2 Proteins)/p53 (show TP53 Proteins) cytoplasmic assembly uncovers coordinated repression of molecules with anti-apoptotic activity during early DNA damage response.

  2. MDMx degradation associated with neuronal death occurs via caspase (show CASP3 Proteins) activation in neurons, and that the progressive loss of MDMx protein represents a potential mechanism of Abeta (show APP Proteins)-induced neuronal death during disease progression in AD

  3. our results show MDM4-MDM2 (show MDM2 Proteins)/p53 (show TP53 Proteins)-IGF1R (show IGF1R Proteins) as an original regulatory mechanism for CNS regeneration

  4. Increased Mdm4-S mRNA levels might correlate with more aggressive cancers without encoding significant amounts of a potential oncoprotein.

  5. results reveal a novel p53 (show TP53 Proteins)- and Mdm2 (show MDM2 Proteins)-independent oncogenic function of Mdmx that provides new insight into the many cancers that overexpress Mdmx.

  6. both MDM2 (show MDM2 Proteins) and MDMX are required for monitoring p53 (show TP53 Proteins) activity during lens development, and they may function independently or synergistically to control p53 (show TP53 Proteins) and maintain normal lens morphogenesis

  7. Decreased Mdm4 levels improves the survival of mice expressing wild-type p53 (show TP53 Proteins), but not that of mice expressing a p53 (show TP53 Proteins) hypomorph lacking the proline-rich domain.

  8. identify Mdm4 as one of these key mRNAs that senses the defects in the spliceosomal machinery and transduces the signal to activate the p53 (show TP53 Proteins) response

  9. The work demonstrates that the ability of MDM4 to enhance p53 (show TP53 Proteins) stability is actually a specific property of MDM4 accomplished upon DNA damage.

  10. Mdm4 was depleted by infecteing with wtHAdV or a mutant virus lacking the E1B (show BCKDHB Proteins)-55K gene (dl 1520).

MDM4-binding Protein (MDM4) Protein Profile

Protein Summary

This gene encodes a nuclear protein that contains a p53 binding domain at the N-terminus and a RING finger domain at the C-terminus, and shows structural similarity to p53-binding protein MDM2. Both proteins bind the p53 tumor suppressor protein and inhibit its activity, and have been shown to be overexpressed in a variety of human cancers. However, unlike MDM2 which degrades p53, this protein inhibits p53 by binding its transcriptional activation domain. This protein also interacts with MDM2 protein via the RING finger domain, and inhibits the latter's degradation. So this protein can reverse MDM2-targeted degradation of p53, while maintaining suppression of p53 transactivation and apoptotic functions. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene.

Alternative names and synonyms associated with MDM4-binding Protein (MDM4)

  • Mdm4 p53 binding protein homolog (mdm4)
  • Mdm4 p53 binding protein homolog (mouse) (MDM4)
  • Mdm4 p53 binding protein homolog (mouse) (Mdm4)
  • transformed 3T3 cell double minute 4 homolog (mouse) (mdm4)
  • transformed mouse 3T3 cell double minute 4 (Mdm4)
  • 4933417N07Rik protein
  • AA414968 protein
  • AL023055 protein
  • AU018793 protein
  • AU021806 protein
  • C85810 protein
  • HDMX protein
  • Mdmx protein
  • MRP1 protein
  • wu:fa09h09 protein
  • wu:fi33d10 protein

Protein level used designations for Mdm4-binding Protein Proteins (MDM4)

double minute 4 protein , mdm2-like p53-binding protein , p53-binding protein Mdm4 , protein Mdm4 , MDM4-related protein 1 , double minute 4, human homolog of; p53-binding protein , protein Mdmx , Mdm4, transformed 3T3 cell double minute 4, p53 binding protein , double minute 4 homolog , transformed mouse 3T3 cell double minute 4

398466 Xenopus laevis
4194 Homo sapiens
478939 Canis lupus familiaris
514225 Bos taurus
304798 Rattus norvegicus
334932 Danio rerio
17248 Mus musculus
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