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anti-Human POT1 Antibodies:
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Lung fibroblasts deficient in Sirt1 (show SIRT1 Antibodies) or treated with a selective Sirt1 (show SIRT1 Antibodies) inhibitor exhibit increased cellular senescence and decreased TPP1 (show TPP1 Antibodies) levels, whereas Sirt1 (show SIRT1 Antibodies) overexpression and pharmacological activation protect against CS-induced TPP1 (show TPP1 Antibodies) reduction and telomeric DNA damage.
Binding of POT1-TPP1 (show TPP1 Antibodies) unfolds telomere secondary structure to assist loading of additional heterodimers.
We found that NEK6 (show NEK6 Antibodies)-mediated phosphorylation of TPP1 (show TPP1 Antibodies) Ser255 in G2/M phase regulates the association between telomerase activity and TPP1 (show TPP1 Antibodies). Furthermore, we found evidence that POT1 negatively regulates TPP1 (show TPP1 Antibodies) phosphorylation because the level of Ser255 phosphorylation was elevated when telomeres were elongated by a POT1 mutant lacking its OB-fold domains
Coats plus is caused by a defect in POT1/CST (show GAL3ST1 Antibodies)-dependent telomere fill-in
Downregulation of Protection of Telomeres 1 expression in myelodysplastic syndromes with 7q deletion.
The conservation between fission yeast Tpz1-Pot1 and human TPP1 (show TPP1 Antibodies)-POT1 interactions resulted in mapping a human melanoma-associated (show ZNF654 Antibodies) POT1 mutation (A532P) to the TPP1 (show TPP1 Antibodies)-POT1 interface.
Missense variant p.R117C is associated with cardiac angiosarcoma in TP-53 (show TP53 Antibodies) negative Li-Fraumeni-like families. Mutation carriers show reduced telomere-bound POT1 levels, abnormally long telomeres and increased telomere fragility.
OB-fold domain 1 of human POT1 recognizes both telomeric and non-telomeric DNA motifs
these data provide a molecular basis by which POT1-TPP1 (show TPP1 Antibodies) increases the processivity of telomerase15. Further, we show that this increased processivity may arise from the dynamic sliding of POT1-TPP1 (show TPP1 Antibodies) that induces fast translocation of telomerase.
Expression of shelterin component POT1 is associated with decreased telomere length and immunity condition in humans with severe aplastic anemia.
This gene is a member of the telombin family and encodes a nuclear protein involved in telomere maintenance. Specifically, this protein functions as a member of a multi-protein complex that binds to the TTAGGG repeats of telomeres, regulating telomere length and protecting chromosome ends from illegitimate recombination, catastrophic chromosome instability, and abnormal chromosome segregation. Increased transcriptional expression of this gene is associated with stomach carcinogenesis and its progression. Alternatively spliced transcript variants have been described.
protection of telomeres 1
, POT1-like telomere end-binding protein
, protection of telomeres 1 homolog
, protection of telomeres protein 1