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Browse our anti-POT1 (POT1) Antibodies

Full name:
anti-Protection of Telomeres 1 Antibodies (POT1)
On are 2 Protection of Telomeres 1 (POT1) Antibodies from 2 different suppliers available. Additionally we are shipping and many more products for this protein. A total of 5 POT1 products are currently listed.
HPOT1, pot1
list all antibodies Gene Name GeneID UniProt
POT1 25913 Q9NUX5

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anti-Human POT1 Antibodies:

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More Antibodies against POT1 Interaction Partners

Human Protection of Telomeres 1 (POT1) interaction partners

  1. Coats plus is caused by a defect in POT1/CST (show GAL3ST1 Antibodies)-dependent telomere fill-in

  2. Downregulation of Protection of Telomeres 1 expression in myelodysplastic syndromes with 7q deletion.

  3. The conservation between fission yeast Tpz1-Pot1 and human TPP1 (show TPP1 Antibodies)-POT1 interactions resulted in mapping a human melanoma-associated (show ZNF654 Antibodies) POT1 mutation (A532P) to the TPP1 (show TPP1 Antibodies)-POT1 interface.

  4. Missense variant p.R117C is associated with cardiac angiosarcoma in TP-53 (show TP53 Antibodies) negative Li-Fraumeni-like families. Mutation carriers show reduced telomere-bound POT1 levels, abnormally long telomeres and increased telomere fragility.

  5. OB-fold domain 1 of human POT1 recognizes both telomeric and non-telomeric DNA motifs

  6. these data provide a molecular basis by which POT1-TPP1 (show TPP1 Antibodies) increases the processivity of telomerase15. Further, we show that this increased processivity may arise from the dynamic sliding of POT1-TPP1 (show TPP1 Antibodies) that induces fast translocation of telomerase.

  7. Expression of shelterin component POT1 is associated with decreased telomere length and immunity condition in humans with severe aplastic anemia.

  8. TMPyP4 (meso-tetra(N-methyl-4-pyridyl)porphine) has been widely used as G-quadruplex binding ligand, which stabilized the G-quadruplex in vitro and in cellulo, resulting in down-regulation of pot1 gene transcription.

  9. the participation of POT1 in the transformation process from MGUS to MM, and provide evidence of this gene as a useful prognostic factor in MM as well as a possible molecular target to design new therapeutic strategies.

  10. Rare missense variants in POT1 predispose to familial cutaneous malignant melanoma.

POT1 Antigen Profile

Antigen Summary

This gene is a member of the telombin family and encodes a nuclear protein involved in telomere maintenance. Specifically, this protein functions as a member of a multi-protein complex that binds to the TTAGGG repeats of telomeres, regulating telomere length and protecting chromosome ends from illegitimate recombination, catastrophic chromosome instability, and abnormal chromosome segregation. Increased transcriptional expression of this gene is associated with stomach carcinogenesis and its progression. Alternatively spliced transcript variants have been described.

Alternative names and synonyms associated with POT1

  • protection of telomeres 1 (pot1) antibody
  • protection of telomeres 1 (LOC100346791) antibody
  • protection of telomeres 1 (POT1) antibody
  • HPOT1 antibody
  • pot1 antibody

Protein level used designations for POT1

protection of telomeres 1 , POT1-like telomere end-binding protein , protection of telomeres 1 homolog , protection of telomeres protein 1

403374 Xenopus laevis
100346791 Oryctolagus cuniculus
25913 Homo sapiens
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