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POT1 Products

(Protection of Telomeres 1 (POT1))
This gene is a member of the telombin family and encodes a nuclear protein involved in telomere maintenance. Specifically, this protein functions as a member of a multi-protein complex that binds to the TTAGGG repeats of telomeres, regulating telomere length and protecting chromosome ends from illegitimate recombination, catastrophic chromosome instability, and abnormal chromosome segregation. Increased transcriptional expression of this gene is associated with stomach carcinogenesis and its progression. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jul 2008].

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Featured POT1 Categories

POT1 Antibodies

High quality antibodies with extensive validation data.

POT1 ELISA Kits

Reliable ELISA kits for a wide range of species.

POT1 Proteins

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended POT1 Antibodies

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Application ELISA, IHC, IF
Validations
  • (3)
Cat. No. ABIN7164998
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Application WB, ELISA
Validations
  • (2)
Cat. No. ABIN565204
Quantity 50 μL
Datasheet Datasheet
Reactivity Human
Application WB
Validations
  • (2)
Cat. No. ABIN5663924
Quantity 100 μL
Datasheet Datasheet

Recommended POT1 ELISA Kits

Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
Cat. No. ABIN6958904
Quantity 96 tests
Datasheet Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
Cat. No. ABIN4972163
Quantity 96 tests
Datasheet Datasheet

Recommended POT1 Proteins

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1315766
Quantity 10 μg
Datasheet Datasheet
Reactivity Human
Source Tobacco (Nicotiana tabacum)
Validations
  • (1)
Cat. No. ABIN3094681
Quantity 1 mg
Datasheet Datasheet
Reactivity Mouse
Source Tobacco (Nicotiana tabacum)
Validations
  • (1)
Cat. No. ABIN3136797
Quantity 1 mg
Datasheet Datasheet

Latest Publications for our POT1 products

Swanson, Baribault, Israel, Bae: "Telomere protein RAP1 levels are affected by cellular aging and oxidative stress." in: Biomedical reports, Vol. 5, Issue 2, pp. 181-187, (2016) (PubMed).

Su, Cheng, Tzeng, Lin, Hsu: "An H2A Histone Isotype, H2ac, Associates with Telomere and Maintains Telomere Integrity." in: PLoS ONE, Vol. 11, Issue 5, pp. e0156378, (2016) (PubMed).

Sishc, Nelson, McKenna, Battaglia, Herndon, Idate, Liber, Bailey: "Telomeres and Telomerase in the Radiation Response: Implications for Instability, Reprograming, and Carcinogenesis." in: Frontiers in oncology, Vol. 5, pp. 257, (2015) (PubMed).

Luo, Feng, Wang, Xu, Zhao, Ma, Jiang, Liu, Huang, Songyang: "Mir-23a induces telomere dysfunction and cellular senescence by inhibiting TRF2 expression." in: Aging cell, Vol. 14, Issue 3, pp. 391-9, (2015) (PubMed).

Ci, Li, Ma, Kong, Zheng, Björkholm, Jia, Xu: "Bortezomib-mediated down-regulation of telomerase and disruption of telomere homeostasis contributes to apoptosis of malignant cells." in: Oncotarget, Vol. 6, Issue 35, pp. 38079-92, (2015) (PubMed).

Choi, Lakamp-Hawley, Kolar, Yan, Borgstahl, Ouellette: "The OB-fold domain 1 of human POT1 recognizes both telomeric and non-telomeric DNA motifs." in: Biochimie, Vol. 115, pp. 17-27, (2015) (PubMed).

Wojdyla, Stone, Sethakorn, Uppada, Devito, Bissonnette, Puri: "T-oligo as an anticancer agent in colorectal cancer." in: Biochemical and biophysical research communications, Vol. 446, Issue 2, pp. 596-601, (2014) (PubMed).

Robles-Espinoza, Harland, Ramsay, Aoude, Quesada, Ding, Pooley, Pritchard, Tiffen, Petljak, Palmer, Symmons, Johansson, Stark, Gartside, Snowden, Montgomery, Martin, Liu, Choi, Makowski, Brown et al.: "POT1 loss-of-function variants predispose to familial melanoma. ..." in: Nature genetics, Vol. 46, Issue 5, pp. 478-81, (2014) (PubMed).

Jullien, Mestre, Roux, Gire: "Eroded human telomeres are more prone to remain uncapped and to trigger a G2 checkpoint response." in: Nucleic acids research, Vol. 41, Issue 2, pp. 900-11, (2013) (PubMed).

Kamranvar, Chen, Masucci: "Telomere dysfunction and activation of alternative lengthening of telomeres in B-lymphocytes infected by Epstein-Barr virus." in: Oncogene, Vol. 32, Issue 49, pp. 5522-30, (2013) (PubMed).

Synonyms and alternative names related to POT1

protection of telomeres 1 (POT1), protection of telomeres 1 L homeolog (pot1.L), protection of telomeres 1A (Pot1a), protection of telomeres 1 (Pot1), 1500031H18Rik, AI851169, DKFZp469P1825, HPOT1, POT1, pot1, Pot1, Pot1a

Protein level used designations for POT1

  • POT1-like telomere end-binding protein
  • protection of telomeres 1 homolog
  • protection of telomeres protein 1
  • POT1 protection of telomeres 1 homolog
  • cPot1
  • single-strand telomeric DNA-binding protein
  • POT1 protection of telomeres 1 homolog (S. pombe)
  • protection of telomeres 1
  • protection of telomeres 1 homolog (S. pombe)
  • protection of telomeres protein 1-like
  • mPot1
  • protection of telomeres 1A
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