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Browse our Topoisomerase II alpha Proteins (TOP2A)

Full name:
Topoisomerase (DNA) II alpha 170kDa Proteins (TOP2A)
On www.antibodies-online.com are 3 Topoisomerase (DNA) II alpha 170kDa (TOP2A) Proteins from 2 different suppliers available. Additionally we are shipping Topoisomerase II alpha Antibodies (212) and Topoisomerase II alpha Kits (22) and many more products for this protein. A total of 239 Topoisomerase II alpha products are currently listed.
Synonyms:
D230016L12Rik, TOP-2, TOP2, TOP2A, TP2A
list all proteins Gene Name GeneID UniProt
TOP2A 21973 Q01320
Rat TOP2A TOP2A 360243 P41516
TOP2A 7153 P11388

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Topoisomerase II alpha Proteins (TOP2A) by Origin

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Mouse (Murine) Topoisomerase (DNA) II alpha 170kDa (TOP2A) interaction partners

  1. Deletion or deficiency of PTEN leads to down regulation of TOP2A, dysfunction of the decatenation checkpoint and incomplete DNA decatenation in G2 and M phases.

  2. Inhibition of DNA topoisomerase II (show TOP2 Proteins) selectively reduces the threat of tumorigenicity

  3. Cohesin removal is a prerequisite for the posterior topoisomerase IIalpha-mediated resolution of persisting catenations between segregating chromatids during anaphase II.

  4. Data show that unfolded protein response (UPR)-induced changes in topoisomerase IIalpha (Topo IIalpha) protein levels are not responsible for resistance to etoposide, and that the PERK plays a Topo IIalpha-independent role in altered sensitivity to the drug.

  5. TOP2beta (show TOP2B Proteins) as a factor involved in regulating granulosa cell genomic integrity and follicle atresia.

  6. Topoisomerase IIa not only contributes to stem-cell transcriptome regulation but also primes developmental genes for subsequent activation upon differentiation.

  7. studies indicate that the ability of TOP2A to prevent DNA entanglement at mitosis requires BAF (show BANF1 Proteins) complexes and suggest that this activity contributes to the role of BAF (show BANF1 Proteins) subunits as tumour suppressors

  8. our data reveal TDP2 (show TDP2 Proteins)-mediated error-free NHEJ as an efficient and accurate mechanism to repair TOP2 (show TOP2 Proteins)-induced DSBs

  9. Results identified topoisomerase IIbeta (Top2beta (show TOP2B Proteins)) as a novel determinant for camptothecin sensitivity.

  10. Top IIbeta might be a down-stream target of Nurr1 (show NR4A2 Proteins), which might influence the processes of axon genesis in dopaminergic neurons via the regulation of TOP IIbeta expression.

Human Topoisomerase (DNA) II alpha 170kDa (TOP2A) interaction partners

  1. during early development, TOP2A is likely to have a role in cell proliferation, whereas TOP2B (show TOP2B Proteins) is expressed in post-mitotic cells and may be important in controlling expression of long genes even at this early stage.

  2. Deletion or deficiency of PTEN leads to down regulation of TOP2A, dysfunction of the decatenation checkpoint and incomplete DNA decatenation in G2 and M phases.

  3. The study is an open label, single arm, phase II study, investigating the efficacy of epirubicin in patients with oxaliplatin refractory colorectal cancer and with a cancer cell TOP2A/CEN-17 ratio >/= 1.5

  4. These studies revealed a relationship between TOP2A and androgen receptor (show AR Proteins) signaling pathway that contributes to prostate cancer progression and confers sensitivity to treatments.

  5. TUBB3 (show TUBB3 Proteins), TOP2A, CYP19A1 (show CYP19A1 Proteins) and CYP2D6 (show CYP2D6 Proteins) gene expression, but not protein expression, was associated with patient survival in breast cancer .

  6. PICH and Topo II (show TOP2 Proteins) cooperate to prevent chromosome missegregation events in mitosis.

  7. Topoisomerase IIalpha, an enzyme essential for resolution of DNA replication intermediates, binds telomeres in a TRF1 (show TERF1 Proteins)-mediated manner.

  8. b-ELE could inhibit the proliferation of HepG-2 cells and interfere with the expression and activity of TOPO I and TOPO IIa

  9. Mutation in TOP2A gene is associated with epithelial ovarian cancer growth and drug resistance.

  10. Patients screened for Top2a and Ezh2 (show EZH2 Proteins) expression would exhibit significant response to a combinational treatment involving low dose etoposide combined with Ezh2 (show EZH2 Proteins) inhibition.

Topoisomerase II alpha (TOP2A) Protein Profile

Protein Summary

This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This nuclear enzyme is involved in processes such as chromosome condensation, chromatid separation, and the relief of torsional stress that occurs during DNA transcription and replication. It catalyzes the transient breaking and rejoining of two strands of duplex DNA which allows the strands to pass through one another, thus altering the topology of DNA. Two forms of this enzyme exist as likely products of a gene duplication event. The gene encoding this form, alpha, is localized to chromosome 17 and the beta gene is localized to chromosome 3. The gene encoding this enzyme functions as the target for several anticancer agents and a variety of mutations in this gene have been associated with the development of drug resistance. Reduced activity of this enzyme may also play a role in ataxia-telangiectasia.

Alternative names and synonyms associated with Topoisomerase II alpha (TOP2A)

  • DNA topoisomerase II, alpha isozyme (TOP2A)
  • DNA topoisomerase II, alpha isozyme (Bm1_08705)
  • topoisomerase (DNA) II alpha (Top2a)
  • topoisomerase (DNA) II alpha 170kDa (TOP2A)
  • topoisomerase (DNA) II beta (Top2b)
  • topoisomersae II (TOPOII)
  • D230016L12Rik protein
  • TOP-2 protein
  • TOP2 protein
  • TOP2A protein
  • TP2A protein

Protein level used designations for TOP2A

DNA topoisomerase II, alpha isozyme , DNA Topoisomerase II alpha , DNA topoisomerase 2-alpha , topoisomerase (DNA) 2 alpha , DNA gyrase , DNA topoisomerase (ATP-hydrolyzing) , DNA topoisomerase II, 170 kD , DNA topoisomeraseII_alpha , DNA topoisomerase 2-beta , DNA topoisomerase II, beta isozyme

GENE ID SPECIES
700707 Macaca mulatta
6096668 Brugia malayi
21973 Mus musculus
360243 Rattus norvegicus
100689304 Cricetulus griseus
7153 Homo sapiens
480525 Canis lupus familiaris
395570 Gallus gallus
787696 Bos taurus
21974 Mus musculus
396917 Sus scrofa
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