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Browse our Topoisomerase II alpha Proteins (TOP2A)

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Topoisomerase (DNA) II alpha 170kDa Proteins (TOP2A)
On are 3 Topoisomerase (DNA) II alpha 170kDa (TOP2A) Proteins from 2 different suppliers available. Additionally we are shipping Topoisomerase II alpha Antibodies (252) and Topoisomerase II alpha Kits (21) and many more products for this protein. A total of 278 Topoisomerase II alpha products are currently listed.
D230016L12Rik, TOP-2, TOP2, TOP2A, TP2A
list all proteins Gene Name GeneID UniProt
TOP2A 21973 Q01320
Rat TOP2A TOP2A 360243 P41516
TOP2A 7153 P11388

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Topoisomerase II alpha Proteins (TOP2A) by Origin

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Mouse (Murine) Topoisomerase (DNA) II alpha 170kDa (TOP2A) interaction partners

  1. We demonstrated that Nup98 (show NUP98 Proteins)-TopIIbeta and Nup98 (show NUP98 Proteins)-SETBP1 (show SETBP1 Proteins) negatively regulate the XPO1 (show XPO1 Proteins)-mediated protein export. Our results will contribute to the understanding of the molecular mechanism by which the Nup98 (show NUP98 Proteins)-fusion proteins induce tumorigenesis.

  2. TOP2 (show TOP2 Proteins) and BAF (show BANF1 Proteins) cooperate to recruit pluripotency factors, which explains some of the instructive roles of BAF (show BANF1 Proteins) complexes.

  3. Deletion or deficiency of PTEN leads to down regulation of TOP2A, dysfunction of the decatenation checkpoint and incomplete DNA decatenation in G2 and M phases.

  4. Inhibition of DNA topoisomerase II (show TOP2 Proteins) selectively reduces the threat of tumorigenicity

  5. Cohesin removal is a prerequisite for the posterior topoisomerase IIalpha-mediated resolution of persisting catenations between segregating chromatids during anaphase II.

  6. Data show that unfolded protein response (UPR)-induced changes in topoisomerase IIalpha (Topo IIalpha) protein levels are not responsible for resistance to etoposide, and that the PERK plays a Topo IIalpha-independent role in altered sensitivity to the drug.

  7. TOP2beta (show TOP2B Proteins) as a factor involved in regulating granulosa cell genomic integrity and follicle atresia.

  8. Topoisomerase IIa not only contributes to stem-cell transcriptome regulation but also primes developmental genes for subsequent activation upon differentiation.

  9. studies indicate that the ability of TOP2A to prevent DNA entanglement at mitosis requires BAF (show BANF1 Proteins) complexes and suggest that this activity contributes to the role of BAF (show BANF1 Proteins) subunits as tumour suppressors

  10. our data reveal TDP2 (show TDP2 Proteins)-mediated error-free NHEJ as an efficient and accurate mechanism to repair TOP2 (show TOP2 Proteins)-induced DSBs

Human Topoisomerase (DNA) II alpha 170kDa (TOP2A) interaction partners

  1. Fbxo28 (show FBXO28 Proteins) regulates topoisomerase IIalpha decatenation activity and plays an important role in maintaining genomic stability.

  2. TOP2A rs471692 was not associated with chemoradiotherapy response, whereas tumor regression, weight loss, clinical stage, and cigarette smoking were independent prognostic predictors for these Chinese patients with non-small cell lung cancer.

  3. we propose that phosphorylation of TOP2A by CDC7 (show CDC7 Proteins)/DBF4 (show DBF4 Proteins) in early S-phase prevents its localization and/or activity at centromeres, and inhibition of TOP2A function could be relevant to prevent premature separation of centromeric DNA.

  4. Data indicate that cortex involvement, lower World Health Organization grade and DNA topoisomerase II (show TOP2 Proteins) positivity were strong predictors for preoperative epileptic seizures.

  5. This study showed that the overexpressions of Ki67 (show MKI67 Proteins), RacGAP1 (show RACGAP1 Proteins), and TOP2a affect the prognosis of female breast cancer patients adversely

  6. TOP2A is highly expressed in advanced leiomyosarcoma (LMS)but not in non-malignant diseases. TOP2A levels are higher in high-mitotic index tumours and in more advanced stages of disease.

  7. TOP2a involvement in breast cancer cells apoptosis

  8. HER2 (show ERBB2 Proteins) amplification, but not TOP2A amplification, is a predictor of unfavorable prognosis in breast cancer.

  9. TOP2A and Ki-67 (show MKI67 Proteins) antibodies may be used in combination for cervical cancer screening in immunocytochemistry assays.

  10. The combined quantum and molecular mechanics calculations revealed that CF3 (show F3 Proteins) containing drug shows better preference in inhibiting the TOP2A compared to other modified drugs.

Topoisomerase II alpha (TOP2A) Protein Profile

Protein Summary

This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This nuclear enzyme is involved in processes such as chromosome condensation, chromatid separation, and the relief of torsional stress that occurs during DNA transcription and replication. It catalyzes the transient breaking and rejoining of two strands of duplex DNA which allows the strands to pass through one another, thus altering the topology of DNA. Two forms of this enzyme exist as likely products of a gene duplication event. The gene encoding this form, alpha, is localized to chromosome 17 and the beta gene is localized to chromosome 3. The gene encoding this enzyme functions as the target for several anticancer agents and a variety of mutations in this gene have been associated with the development of drug resistance. Reduced activity of this enzyme may also play a role in ataxia-telangiectasia.

Alternative names and synonyms associated with Topoisomerase II alpha (TOP2A)

  • DNA topoisomerase II, alpha isozyme (TOP2A)
  • DNA topoisomerase II, alpha isozyme (Bm1_08705)
  • topoisomerase (DNA) II alpha (Top2a)
  • topoisomerase (DNA) II alpha 170kDa (TOP2A)
  • topoisomerase (DNA) II beta (Top2b)
  • topoisomersae II (TOPOII)
  • D230016L12Rik protein
  • TOP-2 protein
  • TOP2 protein
  • TOP2A protein
  • TP2A protein

Protein level used designations for TOP2A

DNA topoisomerase II, alpha isozyme , DNA Topoisomerase II alpha , DNA topoisomerase 2-alpha , topoisomerase (DNA) 2 alpha , DNA gyrase , DNA topoisomerase (ATP-hydrolyzing) , DNA topoisomerase II, 170 kD , DNA topoisomeraseII_alpha , DNA topoisomerase 2-beta , DNA topoisomerase II, beta isozyme

700707 Macaca mulatta
6096668 Brugia malayi
21973 Mus musculus
360243 Rattus norvegicus
100689304 Cricetulus griseus
7153 Homo sapiens
480525 Canis lupus familiaris
395570 Gallus gallus
787696 Bos taurus
21974 Mus musculus
396917 Sus scrofa
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