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HAP1 co-localizes with synapsin I (show SYN1 Proteins) in cortical neurons as discrete puncta
Suppression of Ape1/Ref-1 (show APEX1 Proteins) redox function leads to an increased cell surface retention of IL-12 (show IL12A Proteins) and enhances Th1 (show HAND1 Proteins) responses.
findings suggest that Hap1 is important for insulin (show INS Proteins) secretion of pancreatic beta-cells via regulating the intracellular trafficking and plasma membrane localization of Cav1.2 (show CACNA1C Proteins), providing new insight into the mechanisms that regulate insulin (show INS Proteins) release from pancreatic beta-cells.
Is closely associated with upregulation of the Ref1 (show THOC4 Proteins)/Nrf2 (show NFE2L2 Proteins) signalling pathway.
Results show the stimulatory effect of PARP-1 (show PARP1 Proteins) on APE1 (show APEX1 Proteins)-dependent base excision repair (BER). PARP-1 (show PARP1 Proteins) and APE1 (show APEX1 Proteins) appear to have a functional interaction in BER since PARP-1 (show PARP1 Proteins) can stimulate the strand incision activity of APE1 (show APEX1 Proteins).
Early loss of Hap1 significantly reduces postnatal hippocampal neurogenesis, and leads to adult depressive-like behavior.
Hap1 interacts with Bcr (show BCR Proteins) on microtubules to regulate neuronal differentiation.
increases in APEX1 (show APEX1 Proteins) level confer protection against the murine paternal age effect, thus highlighting the role of APEX1 (show APEX1 Proteins) in preserving reproductive health with increasing age and in protection against genotoxin-induced mutagenesis in somatic cells
Endothelial cell tumor proliferation was found to be dependent on Apex-1 (show APEX1 Proteins) expression.
Expression of OGG1 (show OGG1 Proteins) and APEX1 (show APEX1 Proteins) was decreased at 3h after last exposure to Aroclor 1254 and only the expression level of APEX1 (show APEX1 Proteins) was recovered at 24-h after, so inhibition of DNA repair can be a potential mode of action of Aroclor 1254 gonadal toxicity.
data fully support that HAP1 (show APEX1 Proteins) is a GKAP (show DLGAP1 Proteins), anchoring specifically to the cGMP-dependent protein kinase (show CDK7 Proteins) isoform Ibeta, and provide further evidence that also PKG (show PRKG1 Proteins) spatiotemporal signaling is largely controlled by anchoring proteins
HAP1 (show APEX1 Proteins) gene expression is related to the radiosensitivity of breast cancer cells and may play an important role in the regulation of cellular radiosensitivity
Overexpression of HAP1 (show APEX1 Proteins) reduced in vitro cell growth in breast cancer cell lines.
The results of this study found no association was found between the HAP1 (show APEX1 Proteins) T441M polymorphism and the age at onset of Huntington's disease .
The results of this study suggested that HAP1 (show APEX1 Proteins) co-localizes and associates with APP (show APP Proteins) in physiological conditions of mouse and human brain.
WT HTT (show HTT Proteins) regulates ciliogenesis by interacting through huntingtin-associated protein 1 (HAP1) with pericentriolar material 1 protein (PCM1 (show PCM1 Proteins)).
HAP1 (show APEX1 Proteins)/stigmoid body interacts with the normal ataxin-3 (show ATXN3 Proteins) through Josephin (show ATXN3 Proteins) domain
sortilin (show SORT1 Proteins) stabilizes the proBDNF.HAP1 complex
ADORA2A (show ADORA2A Proteins), but not HAP1 (show APEX1 Proteins) or OGG1 (show OGG1 Proteins), may have a role in age at onset in Huntington's disease
REVIEW: function of HAP1 (show APEX1 Proteins)
Huntington's disease (HD), a neurodegenerative disorder characterized by loss of striatal neurons, is caused by an expansion of a polyglutamine tract in the HD protein huntingtin. This gene encodes a protein that interacts with huntingtin, with two cytoskeletal proteins (dynactin and pericentriolar autoantigen protein 1), and with a hepatocyte growth factor-regulated tyrosine kinase substrate. The interactions with cytoskeletal proteins and a kinase substrate suggest a role for this protein in vesicular trafficking or organelle transport. Several alternatively spliced transcript variants encoding different isoforms have been described for this gene.
AP endonuclease 1
, APEX nuclease
, DNA-(apurinic or apyrimidinic site) lyase
, apurinic-apyrimidinic endonuclease 1
, redox factor-1
, huntingtin-associated protein 2
, neuroan 1
, huntingtin-associated protein 1 (neuroan 1)