HAP1 Products
(Huntingtin Associated Protein 1 (HAP1))
Categories
Huntington's disease (HD), a neurodegenerative disorder characterized by loss of striatal neurons, is caused by an expansion of a polyglutamine tract in the HD protein huntingtin. This gene encodes a protein that interacts with huntingtin, with two cytoskeletal proteins (dynactin and pericentriolar autoantigen protein 1), and with a hepatocyte growth factor-regulated tyrosine kinase substrate. The interactions with cytoskeletal proteins and a kinase substrate suggest a role for this protein in vesicular trafficking or organelle transport. Several alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008].
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Featured HAP1 Categories
HAP1 Antibodies
High quality antibodies with extensive validation data.
HAP1 ELISA Kits
Reliable ELISA kits for a wide range of species.
HAP1 Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended HAP1 Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Rat
Application
WB, IHC, IP, IHC (p), IHC (fro)
Validations
- (2)
- (2)
Cat. No.
ABIN534035
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, ELISA, IHC
Validations
- (2)
Cat. No.
ABIN334416
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Mouse
Application
WB, IHC, ICC
Validations
- (3)
Cat. No.
ABIN5013715
Quantity
100 μL
Datasheet
Datasheet
Recommended HAP1 ELISA Kits
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6956609
Quantity
96 tests
Datasheet
Datasheet
Recommended HAP1 Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Tobacco (Nicotiana tabacum)
Validations
- (1)
Cat. No.
ABIN3092885
Quantity
1 mg
Datasheet
Datasheet
Reactivity
Mouse
Source
Tobacco (Nicotiana tabacum)
Validations
- (1)
Cat. No.
ABIN3131645
Quantity
1 mg
Datasheet
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
Cat. No.
ABIN7409197
Quantity
100 μg
Datasheet
Datasheet
Latest Publications for our HAP1 products
: "DYRK1A regulates Hap1-Dcaf7/WDR68 binding with implication for delayed growth in Down syndrome." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 114, Issue 7, pp. E1224-E1233, (2017) (PubMed).: "Huntingtin-associated protein 1 (HAP1) is a cGMP-dependent kinase anchoring protein (GKAP) specific for the cGMP-dependent protein kinase Iβ isoform." in: The Journal of biological chemistry, Vol. 290, Issue 12, pp. 7887-96, (2015) (PubMed).
: "Alterations in the cerebellar (Phospho)proteome of a cyclic guanosine monophosphate (cGMP)-dependent protein kinase knockout mouse." in: Molecular & cellular proteomics : MCP, Vol. 13, Issue 8, pp. 2004-16, (2014) (PubMed).
: "Huntingtin mediates dendritic transport of ?-actin mRNA in rat neurons." in: Scientific reports, Vol. 1, pp. 140, (2012) (PubMed).
: "Huntington's disease: from huntingtin function and dysfunction to therapeutic strategies." in: Cellular and molecular life sciences : CMLS, Vol. 63, Issue 22, pp. 2642-60, (2006) (PubMed).
: "Regulation of intracellular trafficking of huntingtin-associated protein-1 is critical for TrkA protein levels and neurite outgrowth." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 26, Issue 22, pp. 6019-30, (2006) (PubMed).
: "Huntingtin-associated protein 1 (HAP1) interacts with androgen receptor (AR) and suppresses SBMA-mutant-AR-induced apoptosis." in: Human molecular genetics, Vol. 15, Issue 15, pp. 2298-312, (2006) (PubMed).
: "Huntingtin controls neurotrophic support and survival of neurons by enhancing BDNF vesicular transport along microtubules." in: Cell, Vol. 118, Issue 1, pp. 127-38, (2004) (PubMed).
: "Stigmoid bodies contain type I receptor proteins SorLA/LR11 and sortilin: new perspectives on their function." in: The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society, Vol. 51, Issue 6, pp. 841-52, (2003) (PubMed).
: "Complete sequencing and characterization of 21,243 full-length human cDNAs. ..." in: Nature genetics, Vol. 36, Issue 1, pp. 40-5, (2003) (PubMed).
Synonyms and alternative names related to HAP1
huntingtin associated protein 1 (HAP1), huntingtin-associated protein 1 (Hap1), HAP-1, HAP1-A, HAP1-B, HAP2, hHLP1, HIP5, HLPProtein level used designations for HAP1
- HAP-1
- huntingtin-associated protein 2
- neuroan 1
- huntingtin-associated protein 1 (neuroan 1)
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