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Browse our anti-Histone Deacetylase 8 (HDAC8) Antibodies

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anti-Histone Deacetylase 8 Antibodies (HDAC8)
On are 165 Histone Deacetylase 8 (HDAC8) Antibodies from 27 different suppliers available. Additionally we are shipping Histone Deacetylase 8 Proteins (24) and Histone Deacetylase 8 Kits (14) and many more products for this protein. A total of 218 Histone Deacetylase 8 products are currently listed.
2610007D20Rik, ATHDA8, CDLS5, HD8, HDA8, HDACL1, histone deacetylase 8, MRXS6, RGD1562895, RPD3, T27G7.14, T27G7_14, WTS, wu:fd19a02, zgc:66196
list all antibodies Gene Name GeneID UniProt
HDAC8 55869 Q9BY41
HDAC8 70315 Q8VH37
HDAC8 363481 B1WC68

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Top referenced anti-Histone Deacetylase 8 Antibodies

  1. Human Polyclonal HDAC8 Primary Antibody for EIA, IHC (p) - ABIN356653 : McDonell, Ramser, Francis, Vinet, Rider, Sudbrak, Riesselman, Yaspo, Reinhardt, Monaco, Ross, Kahn, Kearney, Buckle, Chelly: Characterization of a highly complex region in Xq13 and mapping of three isodicentric breakpoints associated with preleukemia. in Genomics 2000 (PubMed)
    Show all 4 references for ABIN356653

  2. Human Polyclonal HDAC8 Primary Antibody for IHC (p), WB - ABIN387958 : Hu, Chen, Fredrickson, Zhu, Kirkpatrick, Zhang, Johanson, Sung, Liu, Winkler: Cloning and characterization of a novel human class I histone deacetylase that functions as a transcription repressor. in The Journal of biological chemistry 2000 (PubMed)
    Show all 2 references for ABIN387958

  3. Human Polyclonal HDAC8 Primary Antibody for IF, IHC - ABIN871411 : Lee, Rezai-Zadeh, Seto: Negative regulation of histone deacetylase 8 activity by cyclic AMP-dependent protein kinase A. in Molecular and cellular biology 2003 (PubMed)

  4. Cow (Bovine) Polyclonal HDAC8 Primary Antibody for WB - ABIN2775889 : Balasubramanian, Ramos, Luo, Sirisawad, Verner, Buggy: A novel histone deacetylase 8 (HDAC8)-specific inhibitor PCI-34051 induces apoptosis in T-cell lymphomas. in Leukemia 2008 (PubMed)

  5. Human Polyclonal HDAC8 Primary Antibody for IP, IHC - ABIN223303 : Mao, Hou, Cao, Wang, Li, Chen, Fei, Hurren, Gronda, Wu, Trudel, Schimmer: The tricyclic antidepressant amitriptyline inhibits D-cyclin transactivation and induces myeloma cell apoptosis by inhibiting histone deacetylases: in vitro and in silico evidence. in Molecular pharmacology 2011 (PubMed)

More Antibodies against Histone Deacetylase 8 Interaction Partners

Human Histone Deacetylase 8 (HDAC8) interaction partners

  1. HDAC8 were overexpressed in oral squamous cell carcinoma tissues, mainly localized in the cytoplasm.

  2. Study reveals that HDAC8 can bind and catalyze deacetylation of many acetylated peptides with sequences corresponding to cellular, non-histone proteins, thereby opening a new window to the functional role of HDAC8 in cells.

  3. Findings suggest the therapeutic potential of histone deacetylase 8 histone (HDAC8)inhibition to suppress Notch1 (show NOTCH1 Antibodies) signaling in breast cancer.

  4. Data show that histone deacetylase 8 (HDAC8) inhibition led to accumulation of acetylated-SMC3 (show SMC3 Antibodies) protein but had no influence on the transcription of estrogen-responsive genes.

  5. study elucidates an HDAC8-mediated p53 (show TP53 Antibodies)-inactivating mechanism promoting leukemia stem cells activity

  6. Studies indicate that histone deacetylase 8 protein (HDAC8) aberrantly deacetylates p53 (show TP53 Antibodies) protein and promotes leukemia stem cells (LSCs) transformation and maintenance.

  7. Our data exhibited an important role of HDAC8 in promoting gastric cancer tumorigenesis and identify this HDAC8 as a potential therapeutic target for the treatment of gastric cancer.

  8. The H143A and H142A/H143A mutants exhibit activity that is >80000-fold lower than that of wild-type HDAC8; the buried D176N and D176A mutants have significant catalytic effects, with more subtle effects caused by D183N and D183A

  9. cAMP signaling increases HDAC8 protein levels by reducing JNK (show MAPK8 Antibodies)-mediated autophagy and ubiquitin-proteasome-dependent degradation of the HDAC8 protein in H1299 lung cancer cells.

  10. Report the preparation and biophysical evaluation of five HDAC8 mutants: P91L, G117E, H180R, D233G, and G304R. Additionally, the double mutants D233G-Y306F and P91L-Y306F were prepared to enable cocrystallization of intact enzyme-substrate complexes.

Mouse (Murine) Histone Deacetylase 8 (HDAC8) interaction partners

  1. this study demonstrates a novel role of HDAC8 in LeTx immunotoxicity and regulation of pro-IL-1beta (show IL1B Antibodies) production likely through eRNAs.

  2. findings show how HDAC8 drives nonalcoholic fatty liver disease-associated hepatocarcinogenesis

  3. Data reveal a role for miR (show MLXIP Antibodies)-21-3p in regulating HDAC8 expression and Akt (show AKT1 Antibodies)/Gsk3beta (show GSK3b Antibodies) pathway in cardiac hypertrophy.

  4. histone deacetylase 8 inhibition reduces gene expression and production of proinflammatory cytokines in vitro and in vivo

  5. HDAC8 and Sirt1 (show SIRT1 Antibodies) were also demonstrated to interact directly with ERRalpha (show ESRRA Antibodies) in vivo and to deacetylate and increase the DNA binding affinity of ERRalpha (show ESRRA Antibodies) in vitro.

  6. Global deletion of Hdac8 in mice leads to perinatal lethality due to skull instability, and deletion of Hdac8 in cranial neural crest cells and Hdac8 specifically represses the aberrant expression of homeobox (show PRRX1 Antibodies) transcription factors such as Otx2 (show OTX2 Antibodies) and Lhx1 (show LHX1 Antibodies)

Histone Deacetylase 8 (HDAC8) Antigen Profile

Antigen Summary

Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to class I of the histone deacetylase family. It catalyzes the deacetylation of lysine residues in the histone N-terminal tails and represses transcription in large multiprotein complexes with transcriptional co-repressors. Multiple transcript variants encoding different isoforms have been found for this gene.

Alternative names and synonyms associated with Histone Deacetylase 8 (HDAC8)

  • histone deacetylase 8 (CC1G_05302) antibody
  • histone deacetylase 8 (hdac8) antibody
  • histone deacetylase 8 (HDAC8) antibody
  • histone deacetylase 8 (Hdac8) antibody
  • histone deacetylase 8 (HDA08) antibody
  • 2610007D20Rik antibody
  • ATHDA8 antibody
  • CDLS5 antibody
  • HD8 antibody
  • HDA8 antibody
  • HDACL1 antibody
  • histone deacetylase 8 antibody
  • MRXS6 antibody
  • RGD1562895 antibody
  • RPD3 antibody
  • T27G7.14 antibody
  • T27G7_14 antibody
  • WTS antibody
  • wu:fd19a02 antibody
  • zgc:66196 antibody

Protein level used designations for HDAC8

histone deacetylase 8 , histone deacetylase-like 1 , HD8

6017058 Coprinopsis cinerea okayama7130
100145561 Xenopus (Silurana) tropicalis
55869 Homo sapiens
70315 Mus musculus
363481 Rattus norvegicus
406740 Danio rerio
444137 Xenopus laevis
540666 Bos taurus
480957 Canis lupus familiaris
422182 Gallus gallus
100721893 Cavia porcellus
837366 Arabidopsis thaliana
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