Browse our anti-Histone Deacetylase 8 (HDAC8) Antibodies

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anti-Histone Deacetylase 8 Antibodies (HDAC8)
On are 166 Histone Deacetylase 8 (HDAC8) Antibodies from 29 different suppliers available. Additionally we are shipping Histone Deacetylase 8 Proteins (24) and Histone Deacetylase 8 Kits (15) and many more products for this protein. A total of 220 Histone Deacetylase 8 products are currently listed.
2610007D20Rik, ATHDA8, CDLS5, HD8, HDA8, HDACL1, histone deacetylase 8, MRXS6, RGD1562895, RPD3, T27G7.14, T27G7_14, WTS, wu:fd19a02, zgc:66196
list all antibodies Gene Name GeneID UniProt
HDAC8 55869 Q9BY41
HDAC8 70315 Q8VH37
HDAC8 363481 B1WC68

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Top referenced anti-Histone Deacetylase 8 Antibodies

  1. Human Polyclonal HDAC8 Primary Antibody for EIA, IHC (p) - ABIN356653 : McDonell, Ramser, Francis, Vinet, Rider, Sudbrak, Riesselman, Yaspo, Reinhardt, Monaco, Ross, Kahn, Kearney, Buckle, Chelly: Characterization of a highly complex region in Xq13 and mapping of three isodicentric breakpoints associated with preleukemia. in Genomics 2000 (PubMed)
    Show all 4 references for 356653

  2. Human Polyclonal HDAC8 Primary Antibody for IHC (p), WB - ABIN387958 : Hu, Chen, Fredrickson, Zhu, Kirkpatrick, Zhang, Johanson, Sung, Liu, Winkler: Cloning and characterization of a novel human class I histone deacetylase that functions as a transcription repressor. in The Journal of biological chemistry 2000 (PubMed)
    Show all 2 references for 387958

  3. Cow (Bovine) Polyclonal HDAC8 Primary Antibody for WB - ABIN2775889 : Balasubramanian, Ramos, Luo, Sirisawad, Verner, Buggy: A novel histone deacetylase 8 (HDAC8)-specific inhibitor PCI-34051 induces apoptosis in T-cell lymphomas. in Leukemia 2008 (PubMed)

  4. Human Polyclonal HDAC8 Primary Antibody for IF, IHC - ABIN871411 : Lee, Rezai-Zadeh, Seto: Negative regulation of histone deacetylase 8 activity by cyclic AMP-dependent protein kinase A. in Molecular and cellular biology 2003 (PubMed)

  5. Human Polyclonal HDAC8 Primary Antibody for IP, IHC - ABIN223303 : Mao, Hou, Cao, Wang, Li, Chen, Fei, Hurren, Gronda, Wu, Trudel, Schimmer: The tricyclic antidepressant amitriptyline inhibits D-cyclin transactivation and induces myeloma cell apoptosis by inhibiting histone deacetylases: in vitro and in silico evidence. in Molecular pharmacology 2011 (PubMed)

More Antibodies against Histone Deacetylase 8 Interaction Partners

Human Histone Deacetylase 8 (HDAC8) interaction partners

  1. The findings suggest that miR (show MLXIP Antibodies)-455-3p plays a critical role during chondrogenesis by directly targeting HDAC2 (show HDAC2 Antibodies)/8 and promoting histone H3 (show HIST3H3 Antibodies) acetylation.

  2. 7-amino-4-methylcoumarin did not affect acetyllysine preference in a multiply acetylated substrate. In contrast, AMC significantly enhanced KDAC6 substrate affinity, greatly reduced Sirt1 (show SIRT1 Antibodies) activity, eliminated the substrate sequence specificity of KDAC4, and had no consistent effect with KDAC8 substrates.

  3. Enzymological, biophysical, and structural studies of Cornelia de Lange Syndrome HDAC8 protein mutants have yielded critical insight on compromised catalysis in vitro. Most CdLS (show NIPBL Antibodies) HDAC8 mutations trigger structural changes that directly or indirectly impact substrate binding and catalysis.

  4. class I HDACs (HDAC1 (show HDAC1 Antibodies), 2, 3 and 8) play a major role in regulating extracellular matrix and Epithelial-mesenchymal transition, whereas class IIa HDACs (HDAC4 (show HDAC4 Antibodies) and 5) are less effective.

  5. Losses of catalytic efficiency in histone deacetylase 8 (HDAC8) are observed for G304A and G305A mutations.

  6. Data suggest sequencing of histone deacetylase 8 protein (HDAC8) as an indispensable part of the routine molecular diagnostic for patients with Cornelia de Lange syndrome (CdLS (show NIPBL Antibodies)) or CdLS (show NIPBL Antibodies)-overlapping features.

  7. HDAC8 were overexpressed in oral squamous cell carcinoma tissues, mainly localized in the cytoplasm.

  8. Study reveals that HDAC8 can bind and catalyze deacetylation of many acetylated peptides with sequences corresponding to cellular, non-histone proteins, thereby opening a new window to the functional role of HDAC8 in cells.

  9. Findings suggest the therapeutic potential of histone deacetylase 8 histone (HDAC8)inhibition to suppress Notch1 (show NOTCH1 Antibodies) signaling in breast cancer.

  10. Data show that histone deacetylase 8 (HDAC8) inhibition led to accumulation of acetylated-SMC3 (show SMC3 Antibodies) protein but had no influence on the transcription of estrogen-responsive genes.

Mouse (Murine) Histone Deacetylase 8 (HDAC8) interaction partners

  1. The findings suggest that miR (show MLXIP Antibodies)-455-3p plays a critical role during chondrogenesis by directly targeting HDAC2 (show HDAC2 Antibodies)/8 and promoting histone H3 (show HIST3H3 Antibodies) acetylation.

  2. this study demonstrates a novel role of HDAC8 in LeTx immunotoxicity and regulation of pro-IL-1beta (show IL1B Antibodies) production likely through eRNAs.

  3. findings show how HDAC8 drives nonalcoholic fatty liver disease-associated hepatocarcinogenesis

  4. Data reveal a role for miR (show MLXIP Antibodies)-21-3p in regulating HDAC8 expression and Akt (show AKT1 Antibodies)/Gsk3beta (show GSK3b Antibodies) pathway in cardiac hypertrophy.

  5. histone deacetylase 8 inhibition reduces gene expression and production of proinflammatory cytokines in vitro and in vivo

  6. HDAC8 and Sirt1 (show SIRT1 Antibodies) were also demonstrated to interact directly with ERRalpha (show ESRRA Antibodies) in vivo and to deacetylate and increase the DNA binding affinity of ERRalpha (show ESRRA Antibodies) in vitro.

  7. Global deletion of Hdac8 in mice leads to perinatal lethality due to skull instability, and deletion of Hdac8 in cranial neural crest cells and Hdac8 specifically represses the aberrant expression of homeobox (show PRRX1 Antibodies) transcription factors such as Otx2 (show OTX2 Antibodies) and Lhx1 (show LHX1 Antibodies)

Histone Deacetylase 8 (HDAC8) Antigen Profile

Antigen Summary

Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to class I of the histone deacetylase family. It catalyzes the deacetylation of lysine residues in the histone N-terminal tails and represses transcription in large multiprotein complexes with transcriptional co-repressors. Multiple transcript variants encoding different isoforms have been found for this gene.

Alternative names and synonyms associated with Histone Deacetylase 8 (HDAC8)

  • histone deacetylase 8 (CC1G_05302) antibody
  • histone deacetylase 8 (hdac8) antibody
  • histone deacetylase 8 (HDAC8) antibody
  • histone deacetylase 8 (Hdac8) antibody
  • histone deacetylase 8 (HDA08) antibody
  • 2610007D20Rik antibody
  • ATHDA8 antibody
  • CDLS5 antibody
  • HD8 antibody
  • HDA8 antibody
  • HDACL1 antibody
  • histone deacetylase 8 antibody
  • MRXS6 antibody
  • RGD1562895 antibody
  • RPD3 antibody
  • T27G7.14 antibody
  • T27G7_14 antibody
  • WTS antibody
  • wu:fd19a02 antibody
  • zgc:66196 antibody

Protein level used designations for HDAC8

histone deacetylase 8 , histone deacetylase-like 1 , HD8

6017058 Coprinopsis cinerea okayama7130
100145561 Xenopus (Silurana) tropicalis
55869 Homo sapiens
70315 Mus musculus
363481 Rattus norvegicus
406740 Danio rerio
444137 Xenopus laevis
540666 Bos taurus
480957 Canis lupus familiaris
422182 Gallus gallus
100721893 Cavia porcellus
837366 Arabidopsis thaliana
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