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Mouse (Murine) CX3CR1 ELISA Kit for Sandwich ELISA - ABIN424896
Becker, Holthoff, Anthoni, Rijcken, Alexander, Gavins, Spiegel, Senninger, Vowinkel: Downregulation of CX3CR1 ameliorates experimental colitis: evidence for CX3CL1-CX3CR1-mediated immune cell recruitment. in International journal of colorectal disease 2016
Human CX3CR1 ELISA Kit for Sandwich ELISA - ABIN367268
Zhang, Liu, Su, Shi, Chen: Serum fractalkine and interferon-gamma inducible protein-10 concentrations are early detection markers for acute renal allograft rejection. in Transplantation proceedings 2014
CX3CR1 genetic variants were not associated with risk of atherosclerotic coronary heart disease and glucometabolic traits in European ancestry cohort. In a South Asian cohort, identified CX3CR1 SNP associated with myocardial infarction and type II diabetes mellitus.
FKN and CX3CR1 expression was significantly increased in pancreatic ductal adenocarcinoma (PDAC) tissues, especially in the metastatic samples, and was highly-correlated with severity of PDAC. Ectopic expression of FKN promoted the proliferation and migration of PDAC, while knockdown of CX3CR1 reversed the function of FKN.
CX3CL1 (show CX3CL1 ELISA Kits) is upregulated in both human and murine tumors following VEGF (show VEGFA ELISA Kits) signaling blockade, resulting in recruitment of CX3CR1+Ly6Clo monocytes into the tumor
The fractalkine (show CX3CL1 ELISA Kits) functions on the activation of the AKT (show AKT1 ELISA Kits)/NF-kappaB (show NFKB1 ELISA Kits)/p65 (show GORASP1 ELISA Kits) signalling cascade and regulation of the antiapoptosis process in pancreatic cancer cells.
High expression of CX3CR1 correlates with significantly shorter survival, specifically in post-menopausal patients with advanced and terminal stages of the disease. Taken together, this support a key regulatory role for the fractalkine (show CX3CL1 ELISA Kits) axis in advanced and relapsed peritoneal metastasis in epithelial ovarian carcinoma.
V249I genotype of the fractalkine receptor showed a protector role in patients with type 2 diabetes. The T280M genotype is associated with increased carotid intima-media thickness in Mexican individuals with or without type 2 diabetes
CX3CR1 genetic variation sows a possible association with hypertension, diabetes mellitus and atherosclerosis comorbidities in patients treated with hemodialysis.
this study shows that the expression of CX3CR1 on tonsillar CD8-positive cells is higher in IgA nephropathy patients
Low CCRL1 expression is associated with hepatocellular carcinoma.
Recent works show that, in allergic diseases, there is an increased expression of fractalkine/CX3CL1 (show CX3CL1 ELISA Kits) and its unique receptor CX3CR1 and that this chemokine (show CCL1 ELISA Kits) does not act as chemoattractant. In allergic asthma, CX3CR1 expression regulates Th2 and Th1 (show TH1L ELISA Kits) cell survival in the inflammatory lung, while, in atopic dermatitis, it regulate Th2 and Th1 (show TH1L ELISA Kits) cell retention into the inflammatory site. [review]
These results highlight the importance of fractalkine (show CX3CL1 ELISA Kits)-CX3CR1 interaction in recruitment of macrophages into the brown adipose tissue of obese mice.
Results indicate that deletion of CX3CR1 from microglia under resting conditions modifies brain areas with elevated cellular turnover independent of CX3CL1 (show CX3CL1 ELISA Kits).
The CX3CL1 (show CX3CL1 ELISA Kits)/CX3CR1 system is essential for restricting coxsackievirus B3-induced myocarditis.
Results establish an essential role for the receptor CX3CR1 in gut (show GUSB ELISA Kits) macrophages in resolving inflammation in the intestine, where it helps protects against colitis-associated cancer by regulating HMOX-1 (show HMOX1 ELISA Kits) expression.
CX3CR1 significantly contributes to changes in microglia morphology in the proximal peri (show POSTN ELISA Kits)-infarct area following transient occlusion of the middle cerebral artery. Morphological alterations suggest a shift in microglia functionality integrated in the inflammatory response after stroke. Results show that CX3CR1 deficiency has no beneficial effect on lesion size neither it affects early functional outcome after stroke.
we demonstrated that CX3CR1(Lo)CCR2 (show CCR2 ELISA Kits)(Hi) monocytes were recruited to the GBM, where they transitioned to CX3CR1(Hi)CCR2 (show CCR2 ELISA Kits)(Lo) macrophages and CX3CR1(Hi)CCR2 (show CCR2 ELISA Kits)(-) microglia-like cells. Infiltrating macrophages/monocytes constituted approximately 85% of the total TAM (show CCNA1 ELISA Kits) population, with resident microglia accounting for the approximately 15% remaining.
CXCR4 (show CXCR4 ELISA Kits), CCR2 (show CCR2 ELISA Kits), and CX3CR1 direct dendritic cell precursors from the bone marrow to the lung differentially.
Published data show that genetic deletion of CX3CR1, a microglia-specific chemokine receptor, promotes recovery after traumatic spinal cord injury in mice, a benefit achieved in part by reducing macrophage-mediated injury at the lesion epicenter. Data in the current manuscript indicate that CX3CR1 deletion changes microglia and macrophage function, creating a tissue microenvironment that enhances endogenous repair.
this reduction in lesion formation was associated with reduced numbers of lesional SMCs but not macrophages within the transplanted Cx3cr-/- Apoe (show APOE ELISA Kits)-/- aortic segment. No differences in frequencies of proliferating and apoptotic cells could be observed. These results indicate that CX3CR1 on resident vessel wall cells plays a key role in atherosclerotic plaque formation in transplanted aortic grafts
Fractalkine is a transmembrane protein and chemokine involved in the adhesion and migration of leukocytes. The protein encoded by this gene is a receptor for fractalkine. The encoded protein also is a coreceptor for HIV-1, and some variations in this gene lead to increased susceptibility to HIV-1 infection and rapid progression to AIDS. Four transcript variants encoding two different isoforms have been found for this gene.
CX3C chemokine receptor 1
, chemokine (C-C motif) receptor-like 1
, CX3C chemokine receptor 1-like
, c-C chemokine receptor type 11-like
, chemokine (C-X3-C motif) receptor 1
, C-X-C chemokine receptor type 1
, chemokine receptor CXCR1
, C-X3-C CKR-1
, chemokine (C-X3-C) receptor 1
, fractalkine receptor
, G protein-coupled receptor 13
, G-protein coupled receptor 13
, beta chemokine receptor-like 1
, chemokine (C-C) receptor-like 1
, Fractalkine receptor
, chemokine receptor 1