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Human CX3CR1 ELISA Kit for Sandwich ELISA - ABIN367268
Zhang, Liu, Su, Shi, Chen: Serum fractalkine and interferon-gamma inducible protein-10 concentrations are early detection markers for acute renal allograft rejection. in Transplantation proceedings 2014
Mouse (Murine) CX3CR1 ELISA Kit for Sandwich ELISA - ABIN424896
Becker, Holthoff, Anthoni, Rijcken, Alexander, Gavins, Spiegel, Senninger, Vowinkel: Downregulation of CX3CR1 ameliorates experimental colitis: evidence for CX3CL1-CX3CR1-mediated immune cell recruitment. in International journal of colorectal disease 2016
Soluble FKN that was efficiently shed from the surface of LPS (show IRF6 ELISA Kits)-activated ECs in response to binding of CD16 (show CD16 ELISA Kits)(+) monocytes to ECs, diminished monocyte adhesion in down-regulating CX3CR1 expression on the surface of CD16 (show CD16 ELISA Kits)(+) monocytes resulting in decreased TNF (show TNF ELISA Kits)-secretion.
CX3CR1 genetic variants were not associated with risk of atherosclerotic coronary heart disease and glucometabolic traits in European ancestry cohort. In a South Asian cohort, identified CX3CR1 SNP associated with myocardial infarction and type II diabetes mellitus.
FKN and CX3CR1 expression was significantly increased in pancreatic ductal adenocarcinoma (PDAC) tissues, especially in the metastatic samples, and was highly-correlated with severity of PDAC. Ectopic expression of FKN promoted the proliferation and migration of PDAC, while knockdown of CX3CR1 reversed the function of FKN.
CX3CL1 (show CX3CL1 ELISA Kits) is upregulated in both human and murine tumors following VEGF (show VEGFA ELISA Kits) signaling blockade, resulting in recruitment of CX3CR1+Ly6Clo monocytes into the tumor
The fractalkine (show CX3CL1 ELISA Kits) functions on the activation of the AKT (show AKT1 ELISA Kits)/NF-kappaB (show NFKB1 ELISA Kits)/p65 (show GORASP1 ELISA Kits) signalling cascade and regulation of the antiapoptosis process in pancreatic cancer cells.
High expression of CX3CR1 correlates with significantly shorter survival, specifically in post-menopausal patients with advanced and terminal stages of the disease. Taken together, this support a key regulatory role for the fractalkine (show CX3CL1 ELISA Kits) axis in advanced and relapsed peritoneal metastasis in epithelial ovarian carcinoma.
V249I genotype of the fractalkine receptor showed a protector role in patients with type 2 diabetes. The T280M genotype is associated with increased carotid intima-media thickness in Mexican individuals with or without type 2 diabetes
CX3CR1 genetic variation sows a possible association with hypertension, diabetes mellitus and atherosclerosis comorbidities in patients treated with hemodialysis.
this study shows that the expression of CX3CR1 on tonsillar CD8-positive cells is higher in IgA nephropathy patients
Low CCRL1 expression is associated with hepatocellular carcinoma.
CX3CR1 deficiency accelerates the development of vascular pathology in diabetic retinopathy.
CX3CR1(-/-) mice did not become anhedonic in the "two hit" chronic stress paradigm, confirming resistance of these animals to chronic stress-induced mood alterations. However, there was no difference in stress hormone levels, open field performance and hypothalamic microglia distribution between the genotypes. Energy expenditure was increased in CX3CR1(-/-) mice, which may be related to their active coping behavior.
Inflammatory Osteoclasts Prime TNFalpha (show TNF ELISA Kits)-Producing CD4 (show CD4 ELISA Kits)(+) T Cells and Express CX3 CR1 (show TDGF1 ELISA Kits)
our study demonstrates that macrophages expressing a functional CX3CR1 receptor have an important and non-redundant role in controlling the abnormal intestinal inflammation that may lead to tissue damage.
These results highlight the importance of fractalkine (show CX3CL1 ELISA Kits)-CX3CR1 interaction in recruitment of macrophages into the brown adipose tissue of obese mice.
Results indicate that deletion of CX3CR1 from microglia under resting conditions modifies brain areas with elevated cellular turnover independent of CX3CL1 (show CX3CL1 ELISA Kits).
The CX3CL1 (show CX3CL1 ELISA Kits)/CX3CR1 system is essential for restricting coxsackievirus B3-induced myocarditis.
Results establish an essential role for the receptor CX3CR1 in gut (show GUSB ELISA Kits) macrophages in resolving inflammation in the intestine, where it helps protects against colitis-associated cancer by regulating HMOX-1 (show HMOX1 ELISA Kits) expression.
CX3CR1 significantly contributes to changes in microglia morphology in the proximal peri (show POSTN ELISA Kits)-infarct area following transient occlusion of the middle cerebral artery. Morphological alterations suggest a shift in microglia functionality integrated in the inflammatory response after stroke. Results show that CX3CR1 deficiency has no beneficial effect on lesion size neither it affects early functional outcome after stroke.
Fractalkine is a transmembrane protein and chemokine involved in the adhesion and migration of leukocytes. The protein encoded by this gene is a receptor for fractalkine. The encoded protein also is a coreceptor for HIV-1, and some variations in this gene lead to increased susceptibility to HIV-1 infection and rapid progression to AIDS. Four transcript variants encoding two different isoforms have been found for this gene.
, CX3C chemokine receptor 1
, G protein-coupled receptor 13
, G-protein coupled receptor 13
, beta chemokine receptor-like 1
, chemokine (C-C) receptor-like 1
, chemokine (C-X3-C) receptor 1
, fractalkine receptor
, chemokine (C-C motif) receptor-like 1
, CX3C chemokine receptor 1-like
, c-C chemokine receptor type 11-like
, C-X-C chemokine receptor type 1
, chemokine receptor CXCR1
, Fractalkine receptor
, chemokine receptor 1
, chemokine (C-X3-C motif) receptor 1