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Browse our Leukotriene C4 Synthase Proteins (LTC4S)

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Leukotriene C4 Synthase Proteins (LTC4S)
On are 5 Leukotriene C4 Synthase (LTC4S) Proteins from 4 different suppliers available. Additionally we are shipping Leukotriene C4 Synthase Antibodies (28) and Leukotriene C4 Synthase Kits (6) and many more products for this protein. A total of 43 Leukotriene C4 Synthase products are currently listed.
list all proteins Gene Name GeneID UniProt
LTC4S 4056 Q16873
LTC4S 17001 Q60860
Rat LTC4S LTC4S 114097 Q925U2

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Leukotriene C4 Synthase Proteins (LTC4S) by Origin

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More Proteins for Leukotriene C4 Synthase Interaction Partners

Human Leukotriene C4 Synthase (LTC4S) interaction partners

  1. Biochemical and structural characterization of LTC4S mutants along with crystal structures of the wild type and mutated enzymes in complex with three product analogs, provide new insights to binding of substrates and product.

  2. The results of our study failed to confirm whether the selected variants in LTC4S gene within the LT metabolism pathway contribute to platelet reactivity in a diabetic population treated with ASA (show ARSA Proteins).

  3. Elevated levels of leukotriene C4 synthase mRNA distinguish a subpopulation of eosinophilic oesophagitis patients.

  4. genetic association studies in population of Han Chinese in Eastern China: Data suggest that an SNP in LTC4S (rs730012) is associated with risk of ischemic stroke; carriers of C allele of rs730012 in LTC4S are most susceptible to ischemic stroke.

  5. meta-analysis suggested that the -444A/C polymorphism in the LTC4S gene would be a risk factor for asthma in Caucasians and aspirin-tolerant populations

  6. A significant association has been found between the -1072G/A (rs3776944) SNP in the LTC4S gene and atopic asthma in the family-based analysis.

  7. The SNPs of ALOX(5 (show ALOX5 Proteins))AP and LTC(4)S are associated with asthma.

  8. investigation of catalytic mechanism of LTC4S: Data suggest that glutathione thiolate anion formation in LTC4S is not rate-limiting for overall reaction of leukotriene C4 production. Thiolate anion is stabilized by Arg104 at all three active sites.

  9. Polymorphisms of the PTGDR (show PTGDR Proteins) and LTC4S influence responsiveness to leukotriene receptor antagonists in Korean children with asthma.

  10. The catalytic architecture of leukotriene C4 synthase with two arginine residues.

Mouse (Murine) Leukotriene C4 Synthase (LTC4S) interaction partners

  1. These results suggest that LTC(4) synthase, thought to be specific for the conjugation of GSH to LTA(4), can also recognize 5-oxoETE as an electrophilic substrate.

  2. Expression of leukotriene C4 synthase mRNA in the choroid plexus.

  3. LTC4 synthase was selectively localized in the vasopressinergic magnocellular neurons of the hypothalamic paraventricular, supraoptic and suprachiasmatic nuclei and in the retrochiasmatic area.

Cow (Bovine) Leukotriene C4 Synthase (LTC4S) interaction partners

  1. In luteal-phase endometrium, expression of 5-LO (5-lipoxygenase (show ALOX5 Proteins)) and LTB4R (leukotriene B4 receptor) is highest on Days 2-4; expression of LTCS (leukotriene-C4 synthase) and CysLTR2 (cysteinyl leukotriene receptor 2 (show CYSLTR2 Proteins)) is highest on Days 16-18. In luteal-phase endometrium, LTB4 (show PTGR1 Proteins) level is highest on Days 2-4; LTC4 level is highest on Days 16-18. Studies were conducted in Poland on Holstein Polish Black and White dairy cows.

Leukotriene C4 Synthase (LTC4S) Protein Profile

Protein Summary

The MAPEG (Membrane Associated Proteins in Eicosanoid and Glutathione metabolism) family includes a number of human proteins, several of which are involved the production of leukotrienes. This gene encodes an enzyme that catalyzes the first step in the biosynthesis of cysteinyl leukotrienes, potent biological compounds derived from arachidonic acid. Leukotrienes have been implicated as mediators of anaphylaxis and inflammatory conditions such as human bronchial asthma. This protein localizes to the nuclear envelope and adjacent endoplasmic reticulum.

Alternative names and synonyms associated with Leukotriene C4 Synthase (LTC4S)

  • leukotriene C4 synthase (LTC4S)
  • leukotriene C4 synthase, gene 1 (ltc4s.1)
  • leukotriene C4 synthase (Ltc4s)
  • ltc4s protein

Protein level used designations for LTC4S

leukotriene C4 synthase , LTC4 synthase , leukotriene-C(4) synthase

416289 Gallus gallus
705233 Macaca mulatta
739986 Pan troglodytes
770665 Gallus gallus
100379825 Xenopus (Silurana) tropicalis
4056 Homo sapiens
17001 Mus musculus
114097 Rattus norvegicus
511749 Bos taurus
100725689 Cavia porcellus
607316 Canis lupus familiaris
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