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miR (show MLXIP ELISA Kits)-26a is capable of suppressing the proliferation and migration of ESCC cells via negative regulation of metadherin
Mtdh is a potent modulator of podocyte apoptosis.
AEG-1 thus might play a role in NTIS associated with HCC (show FAM126A ELISA Kits) and other cancers.
When fed a high fat and cholesterol diet (HFD), WT mice rapidly gained weight, whereas AEG-1 KO mice did not gain weight at all.
MTDH has a critical role in male fertility and the DNA repair mechanisms required for normal spermatogenesis
Data provide evidence that MTDH has a functional role in the progression and metastatic spread of ovarian cancer.
RNA-sequencing analysis identified a unique gene signature in livers of Alb (show ALB ELISA Kits)/AEG-1/c-Myc (show MYC ELISA Kits) mice that was not observed when either AEG-1 or c-Myc (show MYC ELISA Kits) was overexpressed
Findings establish a pivotal role for MTDH in prostate cancer progression and metastasis.
IL-1beta (show IL1B ELISA Kits)- or TNF-alpha (show TNF ELISA Kits)-induced AEG-1 interaction with NF-kappaB (show NFKB1 ELISA Kits) p65 (show NFkBP65 ELISA Kits) subunit.
MTDH supports the survival of mammary epithelial cells under oncogenic/stress conditions by interacting with and stabilizing SND1 (show SND1 ELISA Kits).
Expression of AEG-1 was strongly associated with stem cell markers CD133 and SOX2 (show SOX2 ELISA Kits). AEG-1 facilitated beta-catenin (show CTNNB1 ELISA Kits) translocation into the nucleus by forming a complex with LEF1 (show LEF1 ELISA Kits) and beta-catenin (show CTNNB1 ELISA Kits), subsequently activating Wnt (show WNT2 ELISA Kits) signaling downstream genes.
High MTDH expression is associated with glioblastomas.
MTDH induces Epithelial-mesenchymal transition-like change and invasion of glioma via the regulation of miR (show MLXIP ELISA Kits)-130b-competing endogenous RNAs, providing the first direct link between MTDH and miRNAs in cancer cells.
High MTDH expression is associated with hepatocellular carcinoma.
c-Jun (show JUN ELISA Kits) and p300 (show EP300 ELISA Kits) are novel interacting partners of AEG-1 in gliomas.
Long noncoding RNA FTX regulated astrocyte-elevated gene-1 (AEG-1) expression through microRNA miR (show MLXIP ELISA Kits)-342-3p.
Study highlights the importance of interactions among lncRNA HCP5, microRNA-139, and transcription factor RUNX1 in regulating the malignant behavior of glioma cells. HCP5 down-regulated miR-139 to up-regulate RUNX1. RUNX1 promoted AEG-1 expression, which was involved in a series of oncogenic effects in glioma cells. RUNX1 also up-regulated HCP5 expression, which formed a positive feedback loop.
AEG-1 is involved in miR (show MLXIP ELISA Kits)-1297-regulated prostate cancer cell proliferation and invasion.MiR-1297 targets and inhibits AEG-1 in prostate cancer.
IL-8 (show IL8 ELISA Kits) was displayed to be capable of directly interacting with metadherin (MTDH), which in turn can up-regulate IL-8 (show IL8 ELISA Kits) expression.
human and mouse homologs are overexpressed in breast cancer tissue, bind to lung vasculature, and may play a role in promoting metastasis
, protein LYRIC
, protein LYRIC-like
, lysine-rich CEACAM1 co-isolated protein
, metastasis adhesion protein
, astrocyte elevated gene-1 protein