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Human NLRP3 Protein expressed in Wheat germ - ABIN1312675
Lu, Nakamura, Inouye, Li, Tang, Lundbäck, Valdes-Ferrer, Olofsson, Kalb, Roth, Zou, Erlandsson-Harris, Yang, Ting, Wang, Andersson, Antoine, Chavan, Hotamisligil, Tracey: Novel role of PKR in inflammasome activation and HMGB1 release. in Nature 2012
Show all 5 Pubmed References
The present study confirms the weak clinical and functional effect of the p.Q703K variant of NLRP3.
NLRP3 inflammasome is activated in Crohn's Disease patients and in Ulcerative Colitis patients with long-standing disease.
By generating a mouse line in which the NLRP3 locus is humanized by syntenic replacement, we show the functioning of the human NLRP3 proteins in vivo, demonstrating the ability of the human inflammasome to orchestrate immune reactions in response to innate stimuli
Ethanol exposure for 24 hours or 7 days does not affect the proliferation of induced pluripotent stem cells and neural progenitor cells, but primes an innate immune-like response by activating the NLR family pyrin domain containing 3 (NLRP3) inflammasome pathway.
Patients with low-penetrance NLRP3 variants display a distinct clinical phenotype and an intermediate biologic phenotype, including IL-1beta (show IL1B Proteins) and non-IL-1beta (show IL1B Proteins)-mediated inflammatory pathway activation.
the association of TXNIP (thioredoxin-interacting protein (show TXNIP Proteins)) with NLRP3 induced by ROS (show ROS1 Proteins) promoted NLRP3 inflammasome activation in senescent HUVEC endothelial cells
these findings are the first to identify NLRP3 as an inflammasome sensor for Toxoplasma gondii in primary human peripheral blood cells and to define an upstream regulator of its activation through the release of intracellular potassium
Stress-Induced NLRP3 inflammasome complex emerges as an important factor in the pathogenesis and progression of human diseases. [review]
that NLRP3 may have specific function in the spiral ganglion neurons and can be associated with both syndromic and nonsyndromic sensorineural deafness
results firstly revealed that irisin (show FNDC5 Proteins) mitigated oxygen-glucose deprivation-induced neuronal injury in part via inhibiting ROS (show ROS1 Proteins)-NLRP3 inflammatory signaling pathway, suggesting a likely mechanism for irisin (show FNDC5 Proteins)-induced therapeutic effect in ischemic stroke.
Results indicate CLICs (CLIC1 (show CLIC1 Proteins), CLIC4 (show CLIC4 Proteins) and CLIC5 (show CLIC5 Proteins))-dependent chloride efflux as an essential and proximal upstream event for NLRP3 activation.
Results indicate that a selective and direct small-molecule inhibitor for NLRP3 inflammasome and that NLRP3 can be targeted in vivo to combat NLRP3-driven diseases.
Study demonstrated that the NLRP3 inflammasome was involved in the chronic unpredictable mild stress-induced depression-like behaviors via regulating IL-1beta (show IL1B Proteins) protein expression in serum and hippocampus, MAPK (show MAPK1 Proteins) pathway and NF-kappaB (show NFKB1 Proteins) protein complex activation.
The results of this study suggests that NLRP3 inflammasome activation contribute to inflammation in hippocampus upon to deprivation of ovary.
the NLRP3-activating agonists, ATP and nigericin, prevent STING pathway activation in association with mitochondrial fragmentation; however, the suppression of the STING pathway and mitochondria fission were not dependent on NLRP3 or potassium efflux.
Data suggest that activity of Nlrp3 inflammasome can be modulated by dietary factors; here, omega-3 fatty acids from fish oil dietary supplements down-regulate Nlrp3 inflammasome activity and gene expression of Nlrp3 in adipocytes and macrophages of obese mice.
GAS6 (show GAS6 Proteins)-AXL (show AXL Proteins) signaling-mediated autophagy induction in murine macrophages ameliorates hepatic inflammatory responses by inhibiting NLRP3 inflammasome activation.
NLRP3-/- mice exhibited resistance to indomethacin-induced small intestinal damage
MiR (show MLXIP Proteins)-133b suppresses Nlrp3 inflammasome activation in nasal mucosa of Allergic Rhinitis mice.
This gene encodes a pyrin-like protein containing a pyrin domain, a nucleotide-binding site (NBS) domain, and a leucine-rich repeat (LRR) motif. This protein interacts with the apoptosis-associated speck-like protein PYCARD/ASC, which contains a caspase recruitment domain, and is a member of the NALP3 inflammasome complex. This complex functions as an upstream activator of NF-kappaB signaling, and it plays a role in the regulation of inflammation, the immune response, and apoptosis. Mutations in this gene are associated with familial cold autoinflammatory syndrome (FCAS), Muckle-Wells syndrome (MWS), chronic infantile neurological cutaneous and articular (CINCA) syndrome, and neonatal-onset multisystem inflammatory disease (NOMID). Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene. Alternative 5' UTR structures are suggested by available data\; however, insufficient evidence is available to determine if all of the represented 5' UTR splice patterns are biologically valid.
NACHT, LRR and PYD domains-containing protein 3
, cold autoinflammatory syndrome 1
, NLR family, pyrin domain containing 3
, NACHT, LRR and PYD domains-containing protein 3-like
, NACHT domain-, leucine-rich repeat-, and PYD-containing protein 3
, NACHT, LRR and PYD containing protein 3
, PYRIN-containing APAF1-like protein 1
, caterpiller protein 1.1
, cold autoinflammatory syndrome 1 protein
, nucleotide-binding oligomerization domain, leucine rich repeat and pyrin domain containing 3
, NACHT/LRR/pyrin domain-containing protein 3
, cold autoinflammatory syndrome 1 homolog
, cold autoinflammatory syndrome 1 protein homolog
, mast cell maturation inducible protein 1
, mast cell maturation-associated-inducible protein 1
, NLR family pyrin domain containing 3