Browse our NLRP3 Proteins (NLRP3)

Full name:
NLR Family, Pyrin Domain Containing 3 Proteins (NLRP3)
On www.antibodies-online.com are 4 NLR Family, Pyrin Domain Containing 3 (NLRP3) Proteins from 2 different suppliers available. Additionally we are shipping NLRP3 Antibodies (222) and NLRP3 Kits (11) and many more products for this protein. A total of 251 NLRP3 products are currently listed.
Synonyms:
AGTAVPRL, AII, AII/AVP, AVP, C1orf7, Cias1, CLR1.1, FCAS, FCU, Mmig1, MWS, NALP3, Pypaf1
list all proteins Gene Name GeneID UniProt
NLRP3 114548 Q96P20
NLRP3 216799 Q8R4B8
Rat NLRP3 NLRP3 287362  

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NLRP3 Proteins (NLRP3) by Origin

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Top referenced NLRP3 Proteins

  1. Human NLRP3 Protein expressed in Wheat germ - ABIN1312675 : Lu, Nakamura, Inouye, Li, Tang, Lundbäck, Valdes-Ferrer, Olofsson, Kalb, Roth, Zou, Erlandsson-Harris, Yang, Ting, Wang, Andersson, Antoine, Chavan, Hotamisligil, Tracey: Novel role of PKR in inflammasome activation and HMGB1 release. in Nature 2012 (PubMed)
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More Proteins for NLRP3 Interaction Partners

Human NLR Family, Pyrin Domain Containing 3 (NLRP3) interaction partners

  1. level of TGF-beta1 (show TGFB1 Proteins) was reduced after NLRP3 silencing. These results indicated that the NLRP3 inflammasome was activated in alveolar epithelial cells

  2. SNPs in NLRP3 and CTSB (show CTSB Proteins), associated with an increased NLRP3-inflammasome activation, are protective against the development of active pulmonary tuberculosis.

  3. defective ribosomal products in blebs induced IL-1beta (show IL1B Proteins) release from peripheral blood mononuclear cells or THP-1 cells without lipopolysaccharide priming, but required the core machinery of NLRP3 inflammasomes.

  4. besides its role in the inhibition of the NF-kappaB (show NFKB1 Proteins) pathway, NLRC3 interferes with the assembly and activity of the NALP3 inflammasome complex by competing with ASC (show PYCARD Proteins) for pro-caspase-1 (show CASP1 Proteins) binding

  5. uropathogenic E. coli use the multifunctional virulence factor TcpC to induce NLRP3 inflammasome expression, and attenuate innate immune responses in the urinary tract

  6. miR (show MLXIP Proteins)-223 limits intestinal inflammation by constraining the nlrp3 inflammasome.

  7. These data suggest that targeting NLRP3 holds the promise for the immunotherapy of pancreatic ductal adenocarcinoma.

  8. EAE induced by weak activation of innate immunity requires the NLRP3 inflammasome and is sensitive to interferon-beta (show IFNB1 Proteins) treatment

  9. this is the first report describing the existence and function of the nucleotide-binding oligomerization domain-like receptor protein 3 (show HSPB3 Proteins) inflammasome in human dendritic cells.

  10. PTPN22 (show PTPN22 Proteins) deficiency resulted in pronounced colitis, increased NLRP3 phosphorylation, but reduced levels of mature IL-1beta (show IL1B Proteins).

Mouse (Murine) NLR Family, Pyrin Domain Containing 3 (NLRP3) interaction partners

  1. The results indicate that the NLRP3 inflammasome links the innate recognition of S. schenckii to the adaptive immune response, so contributing to protection against this infection.

  2. TNF (show TNF Proteins)-driven NLRP3 expression constitutes an important checkpoint that regulates inflammasome activation, presumably by additional signals such as aging-associated damage-associated molecular pattern (DAMP (show AMPH Proteins)).

  3. proposed that TLR9 (show TLR9 Proteins) regulates the NF-kappaB (show NFKB1 Proteins)-NLRP3-IL-1beta (show IL1B Proteins) pathway negatively in Salmonella-induced NKG2D (show KLRK1 Proteins)-mediated intestinal inflammation and plays a critical role in defense against S. typhimurium infection and in the protection of intestinal integrity.

  4. The results suggest that mitochondrial function is required somewhat specifically for ATP-induced NLRP3 inflammasome activation.

  5. uropathogenic E. coli use the multifunctional virulence factor TcpC to induce NLRP3 inflammasome expression, and attenuate innate immune responses in the urinary tract

  6. NLRP3(-/-) mice had reduced defects in echo/Doppler parameters in heart after cecal ligation and puncture

  7. this study shows that plant lectins can act as an exogenous "danger signal" that can activate the NLRP3 inflammasome and suggest that dietary lectins might promote inflammatory diseases via the NLRP3 inflammasome

  8. miR (show MLXIP Proteins)-223 limits intestinal inflammation by constraining the nlrp3 inflammasome.

  9. NLRP3 is a novel target of the YopM protein.

  10. These results propose that the balance between kinases and phosphatases acting on the NLRP3 pyrin (show MEFV Proteins) domain is critical for NLRP3 activation.

NLRP3 Protein Profile

Protein Summary

This gene encodes a pyrin-like protein containing a pyrin domain, a nucleotide-binding site (NBS) domain, and a leucine-rich repeat (LRR) motif. This protein interacts with the apoptosis-associated speck-like protein PYCARD/ASC, which contains a caspase recruitment domain, and is a member of the NALP3 inflammasome complex. This complex functions as an upstream activator of NF-kappaB signaling, and it plays a role in the regulation of inflammation, the immune response, and apoptosis. Mutations in this gene are associated with familial cold autoinflammatory syndrome (FCAS), Muckle-Wells syndrome (MWS), chronic infantile neurological cutaneous and articular (CINCA) syndrome, and neonatal-onset multisystem inflammatory disease (NOMID). Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene. Alternative 5' UTR structures are suggested by available data\; however, insufficient evidence is available to determine if all of the represented 5' UTR splice patterns are biologically valid.

Alternative names and synonyms associated with NLRP3

  • NLR family, pyrin domain containing 3 (NLRP3)
  • NLR family, pyrin domain containing 3 (LOC100351623)
  • NLR family, pyrin domain containing 3 (nlrp3)
  • NLR family, pyrin domain containing 3 (Nlrp3)
  • AGTAVPRL protein
  • AII protein
  • AII/AVP protein
  • AVP protein
  • C1orf7 protein
  • Cias1 protein
  • CLR1.1 protein
  • FCAS protein
  • FCU protein
  • Mmig1 protein
  • MWS protein
  • NALP3 protein
  • Pypaf1 protein

Protein level used designations for NLRP3

NACHT, LRR and PYD domains-containing protein 3 , cold autoinflammatory syndrome 1 , cryopyrin , NLR family, pyrin domain containing 3 , NACHT, LRR and PYD domains-containing protein 3-like , NACHT domain-, leucine-rich repeat-, and PYD-containing protein 3 , NACHT, LRR and PYD containing protein 3 , PYRIN-containing APAF1-like protein 1 , caterpiller protein 1.1 , cold autoinflammatory syndrome 1 protein , nucleotide-binding oligomerization domain, leucine rich repeat and pyrin domain containing 3 , NACHT/LRR/pyrin domain-containing protein 3 , cold autoinflammatory syndrome 1 homolog , cold autoinflammatory syndrome 1 protein homolog , mast cell maturation inducible protein 1 , mast cell maturation-associated-inducible protein 1 , NLR family pyrin domain containing 3

GENE ID SPECIES
423021 Gallus gallus
469743 Pan troglodytes
490576 Canis lupus familiaris
100351623 Oryctolagus cuniculus
100381165 Xenopus laevis
100392399 Callithrix jacchus
114548 Homo sapiens
216799 Mus musculus
538639 Bos taurus
287362 Rattus norvegicus
701278 Macaca mulatta
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