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Browse our NLRP3 Proteins (NLRP3)

Full name:
NLR Family, Pyrin Domain Containing 3 Proteins (NLRP3)
On are 4 NLR Family, Pyrin Domain Containing 3 (NLRP3) Proteins from 2 different suppliers available. Additionally we are shipping NLRP3 Antibodies (205) and NLRP3 Kits (8) and many more products for this protein. A total of 230 NLRP3 products are currently listed.
AGTAVPRL, AII, AII/AVP, AVP, C1orf7, Cias1, CLR1.1, FCAS, FCU, Mmig1, MWS, NALP3, Pypaf1
list all proteins Gene Name GeneID UniProt
NLRP3 114548 Q96P20
NLRP3 216799 Q8R4B8
Rat NLRP3 NLRP3 287362  

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NLRP3 Proteins (NLRP3) by Origin

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Top referenced NLRP3 Proteins

  1. Human NLRP3 Protein expressed in Wheat germ - ABIN1312675 : Lu, Nakamura, Inouye, Li, Tang, Lundbäck, Valdes-Ferrer, Olofsson, Kalb, Roth, Zou, Erlandsson-Harris, Yang, Ting, Wang, Andersson, Antoine, Chavan, Hotamisligil, Tracey: Novel role of PKR in inflammasome activation and HMGB1 release. in Nature 2012 (PubMed)
    Show all 4 references for ABIN1312675

More Proteins for NLRP3 Interaction Partners

Human NLR Family, Pyrin Domain Containing 3 (NLRP3) interaction partners

  1. One of the key results of this study is that the induction of NLRP3 expression by Lipopolysaccharide is inhibited in the presence of IL-4 (show IL4 Proteins)+IL-13 (show IL13 Proteins) (M2 phenotype) at both mRNA and protein level in monocytes and macrophages.

  2. The objective of this review is to integrate the findings linking mitochondrial integrity to the activation of the NLRP3 inflammasome and to evaluate how caloric restriction or caloric restriction mimetic compounds may play a role in attenuating the NLRP3 inflammasome and sterile inflammation. [review]

  3. There is a positive correlation of NLRP3 level with severity of coronary atherosclerosis. NLRP3 showed good predictive value for major adverse cardiac events.

  4. NLRP3 inflammasome signaling pathway played a pro-inflammatory role in the pathogenesis of human chronic rhinosinusitis with nasal polyps , especially in Eosinophilic CRSwNP

  5. Lipopolysaccharide activates the reactive oxygen spieces -dependent NLRP3 inflammasome.

  6. NLRP3 inflammasome activation can lead to NAFLD development and progression, including hepatic steatosis, inflammation, liver injury, and fibrogenesis. NLRP3 inflammasome may serve as a novel therapeutic target for the treatment of Nonalcoholic fatty liver disease and Nonalcoholic steatohepatitis.

  7. The mutation c.92A>T in exon 1 of the NLRP3 gene is a novel mutation associated with Muckle-Wells Syndrome.

  8. Xanthine oxidase induces foam cell formation in large part through activation of LOX-1 - NLRP3 pathway in both vascular smooth muscle cells and THP-1 cells.

  9. genetic polymorphisms in NLRP3 may influence ischemic stroke risk in Chinese population

  10. NLRP3 inflammasome is implicated in the pathogenesis of dermatomyositis and polymyositis.

Mouse (Murine) NLR Family, Pyrin Domain Containing 3 (NLRP3) interaction partners

  1. NLRP3 inflammasome and local IL-1beta((+))F4/80((+))Ly6C((+)) inflammatory macrophages contribute to pathogenesis of VCP-associated myopathy

  2. this study shows that genipin protects against acute lung injury through inhibiting NLRP3 signaling pathway

  3. this study shows that neuroprotective effect of sinomenine against ischemic stroke is mediated via suppression of NLRP3 inflammasome

  4. this study shows that the protective effect of rhapontin is from blocking the NLRP3 priming cascade reaction and is dependent on SIRT1 (show SIRT1 Proteins) activation

  5. this study shows that LPS (show TLR4 Proteins)-induced mastitis can be abated by mangiferin through inhibiting NLRP3 signaling pathway

  6. telmisartan can reduce traumatic cerebral edema by inhibiting the NLRP3 inflammasome-regulated IL-1beta (show IL1B Proteins) and IL-18 (show IL18 Proteins) accumulation.

  7. this study shows that biochanin A protects acute liver injury by inhibiting NLRP3 inflammasome activation

  8. Study suggests that NLRP3 has a limited role in the development of burn-induced pain.

  9. Data show that inhibiting caspase-1 (show CASP1 Proteins) activity in the NLR (show CXCR5 Proteins) family, pyrin domain-containing 3 protein (NLRP3) inflammasome decreased gastric cell apoptosis.

  10. Authors conclude that Aldo induces renal tubular cell injury via MR dependent, mitochondrial ROS (show ROS1 Proteins)-mediated NLRP3 inflammasome activation.

NLRP3 Protein Profile

Protein Summary

This gene encodes a pyrin-like protein containing a pyrin domain, a nucleotide-binding site (NBS) domain, and a leucine-rich repeat (LRR) motif. This protein interacts with the apoptosis-associated speck-like protein PYCARD/ASC, which contains a caspase recruitment domain, and is a member of the NALP3 inflammasome complex. This complex functions as an upstream activator of NF-kappaB signaling, and it plays a role in the regulation of inflammation, the immune response, and apoptosis. Mutations in this gene are associated with familial cold autoinflammatory syndrome (FCAS), Muckle-Wells syndrome (MWS), chronic infantile neurological cutaneous and articular (CINCA) syndrome, and neonatal-onset multisystem inflammatory disease (NOMID). Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene. Alternative 5' UTR structures are suggested by available data\; however, insufficient evidence is available to determine if all of the represented 5' UTR splice patterns are biologically valid.

Alternative names and synonyms associated with NLRP3

  • NLR family, pyrin domain containing 3 (NLRP3)
  • NLR family, pyrin domain containing 3 (LOC100351623)
  • NLR family, pyrin domain containing 3 (nlrp3)
  • NLR family, pyrin domain containing 3 (Nlrp3)
  • AGTAVPRL protein
  • AII protein
  • AII/AVP protein
  • AVP protein
  • C1orf7 protein
  • Cias1 protein
  • CLR1.1 protein
  • FCAS protein
  • FCU protein
  • Mmig1 protein
  • MWS protein
  • NALP3 protein
  • Pypaf1 protein

Protein level used designations for NLRP3

NACHT, LRR and PYD domains-containing protein 3 , cold autoinflammatory syndrome 1 , cryopyrin , NLR family, pyrin domain containing 3 , NACHT, LRR and PYD domains-containing protein 3-like , NACHT domain-, leucine-rich repeat-, and PYD-containing protein 3 , NACHT, LRR and PYD containing protein 3 , PYRIN-containing APAF1-like protein 1 , caterpiller protein 1.1 , cold autoinflammatory syndrome 1 protein , nucleotide-binding oligomerization domain, leucine rich repeat and pyrin domain containing 3 , NACHT/LRR/pyrin domain-containing protein 3 , cold autoinflammatory syndrome 1 homolog , cold autoinflammatory syndrome 1 protein homolog , mast cell maturation inducible protein 1 , mast cell maturation-associated-inducible protein 1 , NLR family pyrin domain containing 3

423021 Gallus gallus
469743 Pan troglodytes
490576 Canis lupus familiaris
100351623 Oryctolagus cuniculus
100381165 Xenopus laevis
100392399 Callithrix jacchus
114548 Homo sapiens
216799 Mus musculus
538639 Bos taurus
287362 Rattus norvegicus
701278 Macaca mulatta
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