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PLSCR2 is expressed predominantly in the cell nucleus
hPLSCR1 and PRD-hPLSCR2 showed Ca(2 (show CA2 Proteins)+)-dependent aggregation and scrambling activity
Results show that binding affinities of the peptides are in the order hPLSCR1>hPLSCR3>hPLSCR2>hPLSCR4 for Ca2 (show CA2 Proteins)+ and in the order hPLSCR1>hPLSCR2>hPLSCR3>hPLSCR4 for Mg2 (show MUC7 Proteins)+.
This gene encodes a member of the phospholipid scramblase family. Phospholipid scramblases are membrane proteins that mediate calcium-dependent, non-specific movement of plasma membrane phospholipids and phosphatidylserine exposure. The encoded protein contains a low affinity calcium binding motif and may play a role in blood coagulation and apoptosis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
phospholipid scramblase 2
, PL scramblase 2
, ca(2+)-dependent phospholipid scramblase 2