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PML Proteins

(Promyelocytic Leukemia (PML))
The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This phosphoprotein localizes to nuclear bodies where it functions as a transcription factor and tumor suppressor. Its expression is cell-cycle related and it regulates the p53 response to oncogenic signals. The gene is often involved in the translocation with the retinoic acid receptor alpha gene associated with acute promyelocytic leukemia (APL). Extensive alternative splicing of this gene results in several variations of the protein's central and C-terminal regions\; all variants encode the same N-terminus. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008].
PML Protein (AA 1-885) (His tag) PML Protein (AA 1-885) (His tag) PML Protein (AA 1-885) (His tag) (ABIN3135325)

Crystallography grade PML Origin: Mouse Host: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. WB, SDS, ELISA, Crys

PML Protein (AA 1-882) (His tag) PML Protein (AA 1-882) (His tag) PML Protein (AA 1-882) (His tag) (ABIN3094674)

Crystallography grade PML Origin: Human Host: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. WB, SDS, ELISA, Crys

PML Protein (Transcript Variant 9) (Myc-DYKDDDDK Tag) PML Protein (Transcript Variant 9) (Myc-DYKDDDDK Tag) PML Protein (Transcript Variant 9) (Myc-DYKDDDDK Tag) (ABIN2729208)

PML Origin: Human Host: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD

PML Proteins by Grade

Find PML Proteins with a specific Grade. The Grade listed below are among those available. Click on a link to go to the corresponding products.

PML Proteins by Origin

Find PML Proteins for a variety of species such as anti-Human PML, anti-Mouse PML. The species listed below are among those available. Click on a link to go to the corresponding products.

PML Proteins by Source

Here you will find PML Proteins proteins organized by several key sources. By clicking on a link, you can access the products. For additional sources, please use our search function.

PML Proteins by Protein Type

Here you can find PML Proteins proteins categorized by available protein types. Additional protein types can be located using our search function.

PML Proteins by Application

Find PML Proteins validated for a specific application such as WB, AbP, ELISA, SDS. Some of the available applications are listed below. Click on a link to go to the corresponding products.

Popular PML Proteins

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Mouse
Source Insect Cells
Validations
  • (1)
Cat. No. ABIN3135325
Quantity 1 mg
Datasheet Datasheet
Reactivity Human
Source Insect Cells
Validations
  • (1)
Cat. No. ABIN3094674
Quantity 1 mg
Datasheet Datasheet
Reactivity Human
Source HEK-293 Cells
Validations
  • (1)
  • (1)
Cat. No. ABIN2729208
Quantity 20 μg
Datasheet Datasheet
Reactivity Human
Source Escherichia coli (E. coli)
Validations
Cat. No. ABIN7396061
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1315516
Quantity 10 μg
Datasheet Datasheet
Reactivity Human
Source HEK-293 Cells
Validations
  • (1)
Cat. No. ABIN2729210
Quantity 20 μg
Datasheet Datasheet
Reactivity Human
Source HEK-293 Cells
Validations
  • (1)
Cat. No. ABIN2729209
Quantity 20 μg
Datasheet Datasheet

Latest Publications for our PML Proteins

Missiroli, Perrone, Gafà, Nicoli, Bonora, Morciano, Boncompagni, Marchi, Lebiedzinska-Arciszewska, Vezzani, Lanza, Kricek, Borghi, Fiorica, Ito, Wieckowski, Di Virgilio, Abelli, Pinton, Giorgi: "PML at mitochondria-associated membranes governs a trimeric complex with NLRP3 and P2X7R that modulates the tumor immune microenvironment." in: Cell death and differentiation, pp. 1-13, (2022) (PubMed).

Aliases for PML Proteins

promyelocytic leukemia (PML) Proteins
promyelocytic leukemia (Pml) Proteins
1200009E24Rik Proteins
AI661194 Proteins
MYL Proteins
PML Proteins
PP8675 Proteins
RGD1562602 Proteins
RNF71 Proteins
TRIM19 Proteins
Trim19 Proteins
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