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SMS regulates the expression and function of drug transporters P-gp and MRP2.
HepG2 cells stably transfected with SMS1 (HepG2-SMS1) exhibit elevated enzyme activity in vitro and increased sphingomyelin content (mainly C22:0- and C24:0-sphingomyelin) but lower hexosylceramide (Hex (show HHEX ELISA Kits)-Cer (show CBLN1 ELISA Kits)) levels.
Sphingomyelin synthase 1 positively regulates KCNQ1 (show KCNQ1 ELISA Kits)/KCNE1 (show KCNE1 ELISA Kits) channel density in a protein kinase D (show PRKD1 ELISA Kits)-dependent manner.
A study of the expression of the full-length SMS1 protein and the sum of the alternative transcripts encoding this protein in human tissues.
The structural organization of 5'-UTR (show UTS2R ELISA Kits) variants of SGMS1 transcripts, directed by alternative promoters, is substantially different; this can provide regulation of the gene functioning on post-transcriptional level.
We found upregulation of specific sphingolipid enzymes, namely sphingomyelin synthase 1 (SMS1), sphingomyelinase 3 (SMPD3), and glucosylceramide synthase (GCS (show UGCG ELISA Kits)) in the endometrium of endometriotic women.
SGMS activity impacts on amyloid precursor protein (show APP ELISA Kits) processing to produce amyloid-beta (Abeta (show APP ELISA Kits)) and it could be a contributing factor in Abeta (show APP ELISA Kits) pathology associated with Alzheimer's disease.
The amount of SMS1 transcripts varies considerably between different human tissues.
Findings indicate that Sms1 is a downstream target of Bcr-abl (show ABL1 ELISA Kits), involved in sustaining cell proliferation of Bcr-abl (show ABL1 ELISA Kits)-positive cells.
SMS1 and SMS2 (show SGMS2 ELISA Kits) are capable of regulating TGN (show TG ELISA Kits)-mediated protein trafficking and secretion
SMS1 has a wider than anticipated role in testis polyunsaturated fatty acid homeostasis and for male fertility
Sphingomyelin synthase 1 regulates Neuro-2a cell proliferation and cell cycle progression through modulation of p27 (show CDKN1B ELISA Kits) expression and Akt (show AKT1 ELISA Kits) signaling
study reveals that all mouse SMS family members (SMSr, SMS1, and SMS2) have CPE synthase activity
that SMS1 is crucial to control oxidative stress in order to maintain white adipose tissue function.
Defects in the stria vascularis with reductions in endocochlear potentials together with hair cell dysfunction may account, at least partially, for hearing impairments in SMS1-/- mice.
The deficiency of membrane sphingomyelin caused the CD4 (show CD4 ELISA Kits) T-cell dysfunction through impaired lipid raft function contributing to protection of ConA-induced liver injury, and suggesting that the membrane sphingomyelin is critical for full T-cell activation.
Sms1 deficiency decreases sphingomyelin, but dramatically increases the levels of glycosphingolipids. Atherosclerosis in Sms1(-/-)-->Ldlr (show LDLR ELISA Kits)(-/-) mice is significantly decreased.
SMS1 and SMS2 (show SGMS2 ELISA Kits) play distinct roles in regulating local sphingomyelin clustering.
SMS1-mediated SM synthesis directs Tf-TfR to undergo clathrin-dependent endocytosis and recycling, promoting the proliferation of lymphoma cells.
SMS1 is important for controlling ROS (show ROS1 ELISA Kits) generation, and SMS1 is required for normal mitochondrial function and insulin (show INS ELISA Kits) secretion in pancreatic beta-cells
The protein encoded by this gene is predicted to be a five-pass transmembrane protein. This gene may be predominately expressed in brain.
phosphatidylcholine:ceramide cholinephosphotransferase 1
, sphingomyelin synthase 1
, phosphatidylcholine:ceramide cholinephosphotransferase 1-like
, medulla oblongata-derived protein
, protein Mob
, transmembrane protein 23