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Human TNFSF4 Protein expressed in HEK-293 Cells - ABIN1344408
Mestas, Crampton, Hori, Hughes: Endothelial cell co-stimulation through OX40 augments and prolongs T cell cytokine synthesis by stabilization of cytokine mRNA. in International immunology 2005
House dust mite sublingual immunotherapy downregulated Th2-type immune responses mediated by the TSLP (show TSLP Proteins)-OX40L signaling pathway in patients with persistent moderate to severe allergic rhinitis.
OX40 (show TNFRSF4 Proteins) and OX40L formed a functional complex, which may facilitate signal transduction from OX40L to OX40 (show TNFRSF4 Proteins) and contribute to the pathogenesis of Grave's disease.
The polymorphisms of the TNFSF4 gene may contribute to the susceptibility to pathogenesis of early-Onset Autoimmune Thyroid Diseases and Hypothyroidism of Hashimoto's Thyroiditis.
the SNPs in TNFSF4 and FAM167A-BLK may be involved in asthma and allergic rhinitis gene risk in the Han Chinese cohort.
Given the discovery cohort, functional data, and importance of TNFSF4 in infection clearance, TNFSF4C may associate with outcomes and warrants future studies.
Review/Meta-analysis: TNFSF4 (rs3850641) polymorphisms is not associated with coronary heart disease risk.
Study showed that the A allele of the rs7518045 and haplotype rs3861950C-rs17346501C-rs7518045A-rs1234313G in the TNFSF4 gene were associated with decreased risk for myocardial infarction in a Chinese Han population.
Data indicate that soluble OX40 (show TNFRSF4 Proteins) and sOX40L plasma levels are increased in early rheumatoid arthritis patients.
Report role of TNFSF4 genetic variants in confering risk of systemic lupus erythematosus in Chinese population.
There were no significant associations between rs1234313, rs1234314 and rs17568 and atherosclerotic cerebral infarction risk in a Han Chinese population.
These data support the hypothesis that the Ox40 (show TNFRSF4 Proteins)/Ox40L pathway drives cellular and humoral autoimmune responses during lupus nephritis in NZB/W F1 mice and emphasize the potential clinical value of targeting this pathway in human lupus.
The OX40L expression is induced on the bronchiolar progenitors for the antiviral immunity during the infectious process. However, these defense-like host responses lead to more extensive infection with the influenza virus owing to the induced OX40L with alpha-2,6 sialic acid modification, which augments the interaction with the viral hemagglutinin (show HA Proteins).
bone marrow-derived mast cell (BMMC)-exosomes facilitated the differentiation of naive CD4 (show CD4 Proteins)+ T cells to Th2 cells by ligation of OX40L and OX40 (show TNFRSF4 Proteins) between BMMC-exosomes and CD4 (show CD4 Proteins)+ T cells and represents a novel mechanism of cell-to-cell communication
Rhinovirus infection interferes with induction of tolerance to aeroantigens through OX40 ligand, thymic stromal lymphopoietin (show TSLP Proteins), and IL-33 (show IL33 Proteins)
Anti-OX40L mAb could prolong secondary heart allograft survival based on CD40 (show CD40 Proteins)/CD40L (show CD40LG Proteins) and LFA-1 (show ITGAL Proteins)/ICAM-1 (show ICAM1 Proteins) blockade.
intestinal Th2 priming is initiated by an autocrine/paracrine acting CD4 (show CD4 Proteins)(+) Th cell-intrinsic IL-4 (show IL4 Proteins) program that is controlled by DC OX40L, and not by NKT (show CTSL1 Proteins), gammadelta T, or ILC (show CCL27 Proteins) cells.
a critical role of OX40L presented by the activated basophils to initiate Th2 responses in an allergic asthma model, implicating OX40 (show TNFRSF4 Proteins)-OX40L signaling as a potential therapeutic target in the treatment of allergic airway inflammation.
The majority of transferred CD40L (show CD40LG Proteins)(-/-) T cells in Rag-1 (show RAG1 Proteins)(-/-) B6 mice were differentiated to CD44 (show CD44 Proteins)(high).
OX40 (show TNFRSF4 Proteins)-OX40L interaction regulates the expression of NFATc1 (show NFATC1 Proteins), which may play a critical role in atherosclerotic plaque formation, and may therefore have implications with pathophysiology of atherosclerosis.
The need for additional immune suppression in the intestine reflects commensal microbe-driven T-cell activation through the accessory costimulation molecules ICOSL (show ICOSLG Proteins) and OX40L in B7 deprived mice.
The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for receptor TNFRSF4/OX4. It is found to be involved in T cell antigen-presenting cell (APC) interactions. In surface Ig- and CD40-stimulated B cells, this cytokine along with CD70 has been shown to provide CD28-independent costimulatory signals to T cells. This protein and its receptor are reported to directly mediate adhesion of activated T cells to vascular endothelial cells.
tumor necrosis factor (ligand) superfamily, member 4 (tax-transcriptionally activated glycoprotein 1, 34kDa)
, tumor necrosis factor (ligand) superfamily, member 4
, tumor necrosis factor ligand superfamily member 4
, OX40L protein
, CD134 ligand
, OX40 antigen ligand
, TAX transcriptionally-activated glycoprotein 1
, glycoprotein Gp34
, tax-transcriptionally activated glycoprotein 1 (34kD)
, OX40 ligand
, atherosclerosis 1
, tax-transcriptionally activated glycoprotein 1 ligand