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BCL6 forms a complex with BCL6 corepressor (BCoR (show BCOR ELISA Kits)) on the promoters of selected Notch (show NOTCH1 ELISA Kits) target genes such as enhancer of split related 1.
These data describe a novel regulatory mechanism through which STAT3 (show STAT3 ELISA Kits) and the Ikaros (show IKZF1 ELISA Kits) zinc finger transcription factors Aiolos (show IKZF3 ELISA Kits) and Ikaros (show IKZF1 ELISA Kits) cooperate to regulate Bcl-6 expression.
Our data reveal a regulatory role of BCL6 in inhibiting antiviral resistance factors in follicular Th cells
data provide a novel mechanism for positive control of gene expression by Bcl6, and illuminate how Bcl6 and Blimp1 (show PRDM1 ELISA Kits) control follicular helper T cell differentiation
both mouse and human B cells, IFN-gamma (show IFNG ELISA Kits) synergized with B cell receptor, toll (show TLR4 ELISA Kits)-like receptor, and/or CD40 (show CD40 ELISA Kits) activation signals to promote cell-intrinsic expression of the GC master transcription factor, B cell lymphoma 6 protein.
observations reveal that KLF6 (show KLF6 ELISA Kits) repress BCL6 to enhance macrophage inflammatory gene expression and function.
synergistic activity of Card11 (show CARD11 ELISA Kits) mutant and Bcl6 in the development of diffuse large B-cell lymphoma in a mouse model
Bcl6, by interacting with the co-factors NcoR2 and HDAC3 (show HDAC3 ELISA Kits), plays a pivotal role in controlling IRF7 (show IRF7 ELISA Kits) induction and antiviral signaling priming.
Bcl6 promoted T follicular helper cell differentiation through antagonizing IL-7R / STAT5a (show STAT5A ELISA Kits) axis.
Bob1 (show POU2AF1 ELISA Kits) directly binds to and transactivate the Bcl6 promoter during the development of follicular T helper cells .
upon binding to a composite NFAT (show NFATC1 ELISA Kits)/BCL6 regulatory element within the Ccl2 (show CCL2 ELISA Kits) promoter, NFATc1 (show NFATC1 ELISA Kits)/beta proteins release the BCL6-dependent repression of Ccl2 (show CCL2 ELISA Kits) gene in macrophages.
Data suggest that B-cell CLL/lymphoma 6 is a promising candidate as a single diagnostic biomarker for detection of endometriosis in women with otherwise unexplained infertility and may be associated with endometrial dysfunction, including progesterone resistance.
The aim of this study was to investigate the clinical significance of three immune cell-related transcription factors, T-bet, GATA-3 (show GATA3 ELISA Kits) and Bcl-6 in bladder cancer in Tunisian patients.
These findings elucidate a mechanism by which EZH2 (show EZH2 ELISA Kits) and BCL6 cooperate to repress bivalent promoters in germinal center B cells, and provide a rationale for combined treatment with EZH2 (show EZH2 ELISA Kits) and BCL6 inhibitors in patients with DLBCL.
analysis of role of BCL6 in maintaining activated B cell diffuse large B cell lymphoma reveals that ABC (show ABCB6 ELISA Kits)-DLBCL is a BCL6-dependent disease that can be targeted by rationally designed inhibitors that exceed the binding affinity of natural BCL6 ligands
Results provide evidence that BCL6 overexpression is involved in genomic instability in multiple myeloma cells.
the high expressions of BCL6 and Lewis y antigen are associated with development, high tumor burden, and worse prognosis of ovarian cancer and targeting BCL6 could be a novel therapeutic strategy for ovarian cancer treatment.
MicroRNA-544 down-regulates both Bcl6 and Stat3 (show STAT3 ELISA Kits) to inhibit tumor growth of human triple negative breast cancer
miR (show MLXIP ELISA Kits)-10a directly recognizes the 3'-UTR (show UTS2R ELISA Kits) of the BCL6 transcript and regulated BCL6 expression.
The protein encoded by this gene is a zinc finger transcription factor and contains an N-terminal POZ domain. This protein acts as a sequence-specific repressor of transcription, and has been shown to modulate the transcription of START-dependent IL-4 responses of B cells. This protein can interact with a variety of POZ-containing proteins that function as transcription corepressors. This gene is found to be frequently translocated and hypermutated in diffuse large-cell lymphoma (DLCL), and may be involved in the pathogenesis of DLCL. Alternatively spliced transcript variants encoding different protein isoforms have been found for this gene.
B-cell CLL/lymphoma 6
, B-cell CLL/lymphoma 6 (zinc finger protein 51)
, B-cell lymphoma 6 protein
, zinc finger protein 51
, B-cell leukemia/lymphoma 5
, B-cell leukemia/lymphoma 6
, B-cell lymphoma 6 protein homolog
, B-cell lymphoma 5 protein
, B-cell lymphoma 6 protein transcript
, cys-his2 zinc finger transcription factor
, lymphoma-associated zinc finger gene on chromosome 3
, protein LAZ-3
, zinc finger and BTB domain-containing protein 27
, zinc finger transcription factor BCL6S