Browse our BRD4 Proteins (BRD4)

Full name:
Bromodomain Containing 4 Proteins (BRD4)
On www.antibodies-online.com are 8 Bromodomain Containing 4 (BRD4) Proteins from 3 different suppliers available. Additionally we are shipping BRD4 Antibodies (103) and BRD4 Kits (5) and many more products for this protein. A total of 122 BRD4 products are currently listed.
Synonyms:
BRD4, brd4-b, Brd5, CAP, fb18g03, HUNK1, HUNKI, MCAP, WI-11513, wu:fb18g03
list all proteins Gene Name GeneID UniProt
BRD4 23476 O60885
BRD4 57261 Q9ESU6
Rat BRD4 BRD4 362844  

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BRD4 Proteins (BRD4) by Origin

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More Proteins for BRD4 Interaction Partners

Zebrafish Bromodomain Containing 4 (BRD4) interaction partners

  1. Brd4 associates with mitotic chromosomes throughout early zebrafish embryogenesis

Human Bromodomain Containing 4 (BRD4) interaction partners

  1. Chemical degrader of BET bromodomain proteins, dBET6, led to the unexpected identification of BRD4 as master regulator of global transcription elongation in acute T-cell leukemia. BRD4 loss does not directly affect CDK9 (show CDK9 Proteins) localization.

  2. BRD4 binds and stays associated with chromatin during mitosis, bookmarking early G1 genes and reactivating transcription after mitotic silencing. BRD4 acts as a passive scaffold via its recruitment of vital transcription factors and as an active kinase that phosphorylates RNA polymerase II. A model in which BRD4 actively coordinates chromatin structure and transcription is described. Review.

  3. we have discovered that BRD4-bound super-enhancers provide a powerful tool for enriching and prioritizing PC and BC genetic risk loci

  4. BRD4 represses autophagy and lysosome gene expression. This repression is alleviated during nutrient deprivation through AMPK (show PRKAA1 Proteins)-SIRT1 (show SIRT1 Proteins) signaling, allowing autophagy activation. BRD4 inhibition enhances autophagic flux and lysosomal function and promotes the degradation of protein aggregates. Sakamaki et

  5. The studies show that BRD4 inhibition may have therapeutic implications for the treatment of mitochondrial diseases.

  6. The studies show that BRD4 inhibition may have therapeutic implications for the treatment of mitochondrial diseases.

  7. A BRD4 missense mutation was the likely disease-causing mutation in this family with autosomal dominant syndromic congenital cataracts associated with neuro-skeletal anomalies.

  8. these studies highlight the importance of Brd4 in Helicobacter pylori-induced inflammatory gene expression and suggest that Brd4 could be a potential therapeutic target for the treatment of Helicobacter pylori-triggered inflammatory diseases and cancer

  9. BRD4 positively regulates EZH2 (show EZH2 Proteins) transcription through upregulation of C-MYC (show MYC Proteins), and is a novel promising target for pharmacologic treatment in transcriptional program intervention against this intractable disease.

  10. We postulate that BRD4-NUT (B4N) complexes override the preexisting histone code with new posttranslational modifications patterns that reflect aberrant transcription and that epigenetically modulate the nucleosome environment toward the NUT-midline carcinoma (NMC) state.

Mouse (Murine) Bromodomain Containing 4 (BRD4) interaction partners

  1. The functional domains of mouse BRD4 and its role in transcription are described. Review.

  2. Brd2 (show BRD2 Proteins) and Brd4 genetic transcription required for Th17 cell development and adaptive immunity.

  3. These data provide a detailed mechanism for how activated NF-kappaB (show NFKB1 Proteins) and BRD4 control epithelial-mesenchymal transition initiation and transcriptional elongation in model airway epithelial cells in vitro and in a murine pulmonary fibrosis model in vivo.

  4. DOT1L (show DOT1L Proteins), via dimethylated histone H3 (show HIST3H3 Proteins) K79, facilitates histone H4 acetylation, which in turn regulates the binding of BRD4 to chromatin in acute lymphoblastic leukemia.

  5. Acute induction of genes related to lipid accumulation in the livers of mice force-fed with fructose is associated with the induction of histone acetylation and BRD4 binding around these genes

  6. Both mouse and human BRD4 have intrinsic histone acetyltransferase activity.

  7. the interaction between BRD4 and Mediator has functional importance for gene-specific transcriptional activation and for acute myeloid leukemia (show BCL11A Proteins) maintenance.

  8. our data demonstrate the fundamental role of Brd4 in monitoring cell differentiation through its interaction with acetylated histone marks and disruption of Brd4 may cause aberrant differentiation.

  9. Data show that CCAAT-enhancer-binding protein-alpha (C/EBPalpha (show CEBPA Proteins)) directly regulates Kruppel-like factor 4 (Klf4 (show KLF4 Proteins)) expression and increasing the levels of histone demethylase (show MBD2 Proteins) Lsd1 (show KDM1A Proteins) and transcription factor Brd4 in B cell.

  10. BRD4 can act as a global genomic regulator to direct the fibrotic response through its coordinated regulation of myofibroblast transcription.

BRD4 Protein Profile

Protein Summary

The protein encoded by this gene is homologous to the murine protein MCAP, which associates with chromosomes during mitosis, and to the human RING3 protein, a serine/threonine kinase. Each of these proteins contains two bromodomains, a conserved sequence motif which may be involved in chromatin targeting. This gene has been implicated as the chromosome 19 target of translocation t(15\;19)(q13\;p13.1), which defines an upper respiratory tract carcinoma in young people. Two alternatively spliced transcript variants have been described.

Alternative names and synonyms associated with BRD4

  • bromodomain containing 4 (brd4)
  • bromodomain containing 4 (BRD4)
  • bromodomain containing 4 (Brd4)
  • BRD4 protein
  • brd4-b protein
  • Brd5 protein
  • CAP protein
  • fb18g03 protein
  • HUNK1 protein
  • HUNKI protein
  • MCAP protein
  • WI-11513 protein
  • wu:fb18g03 protein

Protein level used designations for BRD4

Bromodomain-containing protein 4B , bromodomain-containing protein 4B , bromodomain containing 4 , bromodomain-containing protein 4 , bromodomain 4 , bromodomain-containing protein 4-like , bromodomain containing protein 4 , bromodomain-containing 4 , chromosome-associated protein , bromodomain-containing 5 , fsh-like protein , mitotic chromosome-associated protein

GENE ID SPECIES
446381 Xenopus laevis
455794 Pan troglodytes
570531 Danio rerio
100062072 Equus caballus
100216259 Xenopus (Silurana) tropicalis
100409351 Callithrix jacchus
100463607 Ailuropoda melanoleuca
100074736 Ornithorhynchus anatinus
100352214 Oryctolagus cuniculus
100533540 Sus scrofa
100593625 Nomascus leucogenys
23476 Homo sapiens
484869 Canis lupus familiaris
614048 Bos taurus
57261 Mus musculus
362844 Rattus norvegicus
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