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Human FOXP3 Protein expressed in HEK-293 Cells - ABIN2721384
Larsen, Munir, Woetmann, Frøsig, Odum, Svane, Becker, Andersen: Functional characterization of Foxp3-specific spontaneous immune responses. in Leukemia 2013
Human FOXP3 Protein expressed in Wheat germ - ABIN1354393
Liu, Liu, Chen, Yang, Liu, Liu, Dugas, Tang, Zheng, Liu, Wang: FOXP3 Controls an miR-146/NF-?B Negative Feedback Loop That Inhibits Apoptosis in Breast Cancer Cells. in Cancer research 2015
analysis of Foxp3-based immunoregulation and autoimmunity in zebrafish
correlation between the expression of t-bet, stat6 (show STAT6 Proteins) and foxp3 with other genes involved in Th and T(reg (show KCNH2 Proteins)) responses
cloning and characterization of the full-length cDNA of Atlantic salmon Foxp3, which possesses a Forkhead domain, a zinc finger domain and a leucine-zipper domain as its counterpart in mammals
Polymorphisms of FoxP3 rs5902434 and rs2232365 were associated with female recurrent respiratory papillomatosis in Koreans.
this paper reviews the role of FOXP3 in autoimmunity
High FOXP3 expression is associated with pancreatic cancer and liver metastases from colorectal cancer.
Hepatitis C virus-associated skin lesions are associated with low frequency of Foxp3+ Treg cells. They are not related to liver enzymes or viral load; however, they are associated with a more advanced gross liver insult.
Results show that the positive rates and expression levels of nestin (show NES Proteins), tyrosine hydroxylase (TH (show TH Proteins)), GFAP (show GFAP Proteins) and IL-17 (show IL17A Proteins) were significantly decreased while Foxp3 and the ratio of Foxp3/IL-17 (show IL17A Proteins) were statistically elevated in BM of AML (show RUNX1 Proteins) patients.
FOXP3-positive gastric adenocarcinoma patients had significantly increased overall survival and disease-free survival rates. p21 (show CDKN1A Proteins) expression showed a significant positive correlation with tumoral FOXP3 expression in gastric adenocarcinoma cells.
These results underline the particular genetic background of the Tunisian endemic PF and suggest the implication of FOXP3 gene in the susceptibility and the clinical course of the disease.
this study shows that abnormal expression of miR (show MLXIP Proteins)-125a-5p and its effect on foxp3 expression are likely involved in the pathogenesis of thymoma-associated myasthenia gravis
both FOXP3 rs5902434 genotypes and alleles were differently distributed in COPD (show ARCN1 Proteins) patients and smokers with normal lung function. The distribution of del/del genotype was associated with systemic expression ofFOXP3mRNA
FOXP3 overexpression promoted cell proliferation, migration, and invasion in increased TGF-beta (show TGFB1 Proteins) expression and secretion in gastric cancer cells, while FOXP3 knockdown suppressed these effects.
Mechanistic analysis indicated that E47 (show TCF3 Proteins) activated expression of the transcription factor Spi-B (show SPIB Proteins) and the suppressor of cytokine signaling 3 (SOCS3 (show SOCS3 Proteins)), which both downregulated Foxp3 expression. These findings demonstrate that the balance of Id3 (show ID3 Proteins) and E47 (show TCF3 Proteins) controls the maintenance of Foxp3 expression in Treg cells and, thus, contributes to Treg cell plasticity.
Foxp3 expression in lung epithelial cells, and not in Treg cells, inhibited OVA- and cockroach extract-induced asthma.
Regulatory T cells have a high apoptosis rate ex vivo correlating with low c-FLIP (show CFLAR Proteins) expression.
Forkhead box P3 protein (FoxP3) acts in multimodal fashion to directly activate or repress transcription, in a context- and partner-dependent manner, to govern Treg cell phenotypes.
Membrane-bound DKK-1 (show DKK1 Proteins) is a novel Foxp3 postive Treg cell derived mediator to maintain immunological tolerance in T-cell-mediated autoimmune colitis.
A384T mutation associated with autoimmune IPEX syndrome, induces a distinctive tissue-restricted inflammation by specifically impairing the ability of Treg cells to compete with pathogenic T cells
Systemic NRF2 (show NFE2L2 Proteins) activation by Keap1 (show KEAP1 Proteins) knockdown alleviates multiple-organ inflammation and improves the survival rate of Sf mice.
CTLA-4 (show CTLA4 Proteins) expressed by FOXP3(+) regulatory T cells prevents inflammatory tissue attack and not T-cell priming in arthritis.
Inhibition of IL-27p28 also enhanced the suppressive capacity of adoptively transferred CD4 (show CD4 Proteins)(+) nTregs by increasing the stability of Foxp3 expression.
This study suggests that the epigenetic modification of FOXP3 gene is involved in the pathogenesis of EAE.
sequenced the entire Foxp3 cDNA which is 1296 nucleotides in length and codes for a polypeptide of 432 amino acids
In a miniature swine lung transplantation model, the FOXP3 mRNA level in the peripheral blood was upregulated at an early phase of rejection
Experimental infection with bovine viral diarrhea virus did not provide evidence ofTreg activation based on expression of FoxP3 and CTLA4 (show CTLA4 Proteins).
The expression of Foxp3 in CD4 (show CD4 Proteins)(+) T cells from persistent lymphocytotic cattle was significantly increased.
There is a positive correlation between the intensity of CD25 (show IL2RA Proteins) expression and the expression of the transcription Foxp3 factor in bovine CD8 (show CD8A Proteins)(+) cells.
identification of Foxp3 expression in Treg cells
These findings revealed that despite the existence of a distinct bovine CD4 (show CD4 Proteins)(+)CD25 (show IL2RA Proteins)(high) T cell population, which showed Foxp3 transcription/expression, natural regulatory activity did not reside in this cell population
The correlation of TH17-related TLR4 (show TLR4 Proteins) expression and Foxp3-positive cells in the rectal tissue of horses with inflammatory bowel disease is reported.
Expression levels of FOXP3 mRNA copy numbers were significantly increased in lesional compared to tumour-distant samples. There was no difference in FOXP3 expression in tumour-distant samples from equine sarcoid- compared with control horses.
results confirm FoxP3 expression in the horse, in contrast to the mouse, is regulated similarly to FOXP3 expression in humans and provide evidence that FoxP3 expression by conventional T cells may help regulate the developing immune response
The protein encoded by this gene is a member of the forkhead/winged-helix family of transcriptional regulators. Defects in this gene are the cause of immunodeficiency polyendocrinopathy, enteropathy, X-linked syndrome (IPEX), also known as X-linked autoimmunity-immunodeficiency syndrome. Alternatively spliced transcript variants encoding different isoforms have been identified.
forkhead box protein P3
, regulatory protein Foxp3
, forkhead box P3
, forkhead box protein P3-like
, transcription factor foxp3
, immune dysregulation, polyendocrinopathy, enteropathy, X-linked
, immunodeficiency, polyendocrinopathy, enteropathy, X-linked
, forkhead/winged helix transcription factor 3