Browse our MEN1 Proteins (MEN1)

Full name:
Multiple Endocrine Neoplasia I Proteins (MEN1)
On www.antibodies-online.com are 3 Multiple Endocrine Neoplasia I (MEN1) Proteins from 3 different suppliers available. Additionally we are shipping MEN1 Antibodies (108) and MEN1 Kits (1) and many more products for this protein. A total of 115 MEN1 products are currently listed.
Synonyms:
AW045611, MEAI, menin, SCG2
list all proteins Gene Name GeneID UniProt
Mouse MEN1 MEN1 17283 O88559
MEN1 4221 O00255
MEN1 29417 Q9WVR8

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MEN1 Proteins (MEN1) by Origin

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Mouse (Murine) Multiple Endocrine Neoplasia I (MEN1) interaction partners

  1. Inactivation of Kmt2a (show MLL Proteins) in Men1-deficient mice accelerated pancreatic islet tumorigenesis and shortened the average life span. Increases in cell proliferation were observed in mouse pancreatic islet tumors upon inactivation of both Kmt2a (show MLL Proteins) and Men1.

  2. Data suggest that menin inhibits differentiation into terminal effectors and positively controls proliferation and survival of Ag-specific CD8 (show CD8A Proteins)(+) T cells that are activated upon infection; study uncovered an important role for menin in the immune response of CD8 (show CD8A Proteins)(+) T cells to infection

  3. Our data further confirms that deletion of Men1 alone does not favour carcinoid development, but rather cooperates with additional loci.

  4. Menin binds on the promoter of Inhbb (show INHBB Proteins) gene where it favours the recruitment of Ezh2 (show EZH2 Proteins) via an indirect mechanism involving Akt (show AKT1 Proteins)-phosphorylation.

  5. Results indicate that fasted male Men1(+/-) mice, in the early stage of development of MEN1, display glucose metabolic disorders. These disorders are caused not by direct induction of insulin (show INS Proteins) resistance, but via increased glucagon (show GCG Proteins) secretion and the consequent stimulation of hepatic glucose production.

  6. The inactivation of menin in the thyroid gland of young mice does not seem to change the histological pattern, but it influences the proliferation of follicular cells. Further molecular studies especially in aged mice are needed to better understand the correlation between certain oncogenes and the inactive status of menin.

  7. Data show that progranulin (show GRN Proteins) is upregulated in neuroendocrine tumors (NETs) and islets of the multiple endocrine neoplasia 1 protein (MEN1) mouse as well as in the serum of patients with pancreatic NETs associated with glucagonoma syndrome.

  8. Although mice lacking Men1 developed insulinomas as expected, elimination of ARC (show NOL3 Proteins) in this context did not significantly alter tumor load. Cellular rates of proliferation and death in these tumors were also not perturbed in the absence of ARC (show NOL3 Proteins).

  9. The study characterized the binding position of Ezh2 (show EZH2 Proteins) and menin at all annotated genes in embryonic stem cells and B and T lymphocytes.

  10. Data demonstrate that loss of Men1 in pancreatic islet cells alters the epigenetic landscape of its target genes during early stages of pancreatic neuroendocrine tumor formation.

Human Multiple Endocrine Neoplasia I (MEN1) interaction partners

  1. Loss of Menin is an early event in pancreatic neuroendocrine tumorigenesis and that ATRX (show ATRX Proteins)/DAXX (show DAXX Proteins) loss and alternative lengthening of telomeres are relatively late events.

  2. The lack of somatic CDKN1B (show CDKN1B Proteins) mutations in our samples points to a rare involvement in parathyroid adenomas, despite the frequent loss of nuclear p27 (show PAK2 Proteins) expression. MEN1 biallelic inactivation seems to be directly related to down-regulation of p27 (show PAK2 Proteins) expression through the inhibition of CDKN1B (show CDKN1B Proteins) gene transcription.

  3. This result shows a novel mechanism whereby menin, a RNA-binding protein, facilitates the processing of its specific miRNA by regulating the dynamics of the menin-miR-24 Gene Regulatory Network at the level of pri-miRNA processing.

  4. findings reveal a previously unappreciated cross-talk between two crucial tumor suppressor genes, MEN1 and DAXX (show DAXX Proteins), thought to work by independent pathways

  5. Multiple endocrine neoplasia type 1-related primary hyperparathyroidism patients experienced more common kidney complications but less skeletal issues, and a milder biochemical manifestation compared with SHPT patients. MEN1 mutation detection rate was 79.4% and 9 of the identified mutations were novel.

  6. miR (show MLXIP Proteins)-24-dependent expression of menin may be important in the regulation of nonmalignant and cholangiocarcinoma proliferation.

  7. rs2959656, a nonsynonymous variant in MEN1, is associated with the development of clinically active pituitary adenoma.

  8. Study acts as a further supplement of the genetic features of neuroendocrine tumors. Somatic mutations of three potential tumor-related genes (HRAS (show HRAS Proteins), PAK1 (show PAK1 Proteins) and MEN1) might contribute to the tumorigenesis of thymic neuroendocrine tumors with EAS.

  9. The results and clinical course of disease in this case indicate the potential role of menin in the development of non-endocrine or atypical-endocrine tumors in MEN1 patients.

  10. cellular staining for menin also reveals the distribution of menin in the cell membrane and the punctate-like cell organelles

MEN1 Protein Profile

Protein Summary

This gene encodes menin, a putative tumor suppressor associated with a syndrome known as multiple endocrine neoplasia type 1. In vitro studies have shown menin is localized to the nucleus, possesses two functional nuclear localization signals, and inhibits transcriptional activation by JunD, however, the function of this protein is not known. Two messages have been detected on northern blots but the larger message has not been characterized. Alternative splicing results in multiple transcript variants.

Alternative names and synonyms associated with MEN1

  • multiple endocrine neoplasia I (men1)
  • multiple endocrine neoplasia I (MEN1)
  • multiple endocrine neoplasia 1 (Men1)
  • multiple endocrine neoplasia I (Men1)
  • AW045611 protein
  • MEAI protein
  • menin protein
  • SCG2 protein

Protein level used designations for MEN1

multiple endocrine neoplasia 1 , menin , multiple endocrine neoplasia I , menin-like , multiple endocrine neoplasia protein

GENE ID SPECIES
549115 Xenopus (Silurana) tropicalis
692344 Felis catus
743979 Pan troglodytes
100158320 Xenopus laevis
100411101 Callithrix jacchus
100441476 Pongo abelii
100472417 Ailuropoda melanoleuca
100538227 Danio rerio
17283 Mus musculus
4221 Homo sapiens
29417 Rattus norvegicus
483758 Canis lupus familiaris
100523533 Sus scrofa
539431 Bos taurus
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