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Human Polyclonal PCGF2 Primary Antibody for ELISA, WB - ABIN249894
Ishida, Asano, Hasegawa, Koseki, Ono, Yoshida, Taniguchi, Kanno: Cloning and chromosome mapping of the human Mel-18 gene which encodes a DNA-binding protein with a new 'RING-finger' motif. in Gene 1993
Suggest a novel role of PCGF2 in arsenic trioxide-mediated degradation of PML (show PML Antibodies)-RARA (show RARA Antibodies) that PCGF2 might act as a negative regulator of UBE2I (show UBE2I Antibodies) via direct interaction.
Mel-18 underexpression in luminal breast cancer cells caused ER-alpha (show ESR1 Antibodies) downregulation.Its overexpression restored it in triple-negative breast cancer cells. MEL-18 suppressed SUMOylation of the ESR1 (show ESR1 Antibodies) transactivators p53 (show TP53 Antibodies) and SP1 (show PSG1 Antibodies).
It was therefore concluded that the lower Mel-18 expression might contribute to colorectal cancer development/progression.
Mel-18 functions as a tumor suppressor by its novel negative control of the epithelial-mesenchymal transition in breast cancer.
Findings suggest that Mel-18 is a novel negative regulator of breast cancer stem cell (CSC) that inhibits the stem cell population and in vitro and in vivo self-renewal through the inactivation of Wnt (show WNT2 Antibodies)-mediated Notch (show NOTCH1 Antibodies) signaling.
PCGF2, a PRC1 (show PRC1 Antibodies) gene, played a negative role in the granulocytic differentiation of human APL (show FASL Antibodies) cells.
these findings provide that Mel-18 is a novel regulator of tumor angiogenesis through regulating HIF-1alpha (show HIF1A Antibodies) and its target VEGF (show VEGFA Antibodies) expressions mediated by the PTEN (show PTEN Antibodies)/PI3K (show PIK3CA Antibodies)/Akt (show AKT1 Antibodies) pathway, suggesting a new tumor-suppressive role of Mel-18 in human breast cancer.
Loss of Mel-18 is associated with prostate cancer.
Our analysis showed correlation between BMI1 (show BMI1 Antibodies) and PCGF2 gene's expression and survival in children with medulloblastoma.
Bmi-1 (show BMI1 Antibodies)/Mel-18 ratio can be potentially used as a tool for stratifying women at risk of developing breast malignancy.
Data indicate that Bmi1 (show BMI1 Antibodies) and Mel18 have opposing functions and are present in distinct complexes.
Mel-18 controls the enrichment of tumor-initiating cells in side population fraction in mouse mammary gland cancer.
Data show that Mel-18 and Ezh2 (show EZH2 Antibodies) positively regulate the expression of Il17a (show IL17A Antibodies) and Il17f (show IL17F Antibodies).
Chemokine (show CCL1 Antibodies)-mediated thymopoiesis is regulated by a mammalian Polycomb (show CBX2 Antibodies) group gene, mel-18
the stoichiometry and/or equilibrium of subunits of the class II Polycomb complex containing Mel-18 might be regulated by changes in phosphorylation status via the PKC signaling pathway
Results provide genetic evidence that Cited2 (show CITED2 Antibodies) controls the expression of INK4a/ARF (show CDKN2A Antibodies) and fibroblast proliferation, at least in part via the polycomb (show CBX2 Antibodies)-group genes Bmi1 (show BMI1 Antibodies) and Mel18.
Loss or knockdown of mel-18 leads to the expression of Hoxb4 (show HOXB4 Antibodies), an increase in the proportion of hematopoietic stem cells in G0 phase, and the subsequent promotion of HSC (show FUT1 Antibodies) self-renewal.
Mel-18 contributes to the maintenance of the active state of the Hes-1 gene as a cellular memory system, thereby supporting the expansion of early T lymphocyte progenitors.
Sf3b1 (show SF3B1 Antibodies)-Zfp144 protein interaction is essential for true Polycomb (show CBX2 Antibodies) group proteins mediated repression of Hox (show MSH2 Antibodies) genes.
observed that expression of the PcG genes-bmi1 (show BMI1 Antibodies) and mel-18-is correlated with self-renewal and differentiation of HSCs. Thus, it was suggested that the balance between Bmi1 (show BMI1 Antibodies) and Mel-18 regulates self-renewal of HSCs
The protein encoded by this gene contains a RING finger motif and is similar to the polycomb group (PcG) gene products. PcG gene products form complexes via protein-protein interaction and maintain the transcription repression of genes involved in embryogenesis, cell cycles, and tumorigenesis. This protein was shown to act as a negative regulator of transcription and has tumor suppressor activity. The expression of this gene was detected in various tumor cells, but is limited in neural organs in normal tissues. Knockout studies in mice suggested that this protein may negatively regulate the expression of different cytokines, chemokines, and chemokine receptors, and thus plays an important role in lymphocyte differentiation and migration, as well as in immune responses.
polycomb group RING finger protein 2
, zinc finger protein 144 (Mel-18) (human homolog)
, polycomb group ring finger 2
, ring finger protein 110
, DNA-binding protein Mel-18
, zinc finger protein 144
, melanoma nuclear protein 18