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anti-Rat (Rattus) PRMT5 Antibodies:
anti-Human PRMT5 Antibodies:
anti-Mouse (Murine) PRMT5 Antibodies:
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Dog (Canine) Monoclonal PRMT5 Primary Antibody for IF, WB - ABIN968581
Gilbreth, Yang, Bartholomeusz, Pimental, Kansra, Gadiraju, Marcus: Negative regulation of mitosis in fission yeast by the shk1 interacting protein skb1 and its human homolog, Skb1Hs. in Proceedings of the National Academy of Sciences of the United States of America 1999
Show all 3 Pubmed References
Dog (Canine) Monoclonal PRMT5 Primary Antibody for IF, WB - ABIN968582
Krapivinsky, Pu, Wickman, Krapivinsky, Clapham: pICln binds to a mammalian homolog of a yeast protein involved in regulation of cell morphology. in The Journal of biological chemistry 1998
Show all 3 Pubmed References
Human Polyclonal PRMT5 Primary Antibody for IHC (p), IHC - ABIN258206
Pak, Lee, Roh: High nuclear expression of protein arginine methyltransferase-5 is a potentially useful marker to estimate submucosal invasion in endoscopically resected early colorectal carcinoma. in Pathology international 2015
Human Polyclonal PRMT5 Primary Antibody for WB - ABIN4347350
Guo, Zheng, Xu, Dai, Zhou, Pascua, Chen, Shen: Methylation of FEN1 suppresses nearby phosphorylation and facilitates PCNA binding. in Nature chemical biology 2010
Human Polyclonal PRMT5 Primary Antibody for ELISA, WB - ABIN451788
Zhao, Rank, Tan, Li, Moritz, Simpson, Cerruti, Curtis, Patel, Allis, Cunningham, Jane: PRMT5-mediated methylation of histone H4R3 recruits DNMT3A, coupling histone and DNA methylation in gene silencing. in Nature structural & molecular biology 2009
The results suggested that medaka Mep50 (show WDR77 Antibodies) could be a partner of Prmt5 and might play major roles in a variety of tissues in medaka.
SFN (show SFN Antibodies) treatment of tumors results in reduced MEP50 (show WDR77 Antibodies) level and H4R3me2s formation, confirming that that SFN (show SFN Antibodies) impacts this complex in vivo. These studies suggest that the PRMT5/MEP50 (show WDR77 Antibodies) is required for tumor growth and that reduced expression of this complex is a part of the mechanism of SFN (show SFN Antibodies) suppression of tumor formation.
High nuclear PRMT5 expression is associated with oropharyngeal squamous cell carcinoma.
High PRMT5 expression is associated with prostate cancer.
Results provide evidence that PRMT5 and p44 regulate gene expression of growth and anti-growth factors to promote lung tumorigenesis.
PRMT5 regulates internal ribosome entry site-dependent translation via methylation of hnRNP A1 (show HNRNPA1 Antibodies).
PRMT5 knockdown reduces growth, survival, and colony formation of chronic myelogenous leukemia CD34 (show CD34 Antibodies)+ cells.
Methylation of RUVBL1 (show RUVBL1 Antibodies) by the arginine methyltransferase PRMT5 is required for homologous recombination-mediated double-strand break repair by promoting TIP60 (show KAT5 Antibodies)-mediated histone H4K16 acetylation.
findings show that PRMT5 is an important modulator of CD4 (show CD4 Antibodies)(+) T cell expansion; PRMT5 was transiently upregulated during maximal proliferation of mouse and human memory Th cells; data implicate PRMT5 in the regulation of adaptive memory Th cell responses
Results provide evidence that PRMT5 differentially regulates self-renewal, survival and proliferation of primary glioblastoma neurosphere cells (GBMNS)
PRMT5 regulated the production of inflammatory factors, cell proliferation, migration and invasion of rheumatoid arthritis fibroblast-like synoviocytes.
a combinatorial role of PRMT4/CARM1 (show CARM1 Antibodies) and PRMT5 for proper myogenesis in zebrafish
Data indicate that MEP50 (show WDR77 Antibodies) WD repeat protein (show DCAF7 Antibodies) is essential for methylation of histones H4 and H2A (show H2AFX Antibodies) by PRMT5 arginine methyltransferase.
data support a mechanism in which MEP50 (show WDR77 Antibodies) binds substrate and stimulates PRMT5 activity modulated by substrate post-translational modifications
Protein arginine methyltransferase Prmt5-Mep50 (show WDR77 Antibodies) methylates histones H2A (show H2AFX Antibodies) and H4 and the histone chaperone nucleoplasmin (show NPM1 Antibodies) in Xenopus laevis eggs
PRMT5 maintains progenitor cells through its regulation of Bmp4 (show BMP4 Antibodies); adult and embryonic stem cells also require PRMT5 for maintaining pluripotency, suggesting that similar mechanisms might regulate lineage-restricted progenitor cells during organogenesis.
Menin and PRMT5 suppress GLP1R (show GLP1R Antibodies) transcript levels and PKA-mediated phosphorylation of FOXO1 (show FOXO1 Antibodies) and CREB (show CREB1 Antibodies).
Prmt5 facilitates promoter-enhancer looping and gene expression at the PPARgamma2 (show PPARG Antibodies) locus, which encodes a critical lineage-determining factor that drives the differentiation of adipose tissue.
Taken together, our data reveal a pathophysiologically relevant role for PRMT5 in MHC II transactivation in macrophages
Prmt5 is required for germ cell survival during spermatogenesis in mice.
Prmt5 controls proliferation of adult muscle stem cells by direct epigenetic silencing of the cell cycle inhibitor (show CDKN2A Antibodies) p21 (show D4S234E Antibodies).
Prmt5 plays critical roles in germ cell development that are required for germ cell survival during embryonic stages
results demonstrate that PRMT5 plays distinct roles in the behavior of HSCs compared with HPCs and is essential for the maintenance of adult hematopoietic cells.
It show the morphological and functional phenotypes of single or double null alleles of prmt-5 in Caenorhabditis elegans. The prmt-1 (show PRMT1 Antibodies);prmt-5 double mutants are viable, and exhibit short body length and small brood size compared to N2 and each of the single mutants.
The PRMT-5 catalyzes the symmetric dimethylation of substrates containing monomethylarginine residues in vivo.
Analysis of prmt-5-deficient worms indicated that methylation promoted the dopamine-mediated modulation of chemosensory and locomotory behaviors through the DOP (show COPB2 Antibodies)-3 receptor.
data confirm that MEP50 (show WDR77 Antibodies) plays a key role in substrate recognition and activates PRMT5 activity by increasing its affinity for protein substrates.
the substrate specificity, processivity, and kinetic mechanism of bacterially expressed Caenorhabditis elegans PRMT5 (cPRMT5).
analysis of structural insights into protein arginine symmetric dimethylation by PRMT5
PRMT-5 represses CEP-1 transcriptional activity through CBP-1, which represents a novel regulatory mechanism of p53 (show TP53 Antibodies)-dependent apoptosis.
Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA), with a preference for the formation of MMA. Specifically mediates the symmetrical dimethylation of arginine residues in the small nuclear ribonucleoproteins Sm D1 (SNRPD1) and Sm D3 (SNRPD3)\; such methylation being required for the assembly and biogenesis of snRNP core particles. Methylates SUPT5H. Mono- and dimethylates arginine residues of myelin basic protein (MBP) in vitro. Plays a role in the assembly of snRNP core particles. May play a role in cytokine-activated transduction pathways. Negatively regulates cyclin E1 promoter activity and cellular proliferation. May regulate the SUPT5H transcriptional elongation properties. May be part of a pathway that is connected to a chloride current, possibly through cytoskeletal rearrangement. Methylates histone H2A and H4 'Arg-3' during germ cell development. Methylates histone H3 'Arg-8', which may repress transcription. Methylates the Piwi proteins (PIWIL1, PIWIL2 and PIWIL4), methylation of Piwi proteins being required for the interaction with Tudor domain-containing proteins and subsequent localization to the meiotic nuage. Methylates RPS10. Attenuates EGF signaling through the MAPK1/MAPK3 pathway acting at 2 levels. First, monomethylates EGFR\; this enhances EGFR 'Tyr-1197' phosphorylation and PTPN6 recruitment, eventually leading to reduced SOS1 phosphorylation. Second, methylates RAF1 and probably BRAF, hence destabilizing these 2 signaling proteins and reducing their catalytic activity (By similarity). Required for induction of E-selectin and VCAM-1, on the endothelial cells surface at sites of inflammation (By similarity). Methylates HOXA9 (By similarity).
protein arginine methyltransferase 5
, protein arginine N-methyltransferase 5
, SKB1 homolog
, shk1 kinase-binding protein 1 homolog
, histone-arginine N-methyltransferase PRMT5
, putative arginine N-methyltransferase, type II
, protein arginine methyltransferase
, protein arginine N-methyltransferase 5-like
, 72 kDa ICln-binding protein
, HMT1 hnRNP methyltransferase-like 5
, jak-binding protein 1
, Jak-binding protein 1