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Adenocarcinomas or adenomas derived from pigmented ciliary epithelium is distinguished from uveal melanoma by the absence of SOX10 expression and presence of the BRAF (show BRAF Proteins) V600E mutation.
Therefore, the mutant cannot transactivate the MITF (show MITF Proteins) promoter effectively, inhibiting melanin synthesis and leading to WS2 (show MITF Proteins). Our study confirmed haploinsufficiency as the underlying pathogenesis for WS2 (show MITF Proteins).
Sox10 labeling is seen in a subset of metastatic triple-negative breast carcinomas, supporting its use as a marker of breast origin in this setting.
SOX10 is useful in the differential diagnosis of salivary gland neoplasms.
An extended immunohistochemical panel that includes beta-catenin (show CTNNB1 Proteins) and SOX10 helps to support the diagnosis of biphenotypic sinonasal sarcoma without the need for gene rearrangement studies.
found that all SOX10-NL-positive cells expressed an early neural crest marker NGFR (show NGFR Proteins), however SOX10-NL-positive cells purified from differentiated hiPS cells progressively attenuate their NL-expression under proliferation
The expression of the endogenous transcript is induced in a heterologous cell line by ectopically expressing SOX10, and is nearly ablated in Schwann cells by impairing SOX10 function. Intriguingly, overexpressing the two MTMR2 (show MTMR2 Proteins) protein isoforms in HeLa cells revealed that both localize to nuclear puncta and the shorter isoform displays higher nuclear localization compared to the longer isoform
This study assesses MYB (show MYB Proteins), CD117 and SOX-10 expression in cutaneous adnexal tumors.
Our zebrafish CHARGE model thus reveals important regulatory roles for Chd7 at multiple points of neural crest development viz., migration, fate choice and differentiation and we suggest that sox10 deregulation is an important driver of the neural crest-derived aspects of Chd7 dependent CHARGE syndrome.
Data indicate that transcription factors Sox10 and Olig2 (show OLIG2 Proteins) play key roles in oligodendrocytes (OLs) specification.
The activity of Sox-10 transcription factor is well conserved and is regulated by SUMOylation.
This study demonstrates that Sox10(+) cells contribute to pericytes and smooth muscle cells in most parts of the body, including those from neural crest and non-neural crest, which has significant implications in vascular remodeling under physiological and pathological conditions.
Chd7 coordinates with Sox10 to regulate the initiation of myelinogenesis and acts as a molecular nexus of regulatory networks that account for the development of a seemingly diverse array of lineages, including oligodendrocytes and osteoblasts, pointing to previously uncharacterized Chd7 functions.
We discovered that Tead1 (show TEAD1 Proteins) and co-activators Yap (show YAP1 Proteins) and Taz (show TAZ Proteins) are required for Pmp22 (show PMP22 Proteins) expression, as well as for the expression of Egr2 (show EGR2 Proteins) Tead1 (show TEAD1 Proteins) directly binds Pmp22 (show PMP22 Proteins) and Egr2 (show EGR2 Proteins) enhancers early in development and Tead1 (show TEAD1 Proteins) binding is induced during myelination, correlating with Pmp22 (show PMP22 Proteins) expression. The data identify Tead1 (show TEAD1 Proteins) as a novel regulator of Pmp22 (show PMP22 Proteins) expression during development in concert with Sox10 and Egr2 (show EGR2 Proteins)
SOX10 directly activates MCM5 (show MCM5 Proteins) transcription by binding to conserved SOX10 consensus DNA sequences in the MCM5 (show MCM5 Proteins) promoter.
Control of differentiation of mouse enteric nervous system progenitor cells by EDN3 requires regulation of Ednrb expression by SOX10 and ZEB2.
Kaiso (show ZBTB33 Proteins) and Sox10 sequentially interact with Tcf7l2 (show TCF7L2 Proteins) to coordinate the maturation of oligodendrocyte.
Findings uncover a central role of SOX10 as a global regulator of gene expression in the melanocyte lineage by targeting diverse regulatory pathways.
Ets1 (show ETS1 Proteins) and Sox10 interact to promote proper melanocyte and enteric ganglia development from the neural crest.
Sox10(rtTA/+) driven reporter expression in the cochlea persists for at least 54 days after cessation of neonatal induction
Disrupted SOX10 function causes spongiform neurodegeneration in gray tremor mice.
This study reveals a unique regulatory mechanism, the Rgs2 (show RGS2 Proteins)-Ppard (show PPARD Proteins)-Sox10 signaling cascade, and defines a key molecular regulator, Rgs2 (show RGS2 Proteins), in neural crest development.
Demonstrate a contribution of sox10-dependent cranial neural crest to olfactory sensory neurons in zebrafish and provide important insights into the assembly of the nascent olfactory system.
Data indicate that the optical flow analysis detected and quantified significant differences in the cell migrations of Sox10:EGFP positive cranial neural crest cells in ethanol treated versus untreated embryos.
Sox10 might not be required for neural crest formation but is important for later steps during neural crest development.
prdm1a (show PRDM1 Proteins) Regulates sox10 and islet1 (show ISL1 Proteins) in the development of neural crest and Rohon-Beard sensory neurons.
Sox10 function is necessary for the survival of myelinating oligodedrocytes subsequent to axon wrapping but is not required for the survival of nonmyelinating oligodendrocyte progenitor cells.
Phox2b (show PHOX2B Proteins) function is sox10-dependent in the developing enteric nervous system
Decrement of function of foxd3 and/or sox10, two genes important for the development and specification of neural crest, resulted in a reduction and/or loss of GnRH cells of the midbrain, as well as a reduction in the number of terminal nerve GnRH cells.
Data show that expression of Mitf (show MITF Proteins) rescues pigmentation fully in zebrafish, but only partially in Sox10-mutant mice.
This gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional activator after forming a protein complex with other proteins. This protein acts as a nucleocytoplasmic shuttle protein and is important for neural crest and peripheral nervous system development. Mutations in this gene are associated with Waardenburg-Shah and Waardenburg-Hirschsprung disease.
, SRY (sex determining region Y)-box 10
, transcription factor Sox-10
, transcription factor SOX-10-like
, transcription factor sox10
, SRY-related HMG-box gene 10
, dominant megacolon, mouse, human homolog of
, transcription factor SOX-10
, SRY-box containing gene 10
, Sry-boxntranscription factor, SOX-10
, SRY-box 10
, transcription factor Sox10
, dominant megacolon
, transcription factor SOX-M