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Sonic Hedgehog Proteins

(Sonic Hedgehog (SHH))
This gene encodes a protein that is instrumental in patterning the early embryo. It has been implicated as the key inductive signal in patterning of the ventral neural tube, the anterior-posterior limb axis, and the ventral somites. Of three human proteins showing sequence and functional similarity to the sonic hedgehog protein of Drosophila, this protein is the most similar. The protein is made as a precursor that is autocatalytically cleaved\; the N-terminal portion is soluble and contains the signalling activity while the C-terminal portion is involved in precursor processing. More importantly, the C-terminal product covalently attaches a cholesterol moiety to the N-terminal product, restricting the N-terminal product to the cell surface and preventing it from freely diffusing throughout the developing embryo. Defects in this protein or in its signalling pathway are a cause of holoprosencephaly (HPE), a disorder in which the developing forebrain fails to correctly separate into right and left hemispheres. HPE is manifested by facial deformities. It is also thought that mutations in this gene or in its signalling pathway may be responsible for VACTERL syndrome, which is characterized by vertebral defects, anal atresia, tracheoesophageal fistula with esophageal atresia, radial and renal dysplasia, cardiac anomalies, and limb abnormalities. Additionally, mutations in a long range enhancer located approximately 1 megabase upstream of this gene disrupt limb patterning and can result in preaxial polydactyly. [provided by RefSeq, Jul 2008].
Sonic Hedgehog Protein (SHH) (AA 24-197, Cys24IleIle-Mutant) Sonic Hedgehog Protein (SHH) (AA 24-197, Cys24IleIle-Mutant) Sonic Hedgehog Protein (SHH) (AA 24-197, Cys24IleIle-Mutant) (ABIN2018361)

SHH Origin: Human Host: Escherichia coli (E. coli) Recombinant > 95 % by SDS-PAGE and HPLC analyses. Active

Sonic Hedgehog Protein (SHH) (AA 25-198, Cys25IleIle-Mutant) Sonic Hedgehog Protein (SHH) (AA 25-198, Cys25IleIle-Mutant) Sonic Hedgehog Protein (SHH) (AA 25-198, Cys25IleIle-Mutant) (ABIN2018373)

SHH Origin: Mouse Host: Escherichia coli (E. coli) Recombinant > 95 % by SDS-PAGE and HPLC analyses. Active

Sonic Hedgehog Protein (SHH) Sonic Hedgehog Protein (SHH) Sonic Hedgehog Protein (SHH) (ABIN5509475)

SHH Origin: Human Host: Escherichia coli (E. coli) Recombinant >95 % as determined by SDS-PAGE Func Active

Sonic Hedgehog Proteins by Grade

Find Sonic Hedgehog Proteins with a specific Grade. The Grade listed below are among those available. Click on a link to go to the corresponding products.

Sonic Hedgehog Proteins by Origin

Find Sonic Hedgehog Proteins for a variety of species such as anti-Human Sonic Hedgehog, anti-Mouse Sonic Hedgehog, anti-Rat Sonic Hedgehog. The species listed below are among those available. Click on a link to go to the corresponding products.

Sonic Hedgehog Proteins by Source

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Sonic Hedgehog Proteins by Protein Type

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Sonic Hedgehog Proteins by Application

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Sonic Hedgehog Proteins by Biological Activity

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Popular Sonic Hedgehog Proteins

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source Escherichia coli (E. coli)
Validations
  • (3)
Cat. No. ABIN2018361
Quantity 50 μg
Datasheet Datasheet
Reactivity Mouse
Source Escherichia coli (E. coli)
Validations
  • (3)
Cat. No. ABIN2018373
Quantity 50 μg
Datasheet Datasheet
Reactivity Human
Source Escherichia coli (E. coli)
Validations
  • (2)
Cat. No. ABIN5509475
Quantity 30 μg
Datasheet Datasheet
Reactivity Human
Source Escherichia coli (E. coli)
Validations
  • (2)
Cat. No. ABIN7275581
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Source HEK-293 Cells
Validations
  • (1)
  • (1)
Cat. No. ABIN2181760
Quantity 50 μg
Datasheet Datasheet
Reactivity Mouse
Source Escherichia coli (E. coli)
Validations
  • (1)
Cat. No. ABIN5509275
Quantity 25 μg
Datasheet Datasheet
Reactivity Human
Source Escherichia coli (E. coli)
Validations
  • (1)
Cat. No. ABIN7125172
Quantity 50 μg
Datasheet Datasheet
Reactivity Mouse
Source Escherichia coli (E. coli)
Validations
  • (1)
Cat. No. ABIN3123150
Quantity 1 mg
Datasheet Datasheet
Reactivity Human
Source Escherichia coli (E. coli)
Validations
  • (1)
Cat. No. ABIN3077106
Quantity 1 mg
Datasheet Datasheet
Reactivity Human
Source Escherichia coli (E. coli)
Validations
  • (1)
Cat. No. ABIN3077105
Quantity 1 mg
Datasheet Datasheet
Reactivity Mouse
Source Insect Cells
Validations
  • (1)
Cat. No. ABIN3123152
Quantity 1 mg
Datasheet Datasheet
Reactivity Human
Source Insect Cells
Validations
  • (1)
Cat. No. ABIN3077104
Quantity 1 mg
Datasheet Datasheet
Reactivity Mouse
Source Escherichia coli (E. coli)
Validations
  • (1)
Cat. No. ABIN6700560
Quantity 5 μg
Datasheet Datasheet
Reactivity Human
Source Escherichia coli (E. coli)
Validations
  • (1)
Cat. No. ABIN666981
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1319947
Quantity 10 μg
Datasheet Datasheet

Latest Publications for our Sonic Hedgehog Proteins

Kaushal, Popli, Sankhwar, Shukla, Dwivedi: "Sonic hedgehog protects endometrial hyperplasial cells against oxidative stress via suppressing mitochondrial fission protein dynamin-like GTPase (Drp1)." in: Free radical biology & medicine, Vol. 129, pp. 582-599, (2018) (PubMed).

Aliases for Sonic Hedgehog Proteins

sonic hedgehog (SHH) Proteins
sonic hedgehog (Shh) Proteins
sonic hedgehog a (shha) Proteins
sonic hedgehog L homeolog (shh.L) Proteins
sonic hedgehog (shh) Proteins
sonic hedgehog protein A (shh) Proteins
sonic hedgehog b (shhb) Proteins
9530036O11Rik Proteins
Dsh Proteins
fc83d08 Proteins
hedgehog Proteins
HHG1 Proteins
Hhg1 Proteins
HLP3 Proteins
HPE3 Proteins
Hx Proteins
Hxl3 Proteins
M100081 Proteins
MCOPCB5 Proteins
shh Proteins
SHH Proteins
SMMCI Proteins
syu Proteins
TPT Proteins
TPTPS Proteins
twh Proteins
twhh Proteins
vhh-1 Proteins
vhh1 Proteins
wu:fc83d08 Proteins
Xhh Proteins
xshh Proteins
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