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Human SSBP1 Protein expressed in Escherichia coli (E. coli) - ABIN1098578
Müller-Höcker, Schäfer, Li: Immunocytochemical localization of mitochondrial single-stranded DNA-binding protein in mitochondria-rich cells of normal and neoplastic human tissue. in Applied immunohistochemistry & molecular morphology : AIMM / official publication of the Society for Applied Immunohistochemistry 2001
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SSBp1 deletion results in increased chromosomal aberrations and localizes to telomeres and participate in the repair of uncapped telomeres.
overexpression of Mitogenin I (show POLDIP2 Proteins) or mitochondrial single-stranded DNA-binding protein (show RPA1 Proteins) increased elongated or fragmented mitochondria in mouse C2C12 myoblast cells, respectively.
The stimulatory effect of mtSSB on Pol gamma (show POLG Proteins) on these ssDNA templates is not species-specific.
This study determined that hSSB1 acetylation at K94 mediated by the acetyltransferase p300 and the deacetylases SIRT4 and HDAC10 impaired its ubiquitin-mediated degradation by proteasomes.
SSBP1 protects cells from proteotoxic stresses by potentiating stress-induced HSF1 (show HSF1 Proteins) transcriptional activity
Fbxl5 (show FBXL5 Proteins) interacts with and targets hSSB1 for ubiquitination and degradation, which could be prevented by ATM (show ATM Proteins)-mediated hSSB1 T117 phosphorylation.
In response to the DNA damage response, INTS3 (show INTS3 Proteins)-hSSB1-INTS6 (show INTS6 Proteins) complex relocates to the DNA damage sites.
Results indicate that hSSB1 may regulate DNA damage checkpoints by positively modulating p53 (show TP53 Proteins) and its downstream target p21 (show CDKN1A Proteins).
mtSSB potentially prevents formation of DNA breaks in ssDNA, ensuring that base removal primarily occurs in dsDNA.
Local enrichment of UNG1 (show UNG Proteins) at DNA-bound mtSSB may furthermore facilitate rapid access to- and processing of the damage once the dsDNA conformation is restored.
mtSSB uses distinct structural elements to interact functionally with its mtDNA replisome partners and to promote proper mtDNA replication in animal cells
hSSB1 may positively modulate p21 (show CDKN1A Proteins) to regulate cell cycle progression and DNA damage response, implicating hSSB1 as a novel, promising therapeutic target for cancers such as hepatocellular carcinoma
SSBP1 is a housekeeping gene involved in mitochondrial biogenesis (Tiranti et al., 1995
, single-stranded DNA-binding protein, mitochondrial
, PWP1-interacting protein 17
, single strand DNA-binding protein P16
, single-stranded DNA binding