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Human TTC5, a novel tetratricopeptide repeat domain containing gene, activates p53 (show TP53 Proteins) and inhibits AP-1 (show FOSB Proteins) pathway.
TTC5 and EP300 (show EP300 Proteins) cooperate to prevent excessive accumulation of MYC (show MYC Proteins) in AML (show RUNX1 Proteins) cells and their sensitization to cell death.
TTC5 is a novel cofactor regulating GR function in a stress-dependent manner.
Adapter protein involved in p53/TP53 response that acts by regulating and mediating the assembly of multi-protein complexes. Required to facilitate the interaction between JMY and p300/EP300 and increase p53/TP53-dependent transcription and apoptosis. Prevents p53/TP53 degradation by MDM2 (By similarity).
tetratricopeptide repeat domain 5
, tetratricopeptide repeat protein 5
, tetratricopeptide repeat protein 5-like
, TPR repeat protein 5
, stress-responsive activator of p300