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Browse our anti-WAPAL (WAPAL) Antibodies

Full name:
anti-Wings Apart-Like Protein Homolog Antibodies (WAPAL)
On www.antibodies-online.com are 26 Wings Apart-Like Protein Homolog (WAPAL) Antibodies from 10 different suppliers available. Additionally we are shipping and many more products for this protein. A total of 32 WAPAL products are currently listed.
Synonyms:
2410073G16, A530089A20Rik, BC037674, FOE, KIAA0261, mKIAA0261, mWAPL, RGD1308960, WAPL
list all antibodies Gene Name GeneID UniProt
WAPAL 290577  
WAPAL 23063 Q7Z5K2
WAPAL 218914 Q65Z40

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Most Popular Reactivities for anti-WAPAL (WAPAL) Antibodies

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anti-Rat (Rattus) WAPAL Antibodies:

anti-Human WAPAL Antibodies:

anti-Mouse (Murine) WAPAL Antibodies:

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Top referenced anti-WAPAL Antibodies

  1. Human Polyclonal WAPAL Primary Antibody for ICC, IF - ABIN4365920 : Lu, Cui, Fu, Wang: Human wings apart-like gene is specifically overexpressed in cervical cancer. in Oncology letters 2016 (PubMed)

More Antibodies against WAPAL Interaction Partners

Human Wings Apart-Like Protein Homolog (WAPAL) interaction partners

  1. WAPL-depleted cells undergo anaphase with segregation errors, resulting in micronuclei and DNA damage. Stable WAPL depletion arrests cells in a p53 (show TP53 Antibodies)-dependent manner but causes p53 (show TP53 Antibodies)-deficient cells to become highly aneuploid.

  2. Wapl-C interacts with other cohesin subunits and possibly unknown effectors to trigger cohesin release from chromatin

  3. Depletion of Wapl, a negative cohesin regulator, rescues sister chromatid homologous recombination defects of Mms21 (show NSMCE2 Antibodies)-deficient or Scc1 (show PTPRJ Antibodies) mutant-expressing cells

  4. FOE encodes a protein of 1227 amino acids with a functional bipartite nuclear localization signal, an arginine-rich motif, a putative nuclear export signal as well as with three highly acidic regions and a predicted coiled-coil domain.

  5. Wapl is a new regulator of sister chromatid resolution and promotes release of cohesin from chromosomes by directly interacting with its regulatory subunits

  6. Wapl is required to unlock cohesin from a particular state in which it is stably bound to chromatin.

  7. our study suggests that unscheduled overexpression of WAPL disturbs mitosis and cytokinesis, and contributes to tumor progression by induction of chromosomal instability.

  8. isolated a large number of additional alternatively spliced WAPL variants from various cervical epithelia. Each variant consists of a variable 5'-terminal region and the conserved remainder.

Mouse (Murine) Wings Apart-Like Protein Homolog (WAPAL) interaction partners

  1. High levels of WAPAL are observed in human cervical cancers, and expression of human WAPAL in mice causes tumor formation.

  2. in mitosis, Wapl-mediated release of cohesin from DNA is essential for proper chromosome segregation and protects cohesin from cleavage by the protease separase, thus enabling mitotic exit in the presence of functional cohesin complexes

  3. mWAPL may be involved in spermatogenesis and be target genes mediating the reproductive toxicity induced by 2,3,7,8-trachlorodibenzo-p-dioxin .

WAPAL Antigen Profile

Antigen Summary

Regulator of sister chromatid cohesion in mitosis which negatively regulates cohesin association with chromatin. Involved in both sister chromatid cohesion during interphase and sister- chromatid resolution during early stages of mitosis. Couples DNA replication to sister chromatid cohesion. Cohesion ensures that chromosome partitioning is accurate in both meiotic and mitotic cells and plays an important role in DNA repair (By similarity).

Alternative names and synonyms associated with WAPAL

  • wings apart-like homolog (Drosophila) (Wapal) antibody
  • wings apart-like homolog (Drosophila) (WAPAL) antibody
  • wings apart-like protein homolog (LOC100408201) antibody
  • wings apart-like protein homolog (LOC100475548) antibody
  • wings apart-like homolog (Drosophila) (wapal) antibody
  • wings apart-like protein homolog (LOC100581674) antibody
  • 2410073G16 antibody
  • A530089A20Rik antibody
  • BC037674 antibody
  • FOE antibody
  • KIAA0261 antibody
  • mKIAA0261 antibody
  • mWAPL antibody
  • RGD1308960 antibody
  • WAPL antibody

Protein level used designations for WAPAL

wings apart-like protein homolog , wings apart-like homolog (Drosophila) , WAPL family member (wapl-1)-like , friend of EBNA2 (Epstein-Barr virus nuclear protein 2) , friend of EBNA2 protein , DIF-2 , WAPL protein , dioxin-inducible factor 2 , friend of EBNA2

GENE ID SPECIES
290577 Rattus norvegicus
423608 Gallus gallus
534322 Bos taurus
100408201 Callithrix jacchus
100452617 Pongo abelii
100475548 Ailuropoda melanoleuca
100546200 Meleagris gallopavo
100553268 Anolis carolinensis
100581674 Nomascus leucogenys
23063 Homo sapiens
218914 Mus musculus
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