Browse our C4A Proteins (C4A)

Full name:
Complement Fragment 4a Proteins (C4A)
On www.antibodies-online.com are 11 Complement Fragment 4a (C4A) Proteins from 4 different suppliers available. Additionally we are shipping C4A Kits (48) and C4A Antibodies (34) and many more products for this protein. A total of 94 C4A products are currently listed.
Synonyms:
C4, C4-1, C4A2, C4A3, C4A4, C4A6, C4AD, C4b, C4S, CO4, CPAMD2, RG, Slp
list all proteins Gene Name GeneID UniProt
C4A 720 P0C0L4
C4A 625018  
C4A 24233 P08649

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Human Complement Fragment 4a (C4A) interaction partners

  1. This study shows that the C4c/C4 ratio seems to be a better diagnostic measure than total antigenic C4 alone. Our findings underline that screening with total antigenic C4 implies a risk of overlooking C1-INH-HAE patients.

  2. In comparison with C4-intact patients, C4-deficient patients had a different clinical/serologic lupus-like phenotype and lacked the lupus interferon (show IFNA Proteins) signature.

  3. C4 copy number variations and deficiency of C4A (show C4B Proteins) both play an important role in the risk and manifestations of systemic lupus erythematosus in East Asian and European populations

  4. Complement C4A deficiency (gene copy number <=1) was identified as a risk factor in a case-control study of juvenile dermatomyositis, particularly when subjects concurrently carried the HLA-DRB1 (show HLA-DRB1 Proteins)*0301 allele.

  5. Solution Structures of Complement C2 and Its C4 Complexes Propose Pathway-specific Mechanisms for Control and Activation of the Complement Proconvertases.

  6. Coronary atherosclerosis is distinguished by serum C4 complement up-regulation and ceruloplasmin (show CP Proteins) down-regulation.

  7. find strong statistical significance for association of increased copy number of C4A (show C4B Proteins) (OR 0.81 (0.73; 0.89);P = 4.4 x 10(-5)), with the effect most pronounced in individuals over 78 years (OR 0.67 (0.55; 0.81)) and females

  8. genetic polymorphism is associated with acute graft versus host disease in unrelated hematopoietic stem cell transplantation

  9. C4A (show C4B Proteins) and C4B (show C4B Proteins) gene copy numbers are stronger risk factors for juvenile-onset than for adult-onset systemic lupus erythematosus.

  10. C4 levels were significantly lower in Factor XII (show F12 Proteins)-hereditary angioedema than in idiopathic non-histaminergic acquired angioedema.

Mouse (Murine) Complement Fragment 4a (C4A) interaction partners

C4A Protein Profile

Protein Summary

This gene encodes the acidic form of complement factor 4, part of the classical activation pathway. The protein is expressed as a single chain precursor which is proteolytically cleaved into a trimer of alpha, beta, and gamma chains prior to secretion. The trimer provides a surface for interaction between the antigen-antibody complex and other complement components. The alpha chain may be cleaved to release C4 anaphylatoxin, a mediator of local inflammation. Deficiency of this protein is associated with systemic lupus erythematosus and type I diabetes mellitus. This gene localizes to the major histocompatibility complex (MHC) class III region on chromosome 6. Varying haplotypes of this gene cluster exist, such that individuals may have 1, 2, or 3 copies of this gene. Two transcript variants encoding different isoforms have been found for this gene.

Alternative names and synonyms associated with C4A

  • complement component 4A (Rodgers blood group) (C4A)
  • complement component 4A (Rodgers blood group) (C4a)
  • C4 protein
  • C4-1 protein
  • C4A2 protein
  • C4A3 protein
  • C4A4 protein
  • C4A6 protein
  • C4AD protein
  • C4b protein
  • C4S protein
  • CO4 protein
  • CPAMD2 protein
  • RG protein
  • Slp protein

Protein level used designations for Complement Fragment 4a Proteins (C4A)

C3 and PZP-like alpha-2-macroglobulin domain-containing protein 2 , C4A anaphylatoxin , Rodgers form of C4 , acidic C4 , acidic complement C4 , complement C4-A , sex-limited protein , complement C4 , complement component 4 (within H-2S) , complement component 4, gene 1 , complement component 4B (Chido blood group) , complement component 4B (Childo blood group)

GENE ID SPECIES
720 Homo sapiens
100356976 Oryctolagus cuniculus
625018 Mus musculus
24233 Rattus norvegicus
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