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Browse our C4A Proteins (C4A)

Full name:
Complement Fragment 4a Proteins (C4A)
On are 10 Complement Fragment 4a (C4A) Proteins from 4 different suppliers available. Additionally we are shipping C4A Kits (47) and C4A Antibodies (18) and many more products for this protein. A total of 76 C4A products are currently listed.
C4, C4-1, C4A2, C4A3, C4A4, C4A6, C4AD, C4b, C4S, CO4, CPAMD2, RG, Slp
list all proteins Gene Name GeneID UniProt
C4A 720 P0C0L4
Mouse C4A C4A 625018  
C4A 24233 P08649

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C4A Proteins (C4A) by Origin

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Human Complement Fragment 4a (C4A) interaction partners

  1. C4A (show C4B Proteins) and C4B (show C4B Proteins) gene copy numbers are stronger risk factors for juvenile-onset than for adult-onset systemic lupus erythematosus.

  2. Complement C4A deficiency (gene copy number <=1) was identified as a risk factor in a case-control study of juvenile dermatomyositis, particularly when subjects concurrently carried the HLA-DRB1 (show HLA-DRB1 Proteins)*0301 allele.

  3. C4 levels were significantly lower in Factor XII (show F12 Proteins)-hereditary angioedema than in idiopathic non-histaminergic acquired angioedema.

  4. our study indicates that Finnish NTM (show NTM Proteins) patients had significantly more often C4 deficiencies than the healthy control subjects.

  5. Complement components C3a (show C3 Proteins) and C4a (show C4B Proteins), but not C5a, display antimicrobial activity against P. aeruginosa, E. coli, B. subtilis, and C. albicans.

  6. C4 is a novel cellular substrate of the HCV NS3/4A protease.

  7. serum C4a desArg is a potential biomarker for the severity of histological findings in patients with IgA nephropathy.

  8. Our findings indicate that a high copy number of C4A (show C4B Proteins) confers risk for Behcet disease by modulating the expression of C4A (show C4B Proteins) and enhancing IL-6 (show IL6 Proteins) production.

  9. Studies indicate that initiation of lectin compleme pathway leads to activation of the serine proteases MASP-1 (show MASP1 Proteins) and MASP-2 (show MASP2 Proteins) resulting in deposition of C4 on the activator and assembly of the C3 convertase.

  10. A molecular switch governs the interaction between the human complement protease C1s and its substrate, complement C4.

Mouse (Murine) Complement Fragment 4a (C4A) interaction partners

C4A Protein Profile

Protein Summary

This gene encodes the acidic form of complement factor 4, part of the classical activation pathway. The protein is expressed as a single chain precursor which is proteolytically cleaved into a trimer of alpha, beta, and gamma chains prior to secretion. The trimer provides a surface for interaction between the antigen-antibody complex and other complement components. The alpha chain may be cleaved to release C4 anaphylatoxin, a mediator of local inflammation. Deficiency of this protein is associated with systemic lupus erythematosus and type I diabetes mellitus. This gene localizes to the major histocompatibility complex (MHC) class III region on chromosome 6. Varying haplotypes of this gene cluster exist, such that individuals may have 1, 2, or 3 copies of this gene. Two transcript variants encoding different isoforms have been found for this gene.

Alternative names and synonyms associated with C4A

  • complement component 4A (Rodgers blood group) (C4A)
  • complement component 4A (Rodgers blood group) (C4a)
  • C4 protein
  • C4-1 protein
  • C4A2 protein
  • C4A3 protein
  • C4A4 protein
  • C4A6 protein
  • C4AD protein
  • C4b protein
  • C4S protein
  • CO4 protein
  • CPAMD2 protein
  • RG protein
  • Slp protein

Protein level used designations for Complement Fragment 4a Proteins (C4A)

C3 and PZP-like alpha-2-macroglobulin domain-containing protein 2 , C4A anaphylatoxin , Rodgers form of C4 , acidic C4 , acidic complement C4 , complement C4-A , sex-limited protein , complement C4 , complement component 4 (within H-2S) , complement component 4, gene 1 , complement component 4B (Chido blood group) , complement component 4B (Childo blood group)

720 Homo sapiens
100356976 Oryctolagus cuniculus
625018 Mus musculus
24233 Rattus norvegicus
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