C4A Products
(Complement Fragment C4a (C4a))
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This gene encodes the acidic form of complement factor 4, part of the classical activation pathway. The protein is expressed as a single chain precursor which is proteolytically cleaved into a trimer of alpha, beta, and gamma chains prior to secretion. The trimer provides a surface for interaction between the antigen-antibody complex and other complement components. The alpha chain may be cleaved to release C4 anaphylatoxin, a mediator of local inflammation. Deficiency of this protein is associated with systemic lupus erythematosus and type I diabetes mellitus. This gene localizes to the major histocompatibility complex (MHC) class III region on chromosome 6. Varying haplotypes of this gene cluster exist, such that individuals may have 1, 2, or 3 copies of this gene. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011].
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Featured C4A Categories
C4A Antibodies
High quality antibodies with extensive validation data.
C4A ELISA Kits
Reliable ELISA kits for a wide range of species.
C4A Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended C4A Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
IHC, ELISA, Coat, StM
Validations
- (4)
Cat. No.
ABIN6940808
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Application
WB, IHC, IP, ICC
Validations
- (3)
Cat. No.
ABIN7440377
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Mouse
Application
WB, IHC, IP, ICC
Validations
- (2)
Cat. No.
ABIN7431716
Quantity
100 μL
Datasheet
Datasheet
Recommended C4A ELISA Kits
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (6)
- (1)
Cat. No.
ABIN6955046
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Rat
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6966053
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6966051
Quantity
96 tests
Datasheet
Datasheet
Recommended C4A Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1347536
Quantity
2 μg
Datasheet
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
- (1)
Cat. No.
ABIN7122475
Quantity
50 μg
Datasheet
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
- (1)
Cat. No.
ABIN3091778
Quantity
1 mg
Datasheet
Datasheet
Latest Publications for our C4A products
: "Maternal immune activation results in complex microglial transcriptome signature in the adult offspring that is reversed by minocycline treatment." in: Translational psychiatry, Vol. 7, Issue 5, pp. e1120, (2018) (PubMed).: "Quantitative analysis of hydroxyapatite-binding plasma proteins in genotyped individuals with late-stage age-related macular degeneration." in: Experimental eye research, Vol. 172, pp. 21-29, (2018) (PubMed).
: "Mechanisms of basin-scale nitrogen load reductions under intensified irrigated agriculture." in: PLoS ONE, Vol. 10, Issue 3, pp. e0120015, (2015) (PubMed).
: "Novel Photoresponsive Linear, Graft, and Comb-Like Copolymers with Azobenzene Chromophores in the Main-Chain and/or Side-Chain: Facile One-Pot Synthesis and Photoresponse Properties." in: Macromolecular rapid communications, Vol. 36, Issue 17, pp. 1578-84, (2015) (PubMed).
: "Identification of altered plasma proteins by proteomic study in valvular heart diseases and the potential clinical significance." in: PLoS ONE, Vol. 8, Issue 8, pp. e72111, (2013) (PubMed).
: "Circulation levels of acute phase proteins in patients with Takayasu arteritis." in: Journal of vascular surgery, Vol. 51, Issue 3, pp. 700-6, (2010) (PubMed).
: "Alternative complement activity in the egg cytosol of amphioxus Branchiostoma belcheri: evidence for the defense role of maternal complement components." in: PLoS ONE, Vol. 4, Issue 1, pp. e4234, (2009) (PubMed).
: "Complement activity in the egg cytosol of zebrafish Danio rerio: evidence for the defense role of maternal complement components." in: PLoS ONE, Vol. 3, Issue 1, pp. e1463, (2008) (PubMed).
: "Plasma C3a and C4a levels in liver transplant recipients: a longitudinal study." in: Immunopharmacology, Vol. 46, Issue 2, pp. 163-74, (2000) (PubMed).
: "Possible mechanism for in vitro complement activation in blood and plasma samples: futhan/EDTA controls in vitro complement activation." in: Clinical chemistry, Vol. 45, Issue 8 Pt 1, pp. 1190-9, (1999) (PubMed).
Synonyms and alternative names related to C4A
complement C4A (Rodgers blood group) (C4A), complement component 4A (Rodgers blood group) (C4a), C4, C4-1, C4A2, C4A3, C4A4, C4A6, C4AD, C4b, C4S, CO4, CPAMD2, RG, SlpProtein level used designations for C4A
- C3 and PZP-like alpha-2-macroglobulin domain-containing protein 2
- C4A anaphylatoxin
- Rodgers form of C4
- acidic C4
- acidic complement C4
- complement C4-A
- sex-limited protein
- complement C4
- complement component 4 (within H-2S)
- complement component 4, gene 1
- complement component 4B (Chido blood group)
- complement component 4B (Childo blood group)
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