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Advanced pathologic stage was associated with significantly higher expression of KLK15 and PCA3 mRNAs.
KLK15 mRNA expression levels are a novel marker for the differential diagnosis of prostate cancer.
These findings suggest a role for KLK15 genetic variation in the etiology of prostate cancer among men of European ancestry.
Multivariate analysis identified dichotomised KLK15 expression, corrected for patient parameters age, preoperative prostate-specific antigen (show KLK3 Proteins) level, pathological tumour stage, Gleason score and surgical margins, as an prognostic factor for poor outcome.
KLK15 expression analysis could be employed as a valuable tool for the discrimination between benign prostatic hyperplasia and prostate cancer tissue specimens and as an unfavorable prognostic marker for prostate cancer.
Data show six non-synonymous amino acid or frame shift changes in the KLK3 (show KLKB1 Proteins) gene and three changes in each of the neighboring genes, KLK15 and KLK2 (show KLK2 Proteins).
Kallikrein 15 expression is an independent prognostic factors of progression-free and overall survival in breast cancer patients
KLK15 expression, as assessed by quantitative RT-PCR, is an independent marker of unfavorable prognosis for ovarian cancer.
Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. In prostate cancer, this gene has increased expression, which indicates its possible use as a diagnostic or prognostic marker for prostate cancer. The gene contains multiple polyadenylation sites and alternative splicing results in multiple transcript variants encoding distinct isoforms.
, ACO protease
, kallikrein-like serine protease