Browse our Kallikrein 4 Proteins (KLK4)

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Kallikrein-Related Peptidase 4 Proteins (KLK4)
On are 28 Kallikrein-Related Peptidase 4 (KLK4) Proteins from 13 different suppliers available. Additionally we are shipping Kallikrein 4 Antibodies (75) and Kallikrein 4 Kits (9) and many more products for this protein. A total of 116 Kallikrein 4 products are currently listed.
AI2A1, ARM1, EMSP, Emsp1, ESMP1, kallikrein, KLK-L1, PRSS17, PSTS
list all proteins Gene Name GeneID UniProt
KLK4 56640  
KLK4 9622 Q9Y5K2
KLK4 408210  

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Kallikrein 4 Proteins (KLK4) by Origin

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Top referenced Kallikrein 4 Proteins

  1. Human Kallikrein 4 Protein expressed in HEK-293 Cells - ABIN2181438 : Hu, Zhang, Sun, Yang, Cao, Ryu, Simmer: Characterization of the mouse and human PRSS17 genes, their relationship to other serine proteases, and the expression of PRSS17 in developing mouse incisors. in Gene 2000 (PubMed)
    Show all 4 references for 2181438

  2. Human Kallikrein 4 Protein expressed in Human Cells - ABIN2004853 : Yousef, Obiezu, Luo, Black, Diamandis: Prostase/KLK-L1 is a new member of the human kallikrein gene family, is expressed in prostate and breast tissues, and is hormonally regulated. in Cancer research 1999 (PubMed)
    Show all 2 references for 2004853

More Proteins for Kallikrein 4 Interaction Partners

Mouse (Murine) Kallikrein-Related Peptidase 4 (KLK4) interaction partners

  1. normal enamel maturation is regulated by TGF-ss signaling through the expression of KLK4

  2. The breakage of enamel near the dentino-enamel junction in Klk4-null mice is not due to a failure of odontoblasts to express Klk4, but it relates to a progressive hypomineralization of enamel with depth.

  3. Effect of kallikrein 4 loss on enamel mineralization: comparison with mice lacking matrix metalloproteinase 20 (show MMP20 Proteins).

  4. expression of KLK4 correlates with the stage-associated changes in the digestion of enamel proteins

  5. Mice lacking expression of the AmelX (show AMELX Proteins), Enam (show ENAM Proteins) and Mmp20 (show MMP20 Proteins) genes have been generated.

  6. Dipeptidyl peptidase I (show CTSC Proteins) activates pro-KLK4 to cleave a fluorogenic peptide containing a KLK4 cleavage site in mice incisor enamel organs during amelogenesis. site.

  7. Klk4 is essential for the removal of enamel proteins and the proper maturation of enamel crystals in mice

Human Kallikrein-Related Peptidase 4 (KLK4) interaction partners

  1. The KLK4 protein is localized in the cytoplasm of tumor and stroma cells.

  2. KLK4 as a potential multifunctional regulator of prostate cancer progression.

  3. Low KLK4 expression is associated with lupus nephritis.

  4. KLK4 may contribute to the metastasis of OSCC through the PI3 K (show PIK3CA Proteins)/AKT (show AKT1 Proteins) signaling pathway

  5. KLK4 acts as an oncogene (show RAB1A Proteins) in OSCC cells, and targeting KLK4 may be a promising method for OSCC therapy.

  6. Studied a 70-kb region surrounding KLK4 in East Asian population; found within combined unusual low levels of diversity, high frequency variants with significant levels of population differentiation.

  7. Novel homozygous mutations in the KLK4 (c.620_621delCT, p.Ser207Trpfs*38) were identified in amelogenesis imperfecta consanguinity. Mutant KLK4 was degraded intracellularly and became inactive.

  8. this study provides supportive evidence in favor of a prognostic value for KLK4 in OSCC and suggests that KLK4 could serve as a potential therapeutic target in patients with oral cancer.

  9. Human ephrin-B2 (show EFNB2 Proteins) is poorly cleaved by KLK4 while the homologous mouse is not.

  10. miR (show MLXIP Proteins)-378 was predicted to target both KLK2 (show KLK2 Proteins) and KLK4 and downregulated levels detected in prostate cancer patients.

Kallikrein 4 (KLK4) Protein Profile

Protein Summary

Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. In some tissues its expression is hormonally regulated. The expression pattern of a similar mouse protein in murine developing teeth supports a role for the protein in the degradation of enamel proteins. Alternate splice variants for this gene have been described, but their biological validity has not been determined.

Alternative names and synonyms associated with Kallikrein 4 (KLK4)

  • kallikrein related-peptidase 4 (prostase, enamel matrix, prostate) (Klk4)
  • kallikrein-related peptidase 4 (KLK4)
  • kallikrein-related peptidase 4 (Klk4)
  • AI2A1 protein
  • ARM1 protein
  • EMSP protein
  • Emsp1 protein
  • ESMP1 protein
  • kallikrein protein
  • KLK-L1 protein
  • PRSS17 protein
  • PSTS protein

Protein level used designations for KLK4

kallikrein 4 (prostase, enamel matrix, prostate) , kallikrein-4 , protease, serine 17 (enamel matrix, prostate) , androgen-regulated message 1 , enamel matrix serine protease 1 , enamel matrix serine proteinase 1 , kallikrein-like protein 1 , prostase , serine protease 17 , Enamel matrix serine proteinase 1

56640 Mus musculus
9622 Homo sapiens
408210 Rattus norvegicus
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