Browse our anti-Integrin alpha 2 (ITGA2) Antibodies

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anti-Integrin alpha 2 Antibodies (ITGA2)
On www.antibodies-online.com are 491 Integrin alpha 2 (ITGA2) Antibodies from 26 different suppliers available. Additionally we are shipping Integrin alpha 2 Kits (13) and Integrin alpha 2 Proteins (10) and many more products for this protein. A total of 519 Integrin alpha 2 products are currently listed.
Synonyms:
BR, CD49B, DX5, gpi, GPIa, HPA-5, PGI, pgi-1, VLA-2, VLAA2, wu:fc02c05, zgc:86919
list all antibodies Gene Name GeneID UniProt
ITGA2 16398 Q62469
ITGA2 170921  
ITGA2 3673 P17301

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Top referenced anti-Integrin alpha 2 Antibodies

  1. Human Monoclonal ITGA2 Primary Antibody for IF, WB - ABIN968317 : Emsley, King, Bergelson, Liddington: Crystal structure of the I domain from integrin alpha2beta1. in The Journal of biological chemistry 1997 (PubMed)
    Show all 5 references for 968317

  2. Human Monoclonal ITGA2 Primary Antibody for FACS - ABIN118701 : Favaloro, Moraitis, Bradstock, Koutts: Co-expression of haemopoietic antigens on vascular endothelial cells: a detailed phenotypic analysis. in British journal of haematology 1990 (PubMed)
    Show all 5 references for 118701

  3. Human Monoclonal ITGA2 Primary Antibody for FACS, IHC (fro) - ABIN319765 : Yoshino, Ami, Terao, Tashiro, Honda: Upgrading of flow cytometric analysis for absolute counts, cytokines and other antigenic molecules of cynomolgus monkeys (Macaca fascicularis) by using anti-human cross-reactive antibodies. in Experimental animals / Japanese Association for Laboratory Animal Science 2000 (PubMed)
    Show all 4 references for 319765

  4. Human Monoclonal ITGA2 Primary Antibody for FACS - ABIN118700 : Ciarlet, Crawford, Cheng, Blutt, Rice, Bergelson, Estes: VLA-2 (alpha2beta1) integrin promotes rotavirus entry into cells but is not necessary for rotavirus attachment. in Journal of virology 2002 (PubMed)
    Show all 3 references for 118700

  5. Human Monoclonal ITGA2 Primary Antibody for EIA, FACS - ABIN319775 : Fitter, Sincock, Jolliffe, Ashman: Transmembrane 4 superfamily protein CD151 (PETA-3) associates with beta 1 and alpha IIb beta 3 integrins in haemopoietic cell lines and modulates cell-cell adhesion. in The Biochemical journal 1999 (PubMed)
    Show all 2 references for 319775

  6. Human Monoclonal ITGA2 Primary Antibody for FACS - ABIN118698 : Mazurov, Vinogradov, Kabaeva, Antonova, Romanov, Vlasik, Antonov, Smirnov: A monoclonal antibody, VM64, reacts with a 130 kDa glycoprotein common to platelets and endothelial cells: heterogeneity in antibody binding to human aortic endothelial cells. in Thrombosis and haemostasis 1992 (PubMed)
    Show all 2 references for 118698

  7. Human Polyclonal ITGA2 Primary Antibody for EIA, WB - ABIN951336 : Jokinen, White, Salmela, Huhtala, Käpylä, Sipilä, Puranen, Nissinen, Kankaanpää, Marjomäki, Hyypiä, Johnson, Heino: Molecular mechanism of alpha2beta1 integrin interaction with human echovirus 1. in The EMBO journal 2010 (PubMed)
    Show all 2 references for 951336

  8. Human Monoclonal ITGA2 Primary Antibody for EIA, FACS - ABIN118720 : Sincock, Fitter, Parton, Berndt, Gamble, Ashman et al.: PETA-3/CD151, a member of the transmembrane 4 superfamily, is localised to the plasma membrane and endocytic system of endothelial cells, associates with multiple integrins and modulates cell ... in Journal of cell science 1999 (PubMed)
    Show all 2 references for 118720

  9. Mouse (Murine) Monoclonal ITGA2 Primary Antibody for FACS - ABIN4897023 : Siegemund, Schütze, Schulz, Wolk, Nasilowska, Straubinger, Sabat, Alber: Differential IL-23 requirement for IL-22 and IL-17A production during innate immunity against Salmonella enterica serovar Enteritidis. in International immunology 2009 (PubMed)

More Antibodies against Integrin alpha 2 Interaction Partners

Zebrafish Integrin alpha 2 (ITGA2) interaction partners

  1. The differential expression of gpia and gpib in zebrafish suggests partition or divergence of gpi functions between the two duplicates.

  2. Comparison of glucose phosphase isomerase (GPI) genes from several vertebrates suggests that GPIs are being subjected to purifying selection to maintain the polarity and volume of the protein, but not its charge.

Mouse (Murine) Integrin alpha 2 (ITGA2) interaction partners

  1. low expression of alpha2beta1 integrin increased protein kinase B (AKT (show AKT1 Antibodies)) activation and alpha-smooth muscle actin (show ACTG2 Antibodies) (alpha-SMA (show SMN1 Antibodies)) expression. This occurred due to the instability of phosphatase and tensin homolog (PTEN (show PTEN Antibodies)) in myofibroblasts on fibrillar collagen.

  2. Ceacam1 (show CEACAM1 Antibodies) is essential for normal integrin aIIbb3-mediated platelet function; the disruption of mouse Ceacam1 (show CEACAM1 Antibodies) induced moderate integrin aIIbb3-mediated functional defects.

  3. HRG (show HRG Antibodies) binds to alpha2 integrin through low-affinity interactions in a heparin sulfate-independent manner, thereby blocking endothelial cells adhesion to collagen I.

  4. LG3, through interactions with alpha2beta1 integrins on recipient-derived cells leading to activation of ERK1/2 (show MAPK1/3 Antibodies) and increased migration, favors myointimal thickening

  5. IFN-gamma (show IFNG Antibodies) induces aberrant CD49b+ NK cell recruitment and pregnancy failure through regulating CX3CL1 (show CX3CL1 Antibodies).

  6. alphaIIbbeta3 regulates Syk (show SYK Antibodies) through an ITAM-independent pathway in mice and provide novel insight into the course of events underlying Syk (show SYK Antibodies) activation and hemITAM phosphorylation by CLEC-2 (show CLEC1B Antibodies)

  7. the collagen receptors DDR1 (show DDR1 Antibodies) and integrin a2b1 contribute to regulate GBM-maturation and to control matrix accumulation.

  8. alpha2beta1 integrin contributes to the pathogenesis of retinopathy. We describe a newly identified role for alpha2beta1 integrin in mediating hypoxia-induced Muller cell VEGF-A (show VEGFA Antibodies) production.

  9. required for the migration of memory CD4 (show CD4 Antibodies) T-cell precursors into their survival niches of the bone marrow

  10. alpha2beta1 integrin is expressed on synovial Th17 cells from CIA (show NCOA5 Antibodies) mice. Its neutralization reduced inflammation, cartilage degradation, bone erosion, RANKL (show TNFSF11 Antibodies) & IL-17 (show IL17A Antibodies) levels, & the numbers of osteoclasts and TH17 cells.

Human Integrin alpha 2 (ITGA2) interaction partners

  1. Meta-analysis found that glycoprotein Ia (show MMRN1 Antibodies) C807T T allele or the TT genotype, the Ser (show SIGLEC1 Antibodies)-allele of HPA-3 and B allele of glycoprotein Ibalpha (show GP1BA Antibodies) variable number tandem repeat polymorphisms were associated with increased risk for ischemic stroke.

  2. Data indicate no association of maternal or fetal ITGA2 C807T SNP, ITGB3 (show ITGB3 Antibodies) T1565C SNP, PECAM1 (show PECAM1 Antibodies) CTG - GTG (show GGT1 Antibodies) and SELP (show SEPP1 Antibodies) A/C polymorphisms with fetal growth restriction (FGR (show FGR Antibodies)).

  3. The most common HPA (show HPSE Antibodies) genotypes among Saudis were HPA-1 (show HPSE Antibodies) a + b- (75%), HPA-2 (show HPSE2 Antibodies) a + b- (62%), HPA-3 a + b- (51.5%), HPA (show HPSE Antibodies)-4 a + b- (99%), HPA-5 a + b- (76.5%), HPA (show HPSE Antibodies)-6 a + b- (100%) and HPA (show HPSE Antibodies)-15 a + b + (50%). The prevalent allele among the HPA (show HPSE Antibodies) systems was (a), except in the HPA (show HPSE Antibodies)-15 system where the (b) allele was found in 52% of the subjects.

  4. high miR (show MLXIP Antibodies)-128 expression suppressed osteosarcoma cell migration, invasion, and EMT (show ITK Antibodies) development through targeting ITGA2, which may be recommended as a therapeutic target for osteosarcoma.

  5. Study identified a novel RANKL (show TNFSF11 Antibodies) function in the promotion of cell adhesion to type I collagen through the RANKL (show TNFSF11 Antibodies)-NF-kappa B (show NFKB1 Antibodies)-integrin alpha 2 pathway and found integrin alpha2 and RANKL (show TNFSF11 Antibodies) up-regulated in non small cell lung carcinoma.

  6. High ITGA2 expression is associated with cervical cancer.

  7. PDI-mediated disulfide bond exchange plays a pivotal role in the post-ligation phase of alphaIIbbeta3-mediated adhesion to fibrinogen, while this step in alphavbeta3-mediated adhesion is independent of disulfide exchange

  8. Our results indicate that GpIa-807T and GpIIIa (show ITGB3 Antibodies)-PlA2 (show YWHAZ Antibodies) may be susceptibility alleles for in vitro fertilization implantation failure.

  9. PFL-mediated downregulation of integrin and EGFR contributes to the inhibition of tumor growth in vitro and in vivo. This novel anti-cancer mechanism of PFL suggests that this lectin would be useful as an anti-cancer drug or an adjuvant for other drugs.

  10. HRG (show NRG1 Antibodies) binds to alpha2 integrin through low-affinity interactions in a heparin sulfate-independent manner, thereby blocking endothelial cells adhesion to collagen I.

Cow (Bovine) Integrin alpha 2 (ITGA2) interaction partners

  1. Flow induced alpha2beta1 activation in cells on collagen, but not on fibronectin or fibrinogen. Conversely, alpha5beta1 and alphavbeta3 are activated on fibronectin and fibrinogen, but not collagen.

  2. both the gpIb-VWF (show VWF Antibodies) interaction and the integrin alpha(2)beta(1)-collagen interaction contribute to platelet adhesion under high shear stress; integrin alpha(II (show GSTA3 Antibodies))beta(1) makes a greater contribution to adhesion to type I collagen because less VWF (show VWF Antibodies) is bound

Integrin alpha 2 (ITGA2) Antigen Profile

Antigen Summary

This gene encodes the alpha subunit of a transmembrane receptor for collagens and related proteins. The encoded protein forms a heterodimer with a beta subunit and mediates the adhesion of platelets and other cell types to the extracellular matrix. Loss of the encoded protein is associated with bleeding disorder platelet-type 9. Antibodies against this protein are found in several immune disorders, including neonatal alloimmune thrombocytopenia. This gene is located adjacent to a related alpha subunit gene. Alternative splicing results in multiple transcript variants.

Alternative names and synonyms associated with Integrin alpha 2 (ITGA2)

  • glucose phosphate isomerase a (gpia) antibody
  • integrin alpha 2 (Itga2) antibody
  • integrin, alpha 2 (Itga2) antibody
  • integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) (ITGA2) antibody
  • BR antibody
  • CD49B antibody
  • DX5 antibody
  • gpi antibody
  • GPIa antibody
  • HPA-5 antibody
  • PGI antibody
  • pgi-1 antibody
  • VLA-2 antibody
  • VLAA2 antibody
  • wu:fc02c05 antibody
  • zgc:86919 antibody

Protein level used designations for ITGA2

pgi1 , CD49 antigen-like family member B , GPIa , VLA-2 receptor, alpha 2 subunit , VLA-2 subunit alpha , collagen receptor , integrin alpha-2 , platelet membrane glycoprotein Ia , VLA2 receptor, alpha-2 subunit , human platelet alloantigen system 5 , platelet antigen Br , platelet glycoprotein GPIa , very late activation protein 2 receptor, alpha-2 subunit , VLA-2 alpha chain

GENE ID SPECIES
246094 Danio rerio
16398 Mus musculus
170921 Rattus norvegicus
3673 Homo sapiens
281872 Bos taurus
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