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Human Polyclonal BTBD12 Primary Antibody for IP - ABIN440495
Holloway, Mohan, Balmus, Sun, Modzelewski, Borst, Freire, Weiss, Cohen: Mammalian BTBD12 (SLX4) protects against genomic instability during mammalian spermatogenesis. in PLoS genetics 2011
Show all 3 references for ABIN440495
Human Polyclonal BTBD12 Primary Antibody for ICC, IF - ABIN440496
Wan, Yin, Horvath, Sarkar, Chen, Wu, Wan, Lu, Gu, Yu, Lue, Chang, Liu, Lei: SLX4 assembles a telomere maintenance toolkit by bridging multiple endonucleases with telomeres. in Cell reports 2013
The functioning of SLX4 is dependent on its dimerization via an oligomerization motif called the BTB domain.
SLX4-SLX1 Protein-independent Down-regulation of MUS81 (show MUS81 Antibodies)-EME1 (show EME1 Antibodies) Protein by HIV-1 Viral Protein R (Vpr).
Results identified homozygous mutations in FANCA (show FANCA Antibodies) and FANCP/SLX4 genes, both located on chromosome 16, were the affected recessive FA genes in three and one family respectively. Genotyping with short tandem repeat markers and SNP arrays revealed uniparental disomy of the entire mutation-carrying chromosome 16 in all four patients.
SLX4 (FANCP) and XPF (show ERCC4 Antibodies) (FANCQ) proteins interact with each other and play a vital role in the Fanconi anemia (show PALB2 Antibodies) (FA) DNA repair pathway. Study has revealed that the global minor allele, SLX4(Y546C), is defective in this interaction.
SUMOylation and PARylation cooperate to recruit and stabilize SLX4 at DNA damage sites.
Identification and characterization of MUS81 (show MUS81 Antibodies) point mutations that abolish interaction with the SLX4 scaffold protein (show HOMER1 Antibodies).
Vpr recruits the SLX4 endonuclease complex and Vpr-induced inappropriate activation of this complex leads to cell cycle arrest at the G2 phase.
FANCP has versatile functions in genome maintenance, its mutations result in Fanconi anemia (show PALB2 Antibodies). (Review)
Data shed light on SLX4 recruitment, and they point to the existence of currently unidentified ubiquitylated ligands and E3 ligases that are crucial for ICL repair.
The interactions of SLX4 with SUMO and ubiquitin increase its affinity for factors recognizing different DNA lesions or telomeres, helping to direct the SLX4 complex in distinct functional contexts.
SLX4 is a tumor suppressor, which activates XPF (show ERCC4 Antibodies)-ERCC1 (show ERCC1 Antibodies) nuclease (show DCLRE1C Antibodies) specificity in DNA crosslink repair.
Data indicate that SLX1 and MUS81 (show MUS81 Antibodies)-EME1 (show EME1 Antibodies) nucleases act together to resolve Holliday junctions (HJs) in a manner that requires tethering to SLX4.
these data indicate that BTBD12 functions throughout gametogenesis to maintain genome stability, possibly by co-ordinating repair processes and/or by linking DNA repair events to the cell cycle via ATM (show ATM Antibodies)
mouse Slx4, a regulator of structure-specific nucleases, disruption phenocopies Fanconi anemia (show PALB2 Antibodies)
This gene encodes a structure-specific endonuclease subunit. The encoded protein contains a central BTB domain and it forms a multiprotein complex with the ERCC4(XPF)-ERCC1, MUS81-EME1, and SLX1 endonucleases, and also associates with MSH2/MSH3 mismatch repair complex, telomere binding complex TERF2(TRF2)-TERF2IP(RAP1), the protein kinase PLK1 and the uncharacterized protein C20orf94. The multiprotein complex is required for repair of specific types of DNA lesions and is critical for cellular responses to replication fork failure. The encoded protein acts as a docking platform for the assembly of multiple structure-specific endonucleases.
BTB (POZ) domain containing 12
, SLX4 structure-specific endonuclease subunit homolog
, structure-specific endonuclease subunit SLX4
, BTB/POZ domain-containing protein 12