Browse our anti-BTB (POZ) Domain Containing 12 (BTBD12) Antibodies

Full name:
anti-BTB (POZ) Domain Containing 12 Antibodies (BTBD12)
On are 28 BTB (POZ) Domain Containing 12 (BTBD12) Antibodies from 6 different suppliers available. Additionally we are shipping and many more products for this protein. A total of 32 BTB (POZ) Domain Containing 12 products are currently listed.
AI256635, AI426760, BTBD12, D16Bwg1016e, FANCP, MUS312, RGD1566009
list all antibodies Gene Name GeneID UniProt
Anti-Rat BTBD12 BTBD12 302953  
BTBD12 84464 Q8IY92
BTBD12 52864 Q6P1D7

Show all species

Show all synonyms

Most Popular Reactivities for anti-BTB (POZ) Domain Containing 12 (BTBD12) Antibodies

Select your species and application

anti-Human Antibodies:

anti-Mouse (Murine) Antibodies:

All available anti-BTB (POZ) Domain Containing 12 Antibodies

Go to our pre-filtered search.

Top referenced anti-BTB (POZ) Domain Containing 12 Antibodies

  1. Human Polyclonal BTBD12 Primary Antibody for IP - ABIN440495 : Holloway, Mohan, Balmus, Sun, Modzelewski, Borst, Freire, Weiss, Cohen: Mammalian BTBD12 (SLX4) protects against genomic instability during mammalian spermatogenesis. in PLoS genetics 2011 (PubMed)
    Show all 3 references for 440495

  2. Human Polyclonal BTBD12 Primary Antibody for WB - ABIN529697 : Fregoso, Emerman: Activation of the DNA Damage Response Is a Conserved Function of HIV-1 and HIV-2 Vpr That Is Independent of SLX4 Recruitment. in mBio 2016 (PubMed)

  3. Human Polyclonal BTBD12 Primary Antibody for ICC, IF - ABIN440496 : Wan, Yin, Horvath, Sarkar, Chen, Wu, Wan, Lu, Gu, Yu, Lue, Chang, Liu, Lei: SLX4 assembles a telomere maintenance toolkit by bridging multiple endonucleases with telomeres. in Cell reports 2013 (PubMed)

More Antibodies against BTB (POZ) Domain Containing 12 Interaction Partners

Human BTB (POZ) Domain Containing 12 (BTBD12) interaction partners

  1. Data suggest that dimeric GEN1 (show GEN1 Antibodies) binds with high affinity/selectivity to Holliday junctions, introducing two symmetrical hydrolytic cleavages of phosphodiester backbone; at present, less is known about SLX1-SLX4-MUS81 (show MUS81 Antibodies)-EME1 (show EME1 Antibodies) resolving enzyme complex. (GEN1 (show GEN1 Antibodies) = Holliday junction 5' flap (show ALOX5AP Antibodies) endonuclease; SLX = structure-specific endonuclease subunit; MUS81 (show MUS81 Antibodies) = MUS81 (show MUS81 Antibodies) endonuclease; EME1 (show EME1 Antibodies) = essential meiotic endonuclease 1) [REVIEW]

  2. These data also indicate that HIV-1 and HIV-2 Vpr activate the DNA damage response through an SLX4-independent mechanism that remains uncharacterized.

  3. The functioning of SLX4 is dependent on its dimerization via an oligomerization motif called the BTB domain.

  4. SLX4-SLX1 Protein-independent Down-regulation of MUS81 (show MUS81 Antibodies)-EME1 (show EME1 Antibodies) Protein by HIV-1 Viral Protein R (Vpr).

  5. Results identified homozygous mutations in FANCA (show FANCA Antibodies) and FANCP/SLX4 genes, both located on chromosome 16, were the affected recessive FA genes in three and one family respectively. Genotyping with short tandem repeat markers and SNP arrays revealed uniparental disomy of the entire mutation-carrying chromosome 16 in all four patients.

  6. SLX4 (FANCP) and XPF (show ERCC4 Antibodies) (FANCQ) proteins interact with each other and play a vital role in the Fanconi anemia (show PALB2 Antibodies) (FA) DNA repair pathway. Study has revealed that the global minor allele, SLX4(Y546C), is defective in this interaction.

  7. SUMOylation and PARylation cooperate to recruit and stabilize SLX4 at DNA damage sites.

  8. Identification and characterization of MUS81 (show MUS81 Antibodies) point mutations that abolish interaction with the SLX4 scaffold protein (show HOMER1 Antibodies).

  9. Vpr recruits the SLX4 endonuclease complex and Vpr-induced inappropriate activation of this complex leads to cell cycle arrest at the G2 phase.

  10. FANCP has versatile functions in genome maintenance, its mutations result in Fanconi anemia (show PALB2 Antibodies). (Review)

Mouse (Murine) BTB (POZ) Domain Containing 12 (BTBD12) interaction partners

  1. Data shed light on SLX4 recruitment, and they point to the existence of currently unidentified ubiquitylated ligands and E3 ligases that are crucial for ICL repair.

  2. SLX4 is a tumor suppressor, which activates XPF (show ERCC4 Antibodies)-ERCC1 (show ERCC1 Antibodies) nuclease (show DCLRE1C Antibodies) specificity in DNA crosslink repair.

  3. Data indicate that SLX1 and MUS81 (show MUS81 Antibodies)-EME1 (show EME1 Antibodies) nucleases act together to resolve Holliday junctions (HJs) in a manner that requires tethering to SLX4.

  4. these data indicate that BTBD12 functions throughout gametogenesis to maintain genome stability, possibly by co-ordinating repair processes and/or by linking DNA repair events to the cell cycle via ATM (show ATM Antibodies)

  5. mouse Slx4, a regulator of structure-specific nucleases, disruption phenocopies Fanconi anemia (show PALB2 Antibodies)

BTB (POZ) Domain Containing 12 (BTBD12) Antigen Profile

Antigen Summary

This gene encodes a structure-specific endonuclease subunit. The encoded protein contains a central BTB domain and it forms a multiprotein complex with the ERCC4(XPF)-ERCC1, MUS81-EME1, and SLX1 endonucleases, and also associates with MSH2/MSH3 mismatch repair complex, telomere binding complex TERF2(TRF2)-TERF2IP(RAP1), the protein kinase PLK1 and the uncharacterized protein C20orf94. The multiprotein complex is required for repair of specific types of DNA lesions and is critical for cellular responses to replication fork failure. The encoded protein acts as a docking platform for the assembly of multiple structure-specific endonucleases.

Alternative names and synonyms associated with BTB (POZ) Domain Containing 12 (BTBD12)

  • SLX4 structure-specific endonuclease subunit (Slx4) antibody
  • SLX4 structure-specific endonuclease subunit homolog (S. cerevisiae) (SLX4) antibody
  • SLX4 structure-specific endonuclease subunit (SLX4) antibody
  • SLX4 structure-specific endonuclease subunit homolog (S. cerevisiae) (Slx4) antibody
  • AI256635 antibody
  • AI426760 antibody
  • BTBD12 antibody
  • D16Bwg1016e antibody
  • FANCP antibody
  • MUS312 antibody
  • RGD1566009 antibody

Protein level used designations for BTBD12

BTB (POZ) domain containing 12 , SLX4 structure-specific endonuclease subunit homolog , structure-specific endonuclease subunit SLX4 , BTB/POZ domain-containing protein 12

302953 Rattus norvegicus
453866 Pan troglodytes
416665 Gallus gallus
512193 Bos taurus
84464 Homo sapiens
52864 Mus musculus
Selected quality suppliers for anti-BTB (POZ) Domain Containing 12 (BTBD12) Antibodies
Did you look for something else?