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Browse our anti-BTB (POZ) Domain Containing 12 (BTBD12) Antibodies

Full name:
anti-BTB (POZ) Domain Containing 12 Antibodies (BTBD12)
On www.antibodies-online.com are 12 BTB (POZ) Domain Containing 12 (BTBD12) Antibodies from 6 different suppliers available. Additionally we are shipping and many more products for this protein. A total of 16 BTB (POZ) Domain Containing 12 products are currently listed.
Synonyms:
AI256635, AI426760, BTBD12, D16Bwg1016e, FANCP, MUS312, RGD1566009
list all antibodies Gene Name GeneID UniProt
Anti-Rat BTBD12 BTBD12 302953  
BTBD12 84464 Q8IY92
BTBD12 52864 Q6P1D7

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Top referenced anti-BTB (POZ) Domain Containing 12 Antibodies

  1. Human Polyclonal BTBD12 Primary Antibody for ICC, IF - ABIN440496 : Wan, Yin, Horvath, Sarkar, Chen, Wu, Wan, Lu, Gu, Yu, Lue, Chang, Liu, Lei: SLX4 assembles a telomere maintenance toolkit by bridging multiple endonucleases with telomeres. in Cell reports 2013 (PubMed)

More Antibodies against BTB (POZ) Domain Containing 12 Interaction Partners

Human BTB (POZ) Domain Containing 12 (BTBD12) interaction partners

  1. Results identified homozygous mutations in FANCA (show FANCA Antibodies) and FANCP/SLX4 genes, both located on chromosome 16, were the affected recessive FA genes in three and one family respectively. Genotyping with short tandem repeat markers and SNP arrays revealed uniparental disomy of the entire mutation-carrying chromosome 16 in all four patients.

  2. SLX4 (FANCP) and XPF (show ERCC4 Antibodies) (FANCQ) proteins interact with each other and play a vital role in the Fanconi anemia (show PALB2 Antibodies) (FA) DNA repair pathway. Study has revealed that the global minor allele, SLX4(Y546C), is defective in this interaction.

  3. SUMOylation and PARylation cooperate to recruit and stabilize SLX4 at DNA damage sites.

  4. Identification and characterization of MUS81 (show MUS81 Antibodies) point mutations that abolish interaction with the SLX4 scaffold protein (show HOMER1 Antibodies).

  5. Vpr recruits the SLX4 endonuclease complex and Vpr-induced inappropriate activation of this complex leads to cell cycle arrest at the G2 phase.

  6. FANCP has versatile functions in genome maintenance, its mutations result in Fanconi anemia (show PALB2 Antibodies). (Review)

  7. Data shed light on SLX4 recruitment, and they point to the existence of currently unidentified ubiquitylated ligands and E3 ligases that are crucial for ICL repair.

  8. The interactions of SLX4 with SUMO and ubiquitin increase its affinity for factors recognizing different DNA lesions or telomeres, helping to direct the SLX4 complex in distinct functional contexts.

  9. The SLX4 complex is a SUMO E3 ligase (show PIAS1 Antibodies) that SUMOylates SLX4 itself and the XPF (show ERCC4 Antibodies) subunit of the DNA repair/recombination XPF (show ERCC4 Antibodies)-ERCC1 (show ERCC1 Antibodies) endonuclease.

  10. GEN1 activity cannot be substituted for the SLX4-associated nucleases, and one of the HJ resolvase activities, either of those associated with SLX4 or with GEN1, is required for cell viability, even in the presence of BLM.

Mouse (Murine) BTB (POZ) Domain Containing 12 (BTBD12) interaction partners

  1. Data shed light on SLX4 recruitment, and they point to the existence of currently unidentified ubiquitylated ligands and E3 ligases that are crucial for ICL repair.

  2. SLX4 is a tumor suppressor, which activates XPF (show ERCC4 Antibodies)-ERCC1 (show ERCC1 Antibodies) nuclease (show DCLRE1C Antibodies) specificity in DNA crosslink repair.

  3. Data indicate that SLX1 and MUS81 (show MUS81 Antibodies)-EME1 (show EME1 Antibodies) nucleases act together to resolve Holliday junctions (HJs) in a manner that requires tethering to SLX4.

  4. these data indicate that BTBD12 functions throughout gametogenesis to maintain genome stability, possibly by co-ordinating repair processes and/or by linking DNA repair events to the cell cycle via ATM (show ATM Antibodies)

  5. mouse Slx4, a regulator of structure-specific nucleases, disruption phenocopies Fanconi anemia (show PALB2 Antibodies)

BTB (POZ) Domain Containing 12 (BTBD12) Antigen Profile

Antigen Summary

This gene encodes a structure-specific endonuclease subunit. The encoded protein contains a central BTB domain and it forms a multiprotein complex with the ERCC4(XPF)-ERCC1, MUS81-EME1, and SLX1 endonucleases, and also associates with MSH2/MSH3 mismatch repair complex, telomere binding complex TERF2(TRF2)-TERF2IP(RAP1), the protein kinase PLK1 and the uncharacterized protein C20orf94. The multiprotein complex is required for repair of specific types of DNA lesions and is critical for cellular responses to replication fork failure. The encoded protein acts as a docking platform for the assembly of multiple structure-specific endonucleases.

Alternative names and synonyms associated with BTB (POZ) Domain Containing 12 (BTBD12)

  • SLX4 structure-specific endonuclease subunit (Slx4) antibody
  • SLX4 structure-specific endonuclease subunit homolog (S. cerevisiae) (SLX4) antibody
  • SLX4 structure-specific endonuclease subunit (SLX4) antibody
  • SLX4 structure-specific endonuclease subunit homolog (S. cerevisiae) (Slx4) antibody
  • AI256635 antibody
  • AI426760 antibody
  • BTBD12 antibody
  • D16Bwg1016e antibody
  • FANCP antibody
  • MUS312 antibody
  • RGD1566009 antibody

Protein level used designations for BTBD12

BTB (POZ) domain containing 12 , SLX4 structure-specific endonuclease subunit homolog , structure-specific endonuclease subunit SLX4 , BTB/POZ domain-containing protein 12

GENE ID SPECIES
302953 Rattus norvegicus
453866 Pan troglodytes
416665 Gallus gallus
512193 Bos taurus
84464 Homo sapiens
52864 Mus musculus
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