Phone:
+1 877 302 8632
Fax:
+1 888 205 9894 (Toll-free)
E-Mail:
orders@antibodies-online.com

BTBD12 Products

(BTB (POZ) Domain Containing 12 (BTBD12))

Categories

This gene encodes a structure-specific endonuclease subunit. The encoded protein contains a central BTB domain and it forms a multiprotein complex with the ERCC4(XPF)-ERCC1, MUS81-EME1, and SLX1 endonucleases, and also associates with MSH2/MSH3 mismatch repair complex, telomere binding complex TERF2(TRF2)-TERF2IP(RAP1), the protein kinase PLK1 and the uncharacterized protein C20orf94. The multiprotein complex is required for repair of specific types of DNA lesions and is critical for cellular responses to replication fork failure. The encoded protein acts as a docking platform for the assembly of multiple structure-specific endonucleases.[provided by RefSeq, Jan 2011].

antibodies-online.com stands for high-quality research products. Search, find and order tools with extensive validation data, images, references. Our scientific customer service is always at your disposal if you have any questions about the selection or application of our products.

Featured BTBD12 Categories

BTBD12 Antibodies

High quality antibodies with extensive validation data.

Recommended BTBD12 Antibodies

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Application WB
Validations
  • (1)
  • (1)
Cat. No. ABIN529697
Quantity 50 μg
Datasheet Datasheet
Reactivity Human, Monkey
Application WB
Validations
  • (1)
Cat. No. ABIN6746693
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application IP, IHC (p), IHC, IF
Validations
  • (1)
Cat. No. ABIN2571811
Quantity 50 μL
Datasheet Datasheet

Recommended BTBD12 Proteins

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Schizosaccharomyces pombe
Source Yeast
Validations
Cat. No. ABIN1652594
Quantity 1 mg
Datasheet Datasheet

Latest Publications for our BTBD12 products

Sadhukhan, Chowdhury, Ghosh, Ghosh: "Expression of Telomere-Associated Proteins is Interdependent to Stabilize Native Telomere Structure and Telomere Dysfunction by G-Quadruplex Ligand Causes TERRA Upregulation." in: Cell biochemistry and biophysics, (2017) (PubMed).

Fregoso, Emerman: "Activation of the DNA Damage Response Is a Conserved Function of HIV-1 and HIV-2 Vpr That Is Independent of SLX4 Recruitment." in: mBio, Vol. 7, Issue 5, (2016) (PubMed).

Wan, Yin, Horvath, Sarkar, Chen, Wu, Wan, Lu, Gu, Yu, Lue, Chang, Liu, Lei: "SLX4 assembles a telomere maintenance toolkit by bridging multiple endonucleases with telomeres." in: Cell reports, Vol. 4, Issue 5, pp. 861-9, (2013) (PubMed).

Salewsky, Schmiester, Schindler, Digweed, Demuth: "The nuclease hSNM1B/Apollo is linked to the Fanconi anemia pathway via its interaction with FANCP/SLX4." in: Human molecular genetics, Vol. 21, Issue 22, pp. 4948-56, (2012) (PubMed).

Holloway, Mohan, Balmus, Sun, Modzelewski, Borst, Freire, Weiss, Cohen: "Mammalian BTBD12 (SLX4) protects against genomic instability during mammalian spermatogenesis." in: PLoS genetics, Vol. 7, Issue 6, pp. e1002094, (2011) (PubMed).

Kim, Lach, Desetty, Hanenberg, Auerbach, Smogorzewska: "Mutations of the SLX4 gene in Fanconi anemia." in: Nature genetics, Vol. 43, Issue 2, pp. 142-6, (2011) (PubMed).

Synonyms and alternative names related to BTBD12

SLX4 structure-specific endonuclease subunit (Slx4), SLX4 structure-specific endonuclease subunit (SLX4), SLX4 structure-specific endonuclease subunit homolog (SLX4), SLX4 structure-specific endonuclease subunit homolog (S. cerevisiae) (Slx4), AI256635, AI426760, Btbd12, BTBD12, D16Bwg1016e, FANCP, MUS312, RGD1566009

Protein level used designations for BTBD12

  • BTB (POZ) domain containing 12
  • SLX4 structure-specific endonuclease subunit homolog
  • structure-specific endonuclease subunit SLX4
  • BTB/POZ domain-containing protein 12
You are here:
Support