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Browse our DDB2 Proteins (DDB2)

Full name:
Damage-Specific DNA Binding Protein 2, 48kDa Proteins (DDB2)
On www.antibodies-online.com are 9 Damage-Specific DNA Binding Protein 2, 48kDa (DDB2) Proteins from 4 different suppliers available. Additionally we are shipping DDB2 Antibodies (42) and DDB2 Kits (5) and many more products for this protein. A total of 59 DDB2 products are currently listed.
Synonyms:
2610043A19Rik, DDBB, si:dkey-45f10.3, UV-DDB2
list all proteins Gene Name GeneID UniProt
DDB2 107986 Q99J79
Rat DDB2 DDB2 100362121  
DDB2 1643 Q92466

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DDB2 Proteins (DDB2) by Origin

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Top referenced DDB2 Proteins

  1. Human DDB2 Protein expressed in Wheat germ - ABIN1351259 : Robu, Shah, Petitclerc, BrindAmour, Kandan-Kulangara, Shah: Role of poly(ADP-ribose) polymerase-1 in the removal of UV-induced DNA lesions by nucleotide excision repair. in Proceedings of the National Academy of Sciences of the United States of America 2013 (PubMed)

More Proteins for DDB2 Interaction Partners

Mouse (Murine) Damage-Specific DNA Binding Protein 2, 48kDa (DDB2) interaction partners

  1. Results indicate a transcriptional regulatory pathway of DDB2 that is directly linked to the mechanisms that suppress metastasis of colon cancer.

  2. Data indicate that poly(ADP-ribose) polymerase-1 (PARP-1 (show PARP1 Proteins))collaborates with DNA-binding protein (show HSF4 Proteins) 2 (DDB2) to increase the efficiency of the lesion recognition step of global genomic subpathway of NER (show NR1H2 Proteins) (GG-NER (show NR1H2 Proteins)).

  3. the anti-proliferative and the pro-senescence pathways of DDB2 and p21 are critical protection mechanisms against skin malignancies.

  4. Results show that, upon oxidative stress, DDB2 functions in a positive feedback loop by repressing the antioxidant genes to cause persistent accumulation of ROS (show ROS1 Proteins) and induce premature senescence.

  5. These results demonstrate direct activation of the human DDB2 gene by p53 (show TP53 Proteins). The corresponding region in the mouse DDB2 gene shared significant sequence identity with the human gene but was deficient for p53 (show TP53 Proteins) binding and transcriptional activation.

  6. results demonstrate that DDB2 is well conserved between humans and mice and functions as a tumor suppressor, at least in part, by controlling p53 (show TP53 Proteins)-mediated apoptosis after UV-irradiation

  7. DDB2-deficient mice developed spontaneous malignant tumors at a high rate between the ages of 20 and 25 months.

  8. DDB2 is involved in global repair in mouse epithelial cells.

  9. Ddb2 heterozygosity can facilitate tumor development as a haploinsufficient tumor suppressor

  10. results indicate the bulk of DDB2 interacts with lesions independent of XPC (show XPC Proteins) & there is little interaction between the two recognition proteins on damaged DNA; propose a scenario in which DDB2 prepares UV-damaged chromatin for assembly of the NER (show NR1H2 Proteins) complex

Human Damage-Specific DNA Binding Protein 2, 48kDa (DDB2) interaction partners

  1. the release of NER (show NR1H2 Proteins) components such as DNA damage binding protein 2 (DDB2) and Xeroderma Pigmentosum complementation group C (show XPC Proteins) protein (show HNRNPC Proteins) (XPC (show XPC Proteins)) following oxidative stress might putatively involve their apoptotic role rather than DNA repair function.

  2. PKM2 interacts with DDB2 and reduces cell survival upon UV irradiation.

  3. DDB2 can bind to the promoter region of NEDD4L (show NEDD4L Proteins) and recruit enhancer of zeste homolog 2 (show EZH2 Proteins) histone methyltransferase to repress NEDD4L (show NEDD4L Proteins) transcription by enhancing histone H3 (show HIST3H3 Proteins) lysine 27 trimethylation at the NEDD4L (show NEDD4L Proteins) promoter.

  4. data demonstrated that the DDB2 IRES activity was promoted during stress conditions. These results reveal a novel mechanism contributing to DDB2 expression

  5. DDB2 is involved in ubiquitination and degradation of PAQR3 (show PAQR3 Proteins) in gastric cancer cells.

  6. DDB2 rs747650 is involved in androgen metabolism, inflammation processes and scar formation in severe acne.

  7. DDB2 plays an instrumental role in DNA damage induced ROS (show ROS1 Proteins) accumulation, ROS (show ROS1 Proteins) induced premature senescence and inhibition of skin tumorigenesis.

  8. DDB2 is protected by XPC (show XPC Proteins) from ubiquitination and degradation in a stochastic manner; thus XPC (show XPC Proteins) allows DDB2 to initiate multiple rounds of repair events, thereby contributing to the persistence of cellular DNA repair capacity

  9. DDB2 protein expression is low in ovarian tumor cells.

  10. Data support a model wherein DDB1 (show DDB1 Proteins) and DDB2 cooperate to repress Bcl-2 (show BCL2 Proteins) transcription. DDB2 recognizes and binds to the Bcl-2 (show BCL2 Proteins) P1 promoter, and HDAC1 (show HDAC1 Proteins) is recruited through the DDB1 (show DDB1 Proteins) subunit associated with DDB2 to deacetylate histone H3K9.

DDB2 Protein Profile

Protein Summary

This gene encodes a protein that is necessary for the repair of ultraviolet light-damaged DNA. This protein is the smaller subunit of a heterodimeric protein complex that participates in nucleotide excision repair, and this complex mediates the ubiquitylation of histones H3 and H4, which facilitates the cellular response to DNA damage. This subunit appears to be required for DNA binding. Mutations in this gene cause xeroderma pigmentosum complementation group E, a recessive disease that is characterized by an increased sensitivity to UV light and a high predisposition for skin cancer development, in some cases accompanied by neurological abnormalities.

Alternative names and synonyms associated with DDB2

  • damage-specific DNA binding protein 2, 48kDa (DDB2)
  • damage-specific DNA binding protein 2, 48kDa (ddb2)
  • damage specific DNA binding protein 2 (Ddb2)
  • damage-specific DNA binding protein 2 (ddb2)
  • 2610043A19Rik protein
  • DDBB protein
  • si:dkey-45f10.3 protein
  • UV-DDB2 protein

Protein level used designations for DDB2

damage-specific DNA binding protein 2 (48kD) , damage-specific DNA binding protein 2, 48kDa , DNA damage-binding protein 2 , Damage-specific DNA-binding protein 2 , DNA damage-binding protein 2-like , damage-specific DNA-binding protein 2 , DDB p48 subunit , UV-DDB 2 , UV-damaged DNA-binding protein 2 , xeroderma pigmentosum group E protein

GENE ID SPECIES
100051180 Equus caballus
451165 Pan troglodytes
483626 Canis lupus familiaris
493565 Xenopus (Silurana) tropicalis
713813 Macaca mulatta
100352386 Oryctolagus cuniculus
100390419 Callithrix jacchus
100454099 Pongo abelii
100605065 Nomascus leucogenys
107986 Mus musculus
100362121 Rattus norvegicus
100004133 Danio rerio
1643 Homo sapiens
519357 Bos taurus
423185 Gallus gallus
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