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Browse our Ligase IV, DNA, ATP-Dependent Proteins (LIG4)

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Ligase IV, DNA, ATP-Dependent Proteins (LIG4)
On are 3 Ligase IV, DNA, ATP-Dependent (LIG4) Proteins from 2 different suppliers available. Additionally we are shipping Ligase IV, DNA, ATP-Dependent Antibodies (64) and Ligase IV, DNA, ATP-Dependent Kits (1) and many more products for this protein. A total of 75 Ligase IV, DNA, ATP-Dependent products are currently listed.
5830471N16Rik, DNA LIGASE IV, DNL4, LIG4, lig4-A, tiny, zgc:165595
list all proteins Gene Name GeneID UniProt
LIG4 3981 P49917
LIG4 319583 Q8BTF7
Rat LIG4 LIG4 290907  

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Ligase IV, DNA, ATP-Dependent Proteins (LIG4) by Origin

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More Proteins for Ligase IV, DNA, ATP-Dependent Interaction Partners

Arabidopsis thaliana Ligase IV, DNA, ATP-Dependent (LIG4) interaction partners

  1. DNA ligase IV (LIG4) is not essential for telomere joining.

Human Ligase IV, DNA, ATP-Dependent (LIG4) interaction partners

  1. The rs1805388 in LIG4 was associated with increased radioresistance.

  2. LIG4 is highly upregulated in human colorectal cancer cells.

  3. Five novel mutations in LIG4 and a potential hotspot mutation (c.833G > T; p.R278L) in the Chinese population with LIG4 deficiency syndrome were identified.

  4. Our study identifies LIG4 as a predictor of an increased risk for early biochemical recurrence in prostate cancer

  5. The genetic polymorphisms in LIG4 rs1805388 and HSPB1 (show HSPB1 Proteins) rs2868371 were not obviously correlated with the risk of radiation pneumonitis and radiation-induced lung injury of lung cancer.

  6. our results suggest that LIG4 rs10131 polymorphism in the DNA repair pathways plays an important role in the risk of glioma in a Chinese population.

  7. Our data showed that Cd altered the phosphorylation of DNA-PKcs (show PRKDC Proteins), and reduced the expression of both XRCC4 (show XRCC4 Proteins) and Ligase IV in irradiated cells.

  8. despite several limitations, this meta-analysis suggested that LIG4 T9I genetic variant is associated with a decreased risk of cancer among Caucasians, however, the rs1805386 gene polymorphism is not a risk factor of cancer.

  9. High LIG4 expression is associated with less radiosensitivity of nasopharyngeal cancer.

  10. DNA Ligase IV is required for efficient localization of XRCC4 (show XRCC4 Proteins) and XLF (show NHEJ1 Proteins) into cell nucleus.

Mouse (Murine) Ligase IV, DNA, ATP-Dependent (LIG4) interaction partners

  1. The data firmly demonstrate Lig4(R278H) activity renders nonhomologous end-joining (NHEJ) DNA repair to be more error-prone, and predict increased error-prone NHEJ and A-EJ suppression as the cause of defective B lymphopoiesis in Lig4 patients.

  2. To promote homology-directed r at the expense of nonhomologous end joining , we targeted DNA ligase IV, a key enzyme in the NHEJ pathway, using the inhibitor Scr7. This approach should be applicable to other customizable endonucleases

  3. Lig4 and XRCC1 (show XRCC1 Proteins) double-deficient cells switch as efficiently as Lig4-deficient cells, clearly indicating that XRCC1 (show XRCC1 Proteins) is dispensable for A-EJ in CH12F3 cells during class switch recombination

  4. These studies provide insight into the interplay between DNA damage responses in the developing brain and the DNA ligase IV plat (show PLAT Proteins) the role in repairing endogenously arising DNA double-strand breaks.

  5. Lig4-deficient B cells have reduced, but still substantial, immunoglobulins class switch recombination

  6. Homozygous DNA ligase IV R278H mutation in mice leads to leaky SCID (show PRKDC Proteins) and represents a model for human LIG4 syndrome.

  7. Lig4 and Rad54 (show RAD54L Proteins) cooperate to support cellular proliferation, dna repair, and prevent chromosome and single chromatid aberrations

  8. LIG4 mutations can result in either a developmental defect with immunological abnormalities or a severe combined immunodeficiency (show PRKDC Proteins) picture with normal development.

  9. DNA Ligase IV is engaged in extrachromosomal circular major satellite DNA synthesis

  10. DNA-PK kinase activity results in disassembly of the Ku/DNA ligase IV/Xrcc4 (show XRCC4 Proteins) complex

Ligase IV, DNA, ATP-Dependent (LIG4) Protein Profile

Protein Summary

The protein encoded by this gene is a DNA ligase that joins single-strand breaks in a double-stranded polydeoxynucleotide in an ATP-dependent reaction. This protein is essential for V(D)J recombination and DNA double-strand break (DSB) repair through nonhomologous end joining (NHEJ). This protein forms a complex with the X-ray repair cross complementing protein 4 (XRCC4), and further interacts with the DNA-dependent protein kinase (DNA-PK). Both XRCC4 and DNA-PK are known to be required for NHEJ. The crystal structure of the complex formed by this protein and XRCC4 has been resolved. Defects in this gene are the cause of LIG4 syndrome. Alternatively spliced transcript variants encoding the same protein have been observed.

Alternative names and synonyms associated with Ligase IV, DNA, ATP-Dependent (LIG4)

  • ligase IV, DNA, ATP-dependent (lig4)
  • ligase IV, DNA, ATP-dependent (LIG4)
  • DNA ligase 4-like (LOC100212302)
  • DNA ligase 4 (CpipJ_CPIJ005161)
  • DNA ligase 4 (PTRG_09982)
  • DNA ligase 4 (MCYG_05151)
  • ligase IV, DNA, ATP-dependent (Lig4)
  • ATP-dependent DNA ligase implicated in dsDNA break repair via nonhomologous end-joining (LIG4)
  • DNA ligase 4 (ATLIG4)
  • 5830471N16Rik protein
  • DNA LIGASE IV protein
  • DNL4 protein
  • LIG4 protein
  • lig4-A protein
  • tiny protein
  • zgc:165595 protein

Protein level used designations for LIG4

DNA ligase 4 , ligase IV, DNA, ATP-dependent , DNA ligase IV , DNA ligase (ATP) 4 , GLEAN_12219 , ligase4-like protein , DNA ligase 4-like , dsDNA break repair ligase , polydeoxyribonucleotide synthase [ATP] 4 , DNA joinase , DNA repair enzyme , polynucleotide ligase , sealase

569525 Danio rerio
781252 Bos taurus
100051479 Equus caballus
100212302 Hydra magnipapillata
6036973 Culex quinquefasciatus
6348281 Pyrenophora tritici-repentis Pt-1C-BFP
9230237 Arthroderma otae CBS 113480
452653 Pan troglodytes
549735 Xenopus (Silurana) tropicalis
657210 Tribolium castaneum
100476294 Ailuropoda melanoleuca
100600607 Nomascus leucogenys
3643043 Candida albicans SC5314
835822 Arabidopsis thaliana
394389 Xenopus laevis
418764 Gallus gallus
3981 Homo sapiens
485544 Canis lupus familiaris
319583 Mus musculus
290907 Rattus norvegicus
100173511 Pongo abelii
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