LIG4 Products
(Ligase IV, DNA, ATP-Dependent (LIG4))
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The protein encoded by this gene is a DNA ligase that joins single-strand breaks in a double-stranded polydeoxynucleotide in an ATP-dependent reaction. This protein is essential for V(D)J recombination and DNA double-strand break (DSB) repair through nonhomologous end joining (NHEJ). This protein forms a complex with the X-ray repair cross complementing protein 4 (XRCC4), and further interacts with the DNA-dependent protein kinase (DNA-PK). Both XRCC4 and DNA-PK are known to be required for NHEJ. The crystal structure of the complex formed by this protein and XRCC4 has been resolved. Defects in this gene are the cause of LIG4 syndrome. Alternatively spliced transcript variants encoding the same protein have been observed. [provided by RefSeq, Jul 2008].
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Featured LIG4 Categories
LIG4 Antibodies
High quality antibodies with extensive validation data.
LIG4 ELISA Kits
Reliable ELISA kits for a wide range of species.
LIG4 Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended LIG4 Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human, Mouse, Rat
Application
WB, ELISA, IHC, IF, ICC
Validations
- (4)
Cat. No.
ABIN6262967
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, IHC
Validations
- (2)
- (3)
Cat. No.
ABIN3022475
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat
Application
WB, IHC
Validations
- (4)
Cat. No.
ABIN2778272
Quantity
100 μL
Datasheet
Datasheet
Recommended LIG4 ELISA Kits
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
Cat. No.
ABIN6216177
Quantity
96 tests
Datasheet
Datasheet
Recommended LIG4 Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1309405
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Tobacco (Nicotiana tabacum)
Validations
- (1)
Cat. No.
ABIN3092165
Quantity
1 mg
Datasheet
Datasheet
Reactivity
Mouse
Source
Tobacco (Nicotiana tabacum)
Validations
- (1)
Cat. No.
ABIN3136262
Quantity
1 mg
Datasheet
Datasheet
Latest Publications for our LIG4 products
: "TOP2β-Dependent Nuclear DNA Damage Shapes Extracellular Growth Factor Responses via Dynamic AKT Phosphorylation to Control Virus Latency." in: Molecular cell, Vol. 74, Issue 3, pp. 466-480.e4, (2019) (PubMed).: "Histone H3K27 methylation modulates the dynamics of FANCD2 on chromatin to facilitate NHEJ and genome stability." in: Journal of cell science, Vol. 131, Issue 12, (2018) (PubMed).
: "Impaired DNA double-strand break repair contributes to the age-associated rise of genomic instability in humans." in: Cell death and differentiation, Vol. 23, Issue 11, pp. 1765-1777, (2017) (PubMed).
: "Selective Y centromere inactivation triggers chromosome shattering in micronuclei and repair by non-homologous end joining." in: Nature cell biology, Vol. 19, Issue 1, pp. 68-75, (2017) (PubMed).
: "Protein phosphatase 1 and phosphatase 1 nuclear targeting subunit-dependent regulation of DNA-dependent protein kinase and non-homologous end joining." in: Nucleic acids research, Vol. 45, Issue 18, pp. 10583-10594, (2017) (PubMed).
: "An inverse switch in DNA base excision and strand break repair contributes to melphalan resistance in multiple myeloma cells." in: PLoS ONE, Vol. 8, Issue 2, pp. e55493, (2013) (PubMed).
: "The human adenovirus type 5 E1B 55-kilodalton protein is phosphorylated by protein kinase CK2." in: Journal of virology, Vol. 86, Issue 5, pp. 2400-15, (2012) (PubMed).
: "The HTLV-1 Tax oncoprotein represses Ku80 gene expression." in: Virology, Vol. 416, Issue 1-2, pp. 1-8, (2011) (PubMed).
Synonyms and alternative names related to LIG4
ligase IV, DNA, ATP-dependent (lig4), DNA ligase 4 (LIG4), DNA ligase 4 (LOC100212302), DNA ligase 4 (CpipJ_CPIJ005161), DNA ligase 4 (PTRG_09982), DNA ligase 4 (MCYG_05151), DNA ligase 4 (LOC657210), ATP-dependent DNA ligase implicated in dsDNA break repair via nonhomologous end-joining (LIG4), DNA ligase IV (ATLIG4), ligase IV, DNA, ATP-dependent L homeolog (lig4.L), ligase IV, DNA, ATP-dependent (Lig4), DNA ligase 4 (Lig4), 5830471N16Rik, DNA LIGASE IV, DNL4, lig4, LIG4, lig4-A, tiny, zgc:165595Protein level used designations for LIG4
- DNA ligase 4
- ligase IV, DNA, ATP-dependent
- DNA ligase IV
- DNA ligase (ATP) 4
- GLEAN_12219
- ligase4-like protein
- DNA ligase 4-like
- dsDNA break repair ligase
- polydeoxyribonucleotide synthase [ATP] 4
- DNA joinase
- DNA repair enzyme
- polynucleotide ligase
- sealase
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