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Browse our anti-MLH1 (MLH1) Antibodies

Full name:
anti-MutL Homolog 1, Colon Cancer, Nonpolyposis Type 2 (E. Coli) Antibodies (MLH1)
On are 176 MutL Homolog 1, Colon Cancer, Nonpolyposis Type 2 (E. Coli) (MLH1) Antibodies from 27 different suppliers available. Additionally we are shipping MLH1 Proteins (6) and MLH1 Kits (2) and many more products for this protein. A total of 191 MLH1 products are currently listed.
1110035C23Rik, AI317206, AI325952, AI561766, CG11482, COCA2, Dmel\\CG11482, dmlh-1, dmlh1, FCC2, hMLH1, HNPCC, HNPCC2, LOC100232198, MLH1, zgc:66301

Most Popular Reactivities for anti-MLH1 (MLH1) Antibodies

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anti-Mouse (Murine) MLH1 Antibodies:

anti-Human MLH1 Antibodies:

anti-Rat (Rattus) MLH1 Antibodies:

All available anti-MLH1 Antibodies

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Top referenced anti-MLH1 Antibodies

  1. Human Monoclonal MLH1 Primary Antibody for IHC (fro), IHC (p) - ABIN967314 : Baker, Plug, Prolla, Bronner, Harris, Yao, Christie, Monell, Arnheim, Bradley, Ashley, Liskay: Involvement of mouse Mlh1 in DNA mismatch repair and meiotic crossing over. in Nature genetics 1996 (PubMed)
    Show all 7 references for ABIN967314

  2. Human Monoclonal MLH1 Primary Antibody for ICC, IHC - ABIN969285 : Geary, Sasieni, Houlston, Izatt, Eeles, Payne, Fisher, Hodgson: Gene-related cancer spectrum in families with hereditary non-polyposis colorectal cancer (HNPCC). in Familial cancer 2008 (PubMed)
    Show all 3 references for ABIN969285

  3. Human Monoclonal MLH1 Primary Antibody for IP, WB - ABIN967392 : Prolla, Christie, Liskay: Dual requirement in yeast DNA mismatch repair for MLH1 and PMS1, two homologs of the bacterial mutL gene. in Molecular and cellular biology 1994 (PubMed)
    Show all 3 references for ABIN967392

  4. Human Polyclonal MLH1 Primary Antibody for ELISA, WB - ABIN1534468 : Bronner, Baker, Morrison, Warren, Smith, Lescoe, Kane, Earabino, Lipford, Lindblom: Mutation in the DNA mismatch repair gene homologue hMLH1 is associated with hereditary non-polyposis colon cancer. in Nature 1994 (PubMed)
    Show all 2 references for ABIN1534468

  5. Hamster Monoclonal MLH1 Primary Antibody for IHC (fro), IHC (p) - ABIN115273 : Machin, Catasus, Pons, Muñoz, Conde-Zurita, Balmaña, Barnadas, Martí, Prat, Matias-Guiu: Microsatellite instability and immunostaining for MSH-2 and MLH-1 in cutaneous and internal tumors from patients with the Muir-Torre syndrome. in Journal of cutaneous pathology 2002 (PubMed)

  6. Hamster Monoclonal MLH1 Primary Antibody for IHC (p) - ABIN115274 : Pearson, Pinkerton, Lewis, Imeson, Ellershaw, Machin, ,: High-dose rapid and standard induction chemotherapy for patients aged over 1 year with stage 4 neuroblastoma: a randomised trial. in The lancet oncology 2008 (PubMed)

  7. Human Polyclonal MLH1 Primary Antibody for IHC (p), IP - ABIN151469 : Shen, Hu, Jeng, Chang, Lin, Chang, Hsu, Cheng: Nuclear overexpression of mitotic regulatory proteins in biliary tract cancer: correlation with clinicopathologic features and patient survival. in Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2009 (PubMed)

  8. Chicken Polyclonal MLH1 Primary Antibody for WB - ABIN2786501 : Harley, Rosen, Risch, Siminovitch, Beiner, McLaughlin, Sun, Narod: Ovarian cancer risk is associated with a common variant in the promoter sequence of the mismatch repair gene MLH1. in Gynecologic oncology 2008 (PubMed)

More Antibodies against MLH1 Interaction Partners

Xenopus laevis MutL Homolog 1, Colon Cancer, Nonpolyposis Type 2 (E. Coli) (MLH1) interaction partners

  1. Results suggest that Xenopus MBD4 (show MBD4 Antibodies)/MLH1 participates in a novel G2 checkpoint that is responsive to DNMT1p levels in developing embryos and cells.

Zebrafish MutL Homolog 1, Colon Cancer, Nonpolyposis Type 2 (E. Coli) (MLH1) interaction partners

  1. Male mlh1 mutants are sterile and display an arrest in spermatogenesis at metaphase I, resulting in increased testis weight due to accumulation of prophase I spermatocytes.

  2. In zebrafish mlh1 mutant (knock-out) males, a delay of both meiotic divisions occurs rather than complete arrest during meiosis I. Eggs fertilized with mutant sperm develop as malformed embryos and are aneuploid.

  3. Identification and characterization of novel knockout mutants of the three major MMR (show MRC1 Antibodies) genes, mlh1, msh2 (show MSH2 Antibodies), and msh6 (show MSH6 Antibodies), in zebrafish that develop tumors at low frequencies.

Mouse (Murine) MutL Homolog 1, Colon Cancer, Nonpolyposis Type 2 (E. Coli) (MLH1) interaction partners

  1. radiation exposure could further increase the risk of colorectal carcinogenesis induced by inflammation under the conditions of Mlh1 deficiency.

  2. these data identify Mlh1 and Mlh3 (show MLH3 Antibodies) as novel critical genetic modifiers of HTT (show HTT Antibodies) CAG instability, point to Mlh1 genetic variation as the likely source of the instability difference in B6 and 129 strains

  3. Data indicate that Mlh1 showed only modest methylation was still expressed in both Mlh1(+/-) and Mlh1(+/+) mice.

  4. nickel-smelting fumes upregulated the expression of Mlh1 protein, mouse . This suggest that nickel-smelting fumes could be toxic to cells, inducing cell apoptosis and necrosis.

  5. suggesting a role for the ATPase (show DNAH8 Antibodies) activity of MLH1 beyond the activation of the endonuclease functions of its MMR (show MRC1 Antibodies) partner PMS2 (show PMS2 Antibodies)

  6. Down-regulation of MLH1 is associated with initiation and growth of neuroblastoma (show ARHGEF16 Antibodies) and brain tumour multicellular spheroids.

  7. MLH1 can convert DNA nicks and point mutations into double-stranded DNA breaks for both core nonhomologous end-joining factors and alternative end-joining pathways of class-switch recombination.

  8. Data show that the constitutive inactivation of MLH1, resulting Mlh1(Deltaex4/Deltaex4) mouse line, displays complete MMR (show MRC1 Antibodies) deficiency and a cancer predisposition phenotype similar to Mlh1-/- mice.

  9. Ablation of Mlh1 did not appreciably influence the developmental phenotypes conferred by the absence of Rad51d (show RAD51D Antibodies).

  10. Role for mismatch repair proteins Msh2 (show MSH2 Antibodies), Mlh1, and Pms2 (show PMS2 Antibodies) in immunoglobulin class switching shown by sequence analysis of recombination junctions.

Human MutL Homolog 1, Colon Cancer, Nonpolyposis Type 2 (E. Coli) (MLH1) interaction partners

  1. A total of 201 unique disease-predisposing mismatch repair gene mutations were identified in 369 Lynch syndrome families. These mutations affected MLH1 in 40%, MSH2 (show MSH2 Antibodies) in 36%, MSH6 (show MSH6 Antibodies) in 18% and PMS2 (show PMS2 Antibodies) in 6% of the families

  2. Loss of MLH1 expression was however observed in none of those including four Microsatellite instability + tumours . Expression of MSH2 (show MSH2 Antibodies), another essential MMR (show MRC1 Antibodies) gene, was also examined, but no alterations were found

  3. Individuals who carry a MMR (show MRC1 Antibodies) gene (MLH1, MSH2 (show MSH2 Antibodies), PMS2 (show PMS2 Antibodies) or MSH6 (show MSH6 Antibodies)) mutation are at an increased risk of developing cancers at multiple sites, most notably colorectal and endometrial carcinomas.

  4. The DNA methylation (show HELLS Antibodies) of both Reprimo and hMLH1 genes depressed the protein expression, and may participate in the occurrence and progression and gastric cancer

  5. data supported an interdependence of mismatch repair proteins, particularly MLH1 and MSH2 (show MSH2 Antibodies), in the mediation of apoptosis in human colorectal carcinoma cell lines

  6. MLH1 Promoter Region Methylation is associated with colorectal cancer.

  7. In Lynch syndrome families, prostate cancer was associated with mutations in MLH1 with loss of the mismatch repair protein (show MSH2 Antibodies).

  8. DAPK-1 (show DAPK1 Antibodies) and MLH1 methylation correlated inversely in tumors in the middle-third of the stomach

  9. Loss of MLH-1/PMS-2 (show PMS2 Antibodies) expression was associated with right-colon location, poor and mucinous differentiation and dense lymphocytic infiltration in colorectal adenocarcinoma.

  10. Pathogenic mutations were only confined to MLH1 and identified in 28.8% of Singapore families with Hereditary Colorectal Cancer.

Cow (Bovine) MutL Homolog 1, Colon Cancer, Nonpolyposis Type 2 (E. Coli) (MLH1) interaction partners

  1. Meiosis progression and female age affect expression profile of DNA repair MLH1 gene in bovine oocytes.

MLH1 Antigen Profile

Antigen Summary

This gene was identified as a locus frequently mutated in hereditary nonpolyposis colon cancer (HNPCC). It is a human homolog of the E. coli DNA mismatch repair gene mutL, consistent with the characteristic alterations in microsatellite sequences (RER+phenotype) found in HNPCC. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional transcript variants have been described, but their full-length natures have not been determined.

Alternative names and synonyms associated with MLH1

  • mutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli) (MLH1) antibody
  • CG11482 gene product from transcript CG11482-RB (Mlh1) antibody
  • mutL homolog 1, colon cancer, nonpolyposis type 2 (mlh1) antibody
  • mutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli) (mlh1) antibody
  • mutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli) (LOC100232198) antibody
  • mutL homolog 1 (E. coli) (Mlh1) antibody
  • mutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli) (Mlh1) antibody
  • 1110035C23Rik antibody
  • AI317206 antibody
  • AI325952 antibody
  • AI561766 antibody
  • CG11482 antibody
  • COCA2 antibody
  • Dmel\\CG11482 antibody
  • dmlh-1 antibody
  • dmlh1 antibody
  • FCC2 antibody
  • hMLH1 antibody
  • HNPCC antibody
  • HNPCC2 antibody
  • LOC100232198 antibody
  • MLH1 antibody
  • zgc:66301 antibody

Protein level used designations for MLH1

MutL protein homolog 1 , CG11482-PA , CG11482-PB , Mlh1-PA , Mlh1-PB , DNA mismatch repair protein Mlh1 , mutL-like protein 1 , mutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli) , DNA mismatch repair protein Mlh1-like , colon cancer, nonpolyposis type 2 , mutL protein homolog 1 , mismatch repair protein 1

420729 Gallus gallus
35796 Drosophila melanogaster
100036779 Xenopus laevis
100337665 Sus scrofa
393632 Danio rerio
588545 Strongylocentrotus purpuratus
747104 Pan troglodytes
100011682 Monodelphis domestica
100050351 Equus caballus
100232198 Taeniopygia guttata
100406787 Callithrix jacchus
100436876 Pongo abelii
100476536 Ailuropoda melanoleuca
100555611 Anolis carolinensis
100593390 Nomascus leucogenys
17350 Mus musculus
4292 Homo sapiens
81685 Rattus norvegicus
477019 Canis lupus familiaris
533652 Bos taurus
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