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anti-Mouse (Murine) MLH1 Antibodies:
anti-Human MLH1 Antibodies:
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Human Monoclonal MLH1 Primary Antibody for IHC (fro), IHC (p) - ABIN967315
Baker, Plug, Prolla, Bronner, Harris, Yao, Christie, Monell, Arnheim, Bradley, Ashley, Liskay: Involvement of mouse Mlh1 in DNA mismatch repair and meiotic crossing over. in Nature genetics 1996
Show all 8 Pubmed References
Human Monoclonal MLH1 Primary Antibody for IHC (f), IHC (fro) - ABIN2689847
Cleaver: It was a very good year for DNA repair. in Cell 1994
Show all 5 Pubmed References
Human Monoclonal MLH1 Primary Antibody for ICC, IHC - ABIN969285
Geary, Sasieni, Houlston, Izatt, Eeles, Payne, Fisher, Hodgson: Gene-related cancer spectrum in families with hereditary non-polyposis colorectal cancer (HNPCC). in Familial cancer 2008
Show all 3 Pubmed References
Human Monoclonal MLH1 Primary Antibody for IP, WB - ABIN967392
Prolla, Christie, Liskay: Dual requirement in yeast DNA mismatch repair for MLH1 and PMS1, two homologs of the bacterial mutL gene. in Molecular and cellular biology 1994
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Human Polyclonal MLH1 Primary Antibody for IHC (p), IP - ABIN151469
Shen, Hu, Jeng, Chang, Lin, Chang, Hsu, Cheng: Nuclear overexpression of mitotic regulatory proteins in biliary tract cancer: correlation with clinicopathologic features and patient survival. in Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2009
Hamster Monoclonal MLH1 Primary Antibody for IHC (p) - ABIN115274
Pearson, Pinkerton, Lewis, Imeson, Ellershaw, Machin, ,: High-dose rapid and standard induction chemotherapy for patients aged over 1 year with stage 4 neuroblastoma: a randomised trial. in The lancet oncology 2008
Results suggest that Xenopus MBD4 (show MBD4 Antibodies)/MLH1 participates in a novel G2 checkpoint that is responsive to DNMT1p levels in developing embryos and cells.
Male mlh1 mutants are sterile and display an arrest in spermatogenesis at metaphase I, resulting in increased testis weight due to accumulation of prophase I spermatocytes.
In zebrafish mlh1 mutant (knock-out) males, a delay of both meiotic divisions occurs rather than complete arrest during meiosis I. Eggs fertilized with mutant sperm develop as malformed embryos and are aneuploid.
Identification and characterization of novel knockout mutants of the three major MMR (show MRC1 Antibodies) genes, mlh1, msh2 (show MSH2 Antibodies), and msh6 (show MSH6 Antibodies), in zebrafish that develop tumors at low frequencies.
a causal relationship between MLH1-deficiency and incidence of oncogenic point mutations in tyrosine kinases driving cell transformation and acquired resistance to kinase-targeted cancer therapies, is reported.
high mutation ofMlh1(-/-)-deficient fetuses has little effect on the fetuses during their early developmental stages, whereas Mlh1(-/-)-deficient fetuses from X-ray irradiated mothers are clearly effected
radiation exposure could further increase the risk of colorectal carcinogenesis induced by inflammation under the conditions of Mlh1 deficiency.
these data identify Mlh1 and Mlh3 (show MLH3 Antibodies) as novel critical genetic modifiers of HTT (show HTT Antibodies) CAG instability, point to Mlh1 genetic variation as the likely source of the instability difference in B6 and 129 strains
Data indicate that Mlh1 showed only modest methylation was still expressed in both Mlh1(+/-) and Mlh1(+/+) mice.
nickel-smelting fumes upregulated the expression of Mlh1 protein, mouse . This suggest that nickel-smelting fumes could be toxic to cells, inducing cell apoptosis and necrosis.
suggesting a role for the ATPase (show DNAH8 Antibodies) activity of MLH1 beyond the activation of the endonuclease functions of its MMR (show MRC1 Antibodies) partner PMS2 (show PMS2 Antibodies)
Down-regulation of MLH1 is associated with initiation and growth of neuroblastoma (show ARHGEF16 Antibodies) and brain tumour multicellular spheroids.
MLH1 can convert DNA nicks and point mutations into double-stranded DNA breaks for both core nonhomologous end-joining factors and alternative end-joining pathways of class-switch recombination.
Data show that the constitutive inactivation of MLH1, resulting Mlh1(Deltaex4/Deltaex4) mouse line, displays complete MMR (show MRC1 Antibodies) deficiency and a cancer predisposition phenotype similar to Mlh1-/- mice.
Promoter methylation and loss of protein expression of hMLH1 are not parallel processes that occur concurrently. hMLH1 methylation is an early molecular event which occurs even in hyperplastic polyps (HPs (show HPS1 Antibodies)). the loss of hMLH1 protein expression does not necessarily precede the development of cytological dysplasia in sessile serrated lesion (SSL).
Overexpression of MutL homolog 1 and MutS homolog 2 (show MSH2 Antibodies) proteins have reversed prognostic implications for stage I-II colon cancer
MLH1, a key protein involved in mismatch repair (MMR (show MRC1 Antibodies)), suppresses telomeric sequence insertion (TSI) at intra-chromosomal regions. The frequency of TSI can be elevated by double-strand break (DSB) inducer and abolished by ATM (show ATM Antibodies)/ATR (show ANTXR1 Antibodies) inhibition. Suppression of TSI requires MLH1 recruitment to DSBs, indicating that MLH1's role in DSB response/repair is important for suppressing TSI.
MLH1 mutations contribute to colorectal cancer susceptibility in Algerian families with suspected Lynch syndrome.
MLH1 methylation analysis defines a subset of tumors that have worse prognostic features including higher tumor volume and lymph node involvement.
High MLH1 expression is associated with the development of genetic instability and is linked to tumor aggressiveness and early PSA recurrence in prostate cancer.
MLH1 methylation is a frequent molecular event in colorectal cancer and lung cancer patients
Both the mTOR (show FRAP1 Antibodies)/p-mTOR (show FRAP1 Antibodies) and BNIP3 (show BNIP3 Antibodies)/Beclin-1 (show BECN1 Antibodies) signaling pathways were found to be related to HRS, but only mTOR (show FRAP1 Antibodies)/p-mTOR (show FRAP1 Antibodies) is involved in the regulation of HRS via MLH1 and autophagy.
Data suggest that yeast Mlh1-Mlh3 (show MLH3 Antibodies) heterodimer does not exhibit hallmarks of a canonical (structure-selective) Holliday junction resolvase/endonuclease; multiple Mlh1-Mlh3 (show MLH3 Antibodies) heterodimers appear to load onto DNA to form an activated polymer that cleaves DNA; human MLH1-PMS2 (show PMS2 Antibodies) exhibits similar characteristics. (MLH = mutL homolog protein; PMS2 (show PMS2 Antibodies) = post meiotic segregation increased 2 protein)
Meiosis progression and female age affect expression profile of DNA repair MLH1 gene in bovine oocytes.
This gene was identified as a locus frequently mutated in hereditary nonpolyposis colon cancer (HNPCC). It is a human homolog of the E. coli DNA mismatch repair gene mutL, consistent with the characteristic alterations in microsatellite sequences (RER+phenotype) found in HNPCC. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional transcript variants have been described, but their full-length natures have not been determined.
MutL protein homolog 1
, DNA mismatch repair protein Mlh1
, mutL-like protein 1
, mutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli)
, DNA mismatch repair protein Mlh1-like
, colon cancer, nonpolyposis type 2
, mutL protein homolog 1
, mismatch repair protein 1