MLH1 Products
(MutL Homolog 1 (MLH1))
Categories
This gene was identified as a locus frequently mutated in hereditary nonpolyposis colon cancer (HNPCC). It is a human homolog of the E. coli DNA mismatch repair gene mutL, consistent with the characteristic alterations in microsatellite sequences (RER+phenotype) found in HNPCC. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional transcript variants have been described, but their full-length natures have not been determined.[provided by RefSeq, Nov 2009].
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Featured MLH1 Categories
MLH1 Antibodies
High quality antibodies with extensive validation data.
MLH1 ELISA Kits
Reliable ELISA kits for a wide range of species.
MLH1 Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended MLH1 Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, ELISA, FACS, ICC
Validations
- (6)
Cat. No.
ABIN7193525
Quantity
0.1 mg
Datasheet
Datasheet
Reactivity
Human
Application
WB, ELISA, IHC, FACS
Validations
- (7)
Cat. No.
ABIN7193587
Quantity
0.1 mg
Datasheet
Datasheet
Reactivity
Human
Application
WB, ELISA, IF, IHC (p), PLA
Validations
- (7)
Cat. No.
ABIN561826
Quantity
100 μg
Datasheet
Datasheet
Recommended MLH1 ELISA Kits
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6957921
Quantity
96 tests
Datasheet
Datasheet
Recommended MLH1 Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
- (1)
Cat. No.
ABIN7124036
Quantity
50 μg
Datasheet
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1311006
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1311004
Quantity
10 μg
Datasheet
Datasheet
Latest Publications for our MLH1 products
: "Integrated Proteomic and Transcriptomic Analysis Reveals Long Noncoding RNA HOX Transcript Antisense Intergenic RNA (HOTAIR) Promotes Hepatocellular Carcinoma Cell Proliferation by Regulating Opioid ..." in: Molecular & cellular proteomics : MCP, Vol. 17, Issue 1, pp. 146-159, (2019) (PubMed).: "miRNA-148b regulates radioresistance in non-small lung cancer cells via regulation of MutL homologue 1." in: Bioscience reports, Vol. 36, Issue 3, (2016) (PubMed).
: "Modulation of mismatch repair and genomic stability by miR-155. ..." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 107, Issue 15, pp. 6982-7, (2010) (PubMed).
: "Nuclear overexpression of mitotic regulatory proteins in biliary tract cancer: correlation with clinicopathologic features and patient survival." in: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, Vol. 18, Issue 2, pp. 417-23, (2009) (PubMed).
: "High-dose rapid and standard induction chemotherapy for patients aged over 1 year with stage 4 neuroblastoma: a randomised trial." in: The lancet oncology, Vol. 9, Issue 3, pp. 247-56, (2008) (PubMed).
: "Gene-related cancer spectrum in families with hereditary non-polyposis colorectal cancer (HNPCC)." in: Familial cancer, Vol. 7, Issue 2, pp. 163-72, (2008) (PubMed).
: "CXCR6 is expressed on T cells in both T helper type 1 (Th1) inflammation and allergen-induced Th2 lung inflammation but is only a weak mediator of chemotaxis." in: Immunology, Vol. 121, Issue 4, pp. 555-64, (2007) (PubMed).
: "A novel role for DNA mismatch repair and the autophagic processing of chemotherapy drugs in human tumor cells." in: Autophagy, Vol. 3, Issue 4, pp. 368-70, (2007) (PubMed).
: "Involvement of mouse Mlh1 in DNA mismatch repair and meiotic crossing over." in: Nature genetics, Vol. 13, Issue 3, pp. 336-42, (1996) (PubMed).
: "Restoration of mismatch repair to nuclear extracts of H6 colorectal tumor cells by a heterodimer of human MutL homologs." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 92, Issue 6, pp. 1950-4, (1995) (PubMed).
Synonyms and alternative names related to MLH1
mutL homolog 1 (MLH1), CG11482 gene product from transcript CG11482-RB (Mlh1), mutL homolog 1 S homeolog (mlh1.S), mutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli) (mlh1), DNA mismatch repair protein Mlh1 (LOC588545), mutL homolog 1 (mlh1), mutL homolog 1 (Mlh1), 1110035C23Rik, AI317206, AI325952, AI561766, CG11482, COCA2, Dmel\\CG11482, dmlh-1, dmlh1, FCC2, hMLH1, HNPCC, HNPCC2, LOC100232198, MLH1, zgc:66301Protein level used designations for MLH1
- MutL protein homolog 1
- CG11482-PA
- CG11482-PB
- Mlh1-PA
- Mlh1-PB
- DNA mismatch repair protein Mlh1
- mutL-like protein 1
- mutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli)
- DNA mismatch repair protein Mlh1-like
- colon cancer, nonpolyposis type 2
- mutL protein homolog 1
- mismatch repair protein 1
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