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Browse our MUS81 Proteins (MUS81)

Full name:
MUS81 Endonuclease Homolog (S. Cerevisiae) Proteins (MUS81)
On are 6 MUS81 Endonuclease Homolog (S. Cerevisiae) (MUS81) Proteins from 4 different suppliers available. Additionally we are shipping MUS81 Antibodies (41) and many more products for this protein. A total of 50 MUS81 products are currently listed.
1200008A18Rik, AI182501, ARABIDOPSIS THALIANA MMS AND UV SENSITIVE 81, ATMUS81, AW045863, CG3026, Dmel\\CG3026, EG:BACR7A4.16, F6I18.220, F6I18_220, GB15332, MMS AND UV SENSITIVE 81, MUS81, slx3, wu:fc26g01, zgc:66489, zgc:91801
list all proteins Gene Name GeneID UniProt
MUS81 71711 Q91ZJ0
MUS81 80198 Q96NY9
MUS81 293678 Q4KM32

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MUS81 Proteins (MUS81) by Origin

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More Proteins for MUS81 Interaction Partners

Fruit Fly (Drosophila melanogaster) MUS81 Endonuclease Homolog (S. Cerevisiae) (MUS81) interaction partners

  1. spontaneous mitotic crossovers that occur when FANCM is missing are dependent on MUS312 and either MUS81 or SLX1.

  2. did not find any role for MUS81-MMS4 in meiotic crossing over

Arabidopsis thaliana MUS81 Endonuclease Homolog (S. Cerevisiae) (MUS81) interaction partners

  1. SEND1 has at most a minor role in resolution of the Holliday junction but acts as an essential backup to MUS81 for resolution of toxic replication structures to ensure genome stability and to maintain telomere integrity.

  2. Data show that DNA polymerase zeta catalytic subunit REV3 cooperates with ATP-dependent DNA helicase RECQ4A and e ndonuclease MUS81 to repair DNA interstrand cross links.

  3. RECQ4A and MUS81 define RAD5A-independent pathways of DNA repair. RECQ4A and MUS81 act in parallel pathways presumably to resolve replication-associated DNA intermediates.

  4. The role of AtMUS81 in meiotic and mitotic recombination.

  5. AtMUS81 is involved in a secondary subset of meiotic crossovers that are interference insensitive.

  6. The role of MUS81 in the reproduction and growth of A. thaliana, via its expression and metabolism during meiosis, is reported.

  7. Both MUS81-EME1 (show EME1 Proteins) endonuclease complexes are involved in DNA recombination and repair processes in Arabidopsis.

Mouse (Murine) MUS81 Endonuclease Homolog (S. Cerevisiae) (MUS81) interaction partners

  1. Mus81 knockdown improves the chemosensitivity of HCC (show FAM126A Proteins) cells by inducing S-phase arrest and promoting apoptosis through CHK1 (show CHEK1 Proteins) pathway, suggesting Mus81 as a novel therapeutic target for HCC (show FAM126A Proteins).

  2. Using mice deficient in both Mus81 and the FA pathway protein FancC (show FANCC Proteins), we show both proteins cooperate in parallel pathways, as concomitant loss of FancC (show FANCC Proteins) and Mus81 triggered cell-type-specific proliferation arrest, apoptosis and DNA damage accumulation in utero.

  3. Data indicate that SLX1 and MUS81-EME1 nucleases act together to resolve Holliday junctions (HJs) in a manner that requires tethering to SLX4.

  4. FBH1 helicase activity is required to eliminate cells with excessive replication stress through the generation of MUS81-induced DNA double-strand breaks.

  5. data indicate that an important role for Chk2 (show CHEK2 Proteins) is maintaining lymphocyte development and that dual inactivation of Chk2 (show CHEK2 Proteins) and Mus81 remarkably inhibits cancer

  6. studies demonstrate a critical role for the proper biallelic expression of the mammalian Mus81 in the maintenance of genomic integrity and tumor suppression

  7. Mus81 acts at a late step in the repair of cross-link-induced lesions

  8. Mus81-Eme1 (show EME1 Proteins)- and Rad54 (show RAD54L Proteins)-mediated homologous recombination are involved in the same DNA replication-dependent interstrand crosslinks repair pathway

  9. Data suggest that Mus81 suppresses chromosomal instability by converting potentially detrimental replication-associated DNA structures into intermediates that are more amenable to DNA repair.

  10. Analysis of meiotic progression in Mus81-nullizygous mice, and our results implicate the MUS81 pathway as a regulator of crossover frequency and placement in mammals.

Human MUS81 Endonuclease Homolog (S. Cerevisiae) (MUS81) interaction partners

  1. Avoiding damage formation through invalidation of Mus81-Eme2 (show EME2 Proteins) and Mre11 (show MRE11A Proteins), or preventing damage signaling by turning off the ATM (show ATM Proteins) pathway, suppresses the replication phenotypes of Chk1 (show CHEK1 Proteins)-deficient cells.

  2. Mus81 knockdown improves the chemosensitivity of HCC (show FAM126A Proteins) cells by inducing S-phase arrest and promoting apoptosis through CHK1 (show CHEK1 Proteins) pathway, suggesting Mus81 as a novel therapeutic target for HCC (show FAM126A Proteins).

  3. Mus81 regulates the rate of DNA replication during normal growth by promoting replication fork progression while reducing the frequency of replication initiation events.

  4. Identification and characterization of MUS81 point mutations that abolish interaction with the SLX4 scaffold protein.MUS81 function in DNA interstrand crosslinks repair requires interaction with SLX4.

  5. The data highlight the importance of Mus81 and Blm in DNA double-strand repair pathways, fertility, development and cancer.

  6. Authors confirmed that HIV-1 Vpr induces degradation of Mus81 although, surprisingly, degradation is independent and genetically separable from Vprs ability to induce G2 arrest.

  7. Results define distinct and temporal roles for MUS81-EME1 (show EME1 Proteins) and MUS81-EME2 (show EME2 Proteins) in the maintenance of genome stability.

  8. Our findings reveal a novel RAD52 (show RAD52 Proteins)/MUS81-dependent mechanism that promotes cell viability and genome integrity in checkpoint-deficient cells, and disclose the involvement of MUS81 to multiple processes after replication stress

  9. While Mus81-Eme1 (show EME1 Proteins) shares several common features with members of the 5' flap (show ALOX5AP Proteins) nuclease (show DCLRE1C Proteins) family, the combined structural, biochemical, and biophysical analyses explain why Mus81-Eme1 (show EME1 Proteins) preferentially cleaves 3' flap (show ALOX5AP Proteins) DNA substrates with 5' nicked ends.

  10. In vivo HJ resolution depends on both SLX4-associated MUS81-EME1 and SLX1, suggesting that they are acting in concert in the context of SLX4.

MUS81 Protein Profile

Protein Summary

Interacts with EME1 and EME2 to form a DNA structure- specific endonuclease with substrate preference for branched DNA structures with a 5'-end at the branch nick. Typical substrates include 3'-flap structures, replication forks and nicked Holliday junctions. May be required in mitosis for the processing of stalled or collapsed replication forks.

Alternative names and synonyms associated with MUS81

  • CG3026 gene product from transcript CG3026-RA (mus81)
  • MUS81 endonuclease homolog (S. cerevisiae) (MUS81)
  • MUS81 structure-specific endonuclease subunit (mus81)
  • mus81 protein (mus81)
  • crossover junction endonuclease MUS81 (MUS81)
  • Mus81p (MUS81)
  • Holliday junction resolvase subunit Mus81 (mus81)
  • MUS81 protein (mus81)
  • MUS81 endonuclease homolog (yeast) (Mus81)
  • MUS81 endonuclease homolog (yeast) (mus81)
  • MUS81 structure-specific endonuclease subunit (MUS81)
  • MUS81 structure-specific endonuclease subunit (Mus81)
  • similar to S. cerevisiae MUS81p (YDR386W) which is part of an endonuclease involved in repair of damaged DNA replication forks (MUS81)
  • 1200008A18Rik protein
  • AI182501 protein
  • ATMUS81 protein
  • AW045863 protein
  • CG3026 protein
  • Dmel\\CG3026 protein
  • EG:BACR7A4.16 protein
  • F6I18.220 protein
  • F6I18_220 protein
  • GB15332 protein
  • MMS AND UV SENSITIVE 81 protein
  • MUS81 protein
  • slx3 protein
  • wu:fc26g01 protein
  • zgc:66489 protein
  • zgc:91801 protein

Protein level used designations for MUS81

CG3026-PA , mus81-PA , crossover junction endonuclease MUS81 , MUS81 endonuclease homolog (S. cerevisiae) , MUS81 endonuclease homolog , MUS81 protein , crossover junction endonuclease MUS81-like , SLX3 structure-specific endonuclease subunit homolog , hypothetical protein

31044 Drosophila melanogaster
466667 Pan troglodytes
476021 Canis lupus familiaris
496413 Xenopus (Silurana) tropicalis
725951 Apis mellifera
829211 Arabidopsis thaliana
851994 Saccharomyces cerevisiae S288c
2539004 Schizosaccharomyces pombe 972h-
10804405 Sordaria macrospora k-hell
100029893 Monodelphis domestica
100051745 Equus caballus
100459560 Pongo abelii
100464481 Ailuropoda melanoleuca
100511000 Sus scrofa
100590455 Nomascus leucogenys
71711 Mus musculus
406839 Danio rerio
80198 Homo sapiens
293678 Rattus norvegicus
3647146 Candida albicans SC5314
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