Browse our Nonhomologous End-Joining Factor 1 Proteins (NHEJ1)

On are 7 Nonhomologous End-Joining Factor 1 (NHEJ1) Proteins from 5 different suppliers available. Additionally we are shipping Nonhomologous End-Joining Factor 1 Antibodies (94) and Nonhomologous End-Joining Factor 1 Kits (3) and many more products for this protein. A total of 110 Nonhomologous End-Joining Factor 1 products are currently listed.
1700029B21Rik, cernunnos, NHEJ1, XLF, zgc:85657
list all proteins Gene Name GeneID UniProt
NHEJ1 79840 Q9H9Q4
NHEJ1 75570 Q3KNJ2
NHEJ1 363251 Q6AYI4

Nonhomologous End-Joining Factor 1 Proteins (NHEJ1) by Origin

More Proteins for Nonhomologous End-Joining Factor 1 Interaction Partners

Human Nonhomologous End-Joining Factor 1 (NHEJ1) interaction partners

  1. XLF has an important role during V(D)J recombination.

  2. using dual- and quadruple-trap optical tweezers combined with fluorescence microscopy, we show how human XRCC4 (show XRCC4 Proteins), XLF and XRCC4 (show XRCC4 Proteins)-XLF complexes interact with DNA in real time

  3. The data suggest that XLF has multiple functions in DNA repair, and they offer potential explanations for the pleiotropic phenotypes associated with XLF deficiency.

  4. PC4 (show IFRD1 Proteins) protects esophageal squamous cell carcinoma cells from IR-induced death by enhancing the nonhomologous end joining-promoting activity of XLF.

  5. Phosphorylation of XLF impairs non-homologous end-joining DNA repair.

  6. Werner syndrome protein positively regulates XRCC4-like factor transcription.

  7. Human XLF is a non-essential, but critical, classic non-homologous end-joining -repair factor.

  8. An induced pluripotent stem cell (iPSC) model of XLF deficiency, which accurately replicates the double-strand break repair deficiency observed in XLF syndrome patients, is reported.

  9. Data indicate that Ku70 (show XRCC6 Proteins)/Ku80 (show XRCC5 Proteins) facilitates the cooperative binding of multiple XRCC4 (show XRCC4 Proteins)/Ligase IV (XL) and XLF molecules to DNA.

  10. XRCC4 (show XRCC4 Proteins) and XLF form long helical protein filaments suitable for DNA end protection and alignment to facilitate DNA double strand break repair. (Review)

Mouse (Murine) Nonhomologous End-Joining Factor 1 (NHEJ1) interaction partners

  1. XLF has an important role during V(D)J recombination.

  2. PAXX and XLF proteins may have redundant functions during Non-homologous end joining.

  3. Paxx/Xlf double-knockout mice display embryonic lethality associated with genomic instability, cell death in the central nervous system, and an almost complete block in lymphogenesis

  4. These results reveal an unanticipated functional interplay between the RAG complex and XLF in repairing RAG-induced DNA breaks and maintaining genome integrity during antigen receptor gene assembly.

  5. XLF-deficient mice recapitulate the age-dependent lymphocytopenia of patients.

  6. XLF functionally overlaps with DNA-PKcs in normal development, promotion of genomic stability in fibroblasts, and in IgH class switch recombination in mature B cells.

  7. Cernunnos deficiency results in chronic activation of the DNA damage response, P53 (show TP53 Proteins)-driven upregulation of proapoptotic factors, leading to decreased thymocyte viability and a qualitative alteration of the T cell repertoire in both humans and mice.

  8. XLF repair protein and 53BP1 (show TP53BP1 Proteins) DNA damage response factor have overlapping functions in end joining and lymphocyte development

  9. find that combined XLF/53BP1 (show TP53BP1 Proteins) deficiency in mice severely impairs C-NHEJ, V(D)J recombination, and lymphocyte development while also leading to general genomic instability and growth defects

  10. XLF, ATM and H2AX all have fundamental roles in processing and joining DNA ends during V(D)J recombination, but that these roles have been masked by unanticipated functional redundancies

Nonhomologous End-Joining Factor 1 (NHEJ1) Protein Profile

Protein Summary

Double-strand breaks in DNA result from genotoxic stresses and are among the most damaging of DNA lesions. This gene encodes a DNA repair factor essential for the nonhomologous end-joining pathway, which preferentially mediates repair of double-stranded breaks. Mutations in this gene cause different kinds of severe combined immunodeficiency disorders.

Alternative names and synonyms associated with Nonhomologous End-Joining Factor 1 (NHEJ1)

  • nonhomologous end-joining factor 1 (NHEJ1)
  • nonhomologous end-joining factor 1 (nhej1)
  • nonhomologous end-joining factor 1 (LOC100353092)
  • nonhomologous end-joining factor 1 (Nhej1)
  • 1700029B21Rik protein
  • cernunnos protein
  • NHEJ1 protein
  • XLF protein
  • zgc:85657 protein

Protein level used designations for NHEJ1

nonhomologous end-joining factor 1 , non-homologous end-joining factor 1 , XRCC4-like factor , protein cernunnos

424205 Gallus gallus
445871 Xenopus laevis
509157 Bos taurus
742646 Pan troglodytes
100145147 Xenopus (Silurana) tropicalis
100153546 Sus scrofa
100353092 Oryctolagus cuniculus
100581628 Nomascus leucogenys
406593 Danio rerio
79840 Homo sapiens
75570 Mus musculus
363251 Rattus norvegicus
610570 Canis lupus familiaris
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