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Germline PALB2 mutation was found in patients with hereditary and sporadic gastric cancer.
PALB2 is involved in BC risk.
we describe a genetic approach to examine the functional significance of the interaction between BRCA2 (show BRCA2 Proteins) and PALB2 by generating a knock-in mouse model of Brca2 (show BRCA2 Proteins) carrying a single amino acid change (Gly25Arg, Brca2G25R) that disrupts this interaction. In addition, we have combined Brca2G25R homozygosity as well as hemizygosity with Palb2 and Trp53 (show TP53 Proteins) heterozygosity .
Results identified novel intronic mutations in PALB2 gene associated with early-onset breast cancer patients from Turkey. PABL2 mutations accounted for 4.03 % in BRCA1/2-negative Turkish patients.
rs120963 and rs249954 of the PALB2 gene are associated with increased breast cancer risk, and the association of rs249935 with breast cancer risk may be modified by the tumor pathological characteristics.
PALB2 mutations are associated with susceptibility to Pancreatic ductal adenocarcinoma in the Czech Republic.
PALB2 germline mutations are associated with breast and/or ovarian cancer.
87 out of 91 (95.6%) primary tumors were positive for PALB2 expression, as checked at the mRNA level.
PALB2 mutations account for a small, but not negligible, proportion of patients with hereditary predisposition to breast cancer in the Xinjing region of China.
a foundation for the formation and bioactivity of the G-quadruplex in the promoter region of PALB2 gene
results underscore the in vivo importance of the PALB2-BRCA1 complex formation in DSB repair and male meiosis
Palb2 synergizes with Trp53 (show TP53 Proteins) to suppress mammary tumor formation in a model of inherited breast cancer.
A key function for PALB2 is to interact with and to build up appropriate communication between BRCA1 (show BRCA1 Proteins) and BRCA2 (show BRCA2 Proteins).
This gene encodes a protein that may function in tumor suppression. This protein binds to and colocalizes with the breast cancer 2 early onset protein (BRCA2) in nuclear foci and likely permits the stable intranuclear localization and accumulation of BRCA2.
partner and localizer of BRCA2
, Fanconi N
, Fanconi anemia
, complementation group N
, partner and localizer of BRCA2-like