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PALB2 mutations are associated with susceptibility to Pancreatic ductal adenocarcinoma in the Czech Republic.
PALB2 germline mutations are associated with breast and/or ovarian cancer.
87 out of 91 (95.6%) primary tumors were positive for PALB2 expression, as checked at the mRNA level.
PALB2 mutations account for a small, but not negligible, proportion of patients with hereditary predisposition to breast cancer in the Xinjing region of China.
a foundation for the formation and bioactivity of the G-quadruplex in the promoter region of PALB2 gene
PALB2 mutations make a small contribution to the heritable breast cancer susceptibility in French population.
Although patient cells were unable to form Rad51 (show RAD51 Proteins) foci following exposure to either DNA damaging agent, U2OS cells, in which the mutant PALB2 with in frame skip of exon 6 was induced, did show recruitment of Rad51 (show RAD51 Proteins) to foci following damage.
The aim of this study was to determine the frequency and spectrum of germline mutations in BRCA1, BRCA2 and PALB2 and to evaluate the presence of the CHEK2 c.1100delC allele in these patients.
PALB2 Mutation is associated with Breast Cancer.
Novel PALB2 mutation was found in a cohort of Italian breast cancer patients.
results underscore the in vivo importance of the PALB2-BRCA1 complex formation in DSB repair and male meiosis
Palb2 synergizes with Trp53 (show TP53 Proteins) to suppress mammary tumor formation in a model of inherited breast cancer.
A key function for PALB2 is to interact with and to build up appropriate communication between BRCA1 (show BRCA1 Proteins) and BRCA2 (show BRCA2 Proteins).
This gene encodes a protein that may function in tumor suppression. This protein binds to and colocalizes with the breast cancer 2 early onset protein (BRCA2) in nuclear foci and likely permits the stable intranuclear localization and accumulation of BRCA2.
partner and localizer of BRCA2
, Fanconi N
, Fanconi anemia
, complementation group N
, partner and localizer of BRCA2-like