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Browse our PALB2 Proteins (PALB2)

Full name:
Partner and Localizer of BRCA2 Proteins (PALB2)
On are 3 Partner and Localizer of BRCA2 (PALB2) Proteins from 2 different suppliers available. Additionally we are shipping PALB2 Antibodies (48) and PALB2 Kits (2) and many more products for this protein. A total of 59 PALB2 products are currently listed.
4732427B05, BC066140, FANCN, PALB2, PNCA3, RGD1304759, si:ch211-14k19.9
list all proteins Gene Name GeneID UniProt
PALB2 79728 Q86YC2
PALB2 233826 Q3U0P1
PALB2 293452  

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PALB2 Proteins (PALB2) by Origin

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More Proteins for PALB2 Interaction Partners

Human Partner and Localizer of BRCA2 (PALB2) interaction partners

  1. PALB2 mutations make a small contribution to the heritable breast cancer susceptibility in French population.

  2. Although patient cells were unable to form Rad51 (show RAD51 Proteins) foci following exposure to either DNA damaging agent, U2OS cells, in which the mutant PALB2 with in frame skip of exon 6 was induced, did show recruitment of Rad51 (show RAD51 Proteins) to foci following damage.

  3. The aim of this study was to determine the frequency and spectrum of germline mutations in BRCA1, BRCA2 and PALB2 and to evaluate the presence of the CHEK2 c.1100delC allele in these patients.

  4. PALB2 Mutation is associated with Breast Cancer.

  5. Novel PALB2 mutation was found in a cohort of Italian breast cancer patients.

  6. Germ-line DNA samples from 727 unrelated probands with positive family history (521 met criteria for familial pancreatic cancer) were tested for mutations in BRCA1 and BRCA2, PALB2, and CDKN2A.

  7. The truncating variants in PALB2 as high-penetrance breast cancer susceptibility alleles.

  8. Two novel heterozygous mutations predicted to alter the function of PALB2 were identified (c.2014G>C, p.E672Q and c.2993G>A, p.G998E). Notably, both of these mutations co-existed in BRCA1 and BRCA2 (show BRCA2 Proteins) families

  9. Truncating PALB2 mutations were detected in families with breast cancer negative for which a BRCA1 or BRCA2 (show BRCA2 Proteins) mutation has not been found.

  10. Our results suggest that PALB2 c.1676A > G and c.2993C > T play roles in BC risk in women with a strong family history of BC.

Mouse (Murine) Partner and Localizer of BRCA2 (PALB2) interaction partners

  1. results underscore the in vivo importance of the PALB2-BRCA1 complex formation in DSB repair and male meiosis

  2. Palb2 synergizes with Trp53 (show TP53 Proteins) to suppress mammary tumor formation in a model of inherited breast cancer.

  3. A key function for PALB2 is to interact with and to build up appropriate communication between BRCA1 (show BRCA1 Proteins) and BRCA2 (show BRCA2 Proteins).

PALB2 Protein Profile

Protein Summary

This gene encodes a protein that may function in tumor suppression. This protein binds to and colocalizes with the breast cancer 2 early onset protein (BRCA2) in nuclear foci and likely permits the stable intranuclear localization and accumulation of BRCA2.

Alternative names and synonyms associated with PALB2

  • partner and localizer of BRCA2 (PALB2)
  • partner and localizer of BRCA2 (palb2)
  • partner and localizer of BRCA2 (LOC100356031)
  • partner and localizer of BRCA2 (Palb2)
  • 4732427B05 protein
  • BC066140 protein
  • FANCN protein
  • PALB2 protein
  • PNCA3 protein
  • RGD1304759 protein
  • si:ch211-14k19.9 protein

Protein level used designations for PALB2

partner and localizer of BRCA2 , Fanconi N , Fanconi anemia , complementation group N , partner and localizer of BRCA2-like

416572 Gallus gallus
453988 Pan troglodytes
558923 Danio rerio
608527 Canis lupus familiaris
700843 Macaca mulatta
733293 Xenopus laevis
100069097 Equus caballus
100356031 Oryctolagus cuniculus
100408318 Callithrix jacchus
100436331 Pongo abelii
100479015 Ailuropoda melanoleuca
100523630 Sus scrofa
100593417 Nomascus leucogenys
79728 Homo sapiens
233826 Mus musculus
293452 Rattus norvegicus
507620 Bos taurus
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