Browse our PALB2 Proteins (PALB2)

Full name:
Partner and Localizer of BRCA2 Proteins (PALB2)
On are 3 Partner and Localizer of BRCA2 (PALB2) Proteins from 2 different suppliers available. Additionally we are shipping PALB2 Antibodies (70) and PALB2 Kits (2) and many more products for this protein. A total of 81 PALB2 products are currently listed.
4732427B05, BC066140, FANCN, PALB2, PNCA3, RGD1304759, si:ch211-14k19.9
list all proteins Gene Name GeneID UniProt
PALB2 79728 Q86YC2
PALB2 233826 Q3U0P1
PALB2 293452  

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PALB2 Proteins (PALB2) by Origin

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More Proteins for PALB2 Interaction Partners

Human Partner and Localizer of BRCA2 (PALB2) interaction partners

  1. Prevalence of germline PALB2 mutations among women with epithelial ovarian cancer in Ontario

  2. inherited pathogenic variants in PALB2 were associated with high risks of breast cancer

  3. Findings establish L35P as the first pathogenic missense mutation in PALB2 and directly demonstrate the requirement of the PALB2-BRCA1 interaction for breast cancer suppression.

  4. In this paper, we describe an extension to the BOADICEA model to incorporate the effects of intermediate risk variants for breast cancer, specifically loss of function mutations in the three genes for which the evidence for association is clearest and the risk estimates most precise: PALB2, CHEK2 (show CHEK2 Proteins) and ATM (show ATM Proteins)

  5. Data show an increase of error-prone single-strand annealing (SSA (show TRIM21 Proteins)) and microhomology-mediated end-joining (MMEJ) in the PALB2 (partner and localizer of BRCA2) c.1592delT mutation carriers.

  6. Studies suggest that people with high risk of breast cancer and negative BRCA1/BRCA2 (show BRCA2 Proteins) should be tested for PALB2 mutations.

  7. PALB2 rare variants were associated with an increased risk of breast cancer.

  8. our findings highlight a critical importance of PALB2 phosphorylation as a novel regulatory step in genome maintenance after genotoxic stress.

  9. identification of a hidden nuclear export signal (NES (show NES Proteins)) within the WD40 domain (show DCAF12L2 Proteins) of PALB2 and found that the W1038X truncation leads to the exposure of this NES (show NES Proteins) to CRM1 (show XPO1 Proteins), an export protein

  10. PALB2 mutation along with BRCA1 mutation confers chemoresistance in breast cancer.

Mouse (Murine) Partner and Localizer of BRCA2 (PALB2) interaction partners

  1. we describe a genetic approach to examine the functional significance of the interaction between BRCA2 (show BRCA2 Proteins) and PALB2 by generating a knock-in mouse model of Brca2 (show BRCA2 Proteins) carrying a single amino acid change (Gly25Arg, Brca2G25R) that disrupts this interaction. In addition, we have combined Brca2G25R homozygosity as well as hemizygosity with Palb2 and Trp53 (show TP53 Proteins) heterozygosity .

  2. results underscore the in vivo importance of the PALB2-BRCA1 complex formation in DSB repair and male meiosis

  3. Palb2 synergizes with Trp53 (show TP53 Proteins) to suppress mammary tumor formation in a model of inherited breast cancer.

  4. A key function for PALB2 is to interact with and to build up appropriate communication between BRCA1 (show BRCA1 Proteins) and BRCA2 (show BRCA2 Proteins).

PALB2 Protein Profile

Protein Summary

This gene encodes a protein that may function in tumor suppression. This protein binds to and colocalizes with the breast cancer 2 early onset protein (BRCA2) in nuclear foci and likely permits the stable intranuclear localization and accumulation of BRCA2.

Alternative names and synonyms associated with PALB2

  • partner and localizer of BRCA2 (PALB2)
  • partner and localizer of BRCA2 (palb2)
  • partner and localizer of BRCA2 (LOC100356031)
  • partner and localizer of BRCA2 (Palb2)
  • 4732427B05 protein
  • BC066140 protein
  • FANCN protein
  • PALB2 protein
  • PNCA3 protein
  • RGD1304759 protein
  • si:ch211-14k19.9 protein

Protein level used designations for PALB2

partner and localizer of BRCA2 , Fanconi N , Fanconi anemia , complementation group N , partner and localizer of BRCA2-like

416572 Gallus gallus
453988 Pan troglodytes
558923 Danio rerio
608527 Canis lupus familiaris
700843 Macaca mulatta
733293 Xenopus laevis
100069097 Equus caballus
100356031 Oryctolagus cuniculus
100408318 Callithrix jacchus
100436331 Pongo abelii
100479015 Ailuropoda melanoleuca
100523630 Sus scrofa
100593417 Nomascus leucogenys
79728 Homo sapiens
233826 Mus musculus
293452 Rattus norvegicus
507620 Bos taurus
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