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Browse our PALB2 Proteins (PALB2)

Full name:
Partner and Localizer of BRCA2 Proteins (PALB2)
On www.antibodies-online.com are 3 Partner and Localizer of BRCA2 (PALB2) Proteins from 2 different suppliers available. Additionally we are shipping PALB2 Antibodies (68) and PALB2 Kits (2) and many more products for this protein. A total of 79 PALB2 products are currently listed.
Synonyms:
4732427B05, BC066140, FANCN, PALB2, PNCA3, RGD1304759, si:ch211-14k19.9
list all proteins Gene Name GeneID UniProt
PALB2 79728 Q86YC2
PALB2 233826 Q3U0P1
PALB2 293452  

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PALB2 Proteins (PALB2) by Origin

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More Proteins for PALB2 Interaction Partners

Human Partner and Localizer of BRCA2 (PALB2) interaction partners

  1. Germline PALB2 mutation was found in patients with hereditary and sporadic gastric cancer.

  2. PALB2 is involved in BC risk.

  3. we describe a genetic approach to examine the functional significance of the interaction between BRCA2 (show BRCA2 Proteins) and PALB2 by generating a knock-in mouse model of Brca2 (show BRCA2 Proteins) carrying a single amino acid change (Gly25Arg, Brca2G25R) that disrupts this interaction. In addition, we have combined Brca2G25R homozygosity as well as hemizygosity with Palb2 and Trp53 (show TP53 Proteins) heterozygosity .

  4. Results identified novel intronic mutations in PALB2 gene associated with early-onset breast cancer patients from Turkey. PABL2 mutations accounted for 4.03 % in BRCA1/2-negative Turkish patients.

  5. rs120963 and rs249954 of the PALB2 gene are associated with increased breast cancer risk, and the association of rs249935 with breast cancer risk may be modified by the tumor pathological characteristics.

  6. PALB2 mutations are associated with susceptibility to Pancreatic ductal adenocarcinoma in the Czech Republic.

  7. PALB2 germline mutations are associated with breast and/or ovarian cancer.

  8. 87 out of 91 (95.6%) primary tumors were positive for PALB2 expression, as checked at the mRNA level.

  9. PALB2 mutations account for a small, but not negligible, proportion of patients with hereditary predisposition to breast cancer in the Xinjing region of China.

  10. a foundation for the formation and bioactivity of the G-quadruplex in the promoter region of PALB2 gene

Mouse (Murine) Partner and Localizer of BRCA2 (PALB2) interaction partners

  1. we describe a genetic approach to examine the functional significance of the interaction between BRCA2 (show BRCA2 Proteins) and PALB2 by generating a knock-in mouse model of Brca2 (show BRCA2 Proteins) carrying a single amino acid change (Gly25Arg, Brca2G25R) that disrupts this interaction. In addition, we have combined Brca2G25R homozygosity as well as hemizygosity with Palb2 and Trp53 (show TP53 Proteins) heterozygosity .

  2. results underscore the in vivo importance of the PALB2-BRCA1 complex formation in DSB repair and male meiosis

  3. Palb2 synergizes with Trp53 (show TP53 Proteins) to suppress mammary tumor formation in a model of inherited breast cancer.

  4. A key function for PALB2 is to interact with and to build up appropriate communication between BRCA1 (show BRCA1 Proteins) and BRCA2 (show BRCA2 Proteins).

PALB2 Protein Profile

Protein Summary

This gene encodes a protein that may function in tumor suppression. This protein binds to and colocalizes with the breast cancer 2 early onset protein (BRCA2) in nuclear foci and likely permits the stable intranuclear localization and accumulation of BRCA2.

Alternative names and synonyms associated with PALB2

  • partner and localizer of BRCA2 (PALB2)
  • partner and localizer of BRCA2 (palb2)
  • partner and localizer of BRCA2 (LOC100356031)
  • partner and localizer of BRCA2 (Palb2)
  • 4732427B05 protein
  • BC066140 protein
  • FANCN protein
  • PALB2 protein
  • PNCA3 protein
  • RGD1304759 protein
  • si:ch211-14k19.9 protein

Protein level used designations for PALB2

partner and localizer of BRCA2 , Fanconi N , Fanconi anemia , complementation group N , partner and localizer of BRCA2-like

GENE ID SPECIES
416572 Gallus gallus
453988 Pan troglodytes
558923 Danio rerio
608527 Canis lupus familiaris
700843 Macaca mulatta
733293 Xenopus laevis
100069097 Equus caballus
100356031 Oryctolagus cuniculus
100408318 Callithrix jacchus
100436331 Pongo abelii
100479015 Ailuropoda melanoleuca
100523630 Sus scrofa
100593417 Nomascus leucogenys
79728 Homo sapiens
233826 Mus musculus
293452 Rattus norvegicus
507620 Bos taurus
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