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Browse our POLB Proteins (POLB)

Full name:
Polymerase (DNA Directed), beta Proteins (POLB)
On www.antibodies-online.com are 14 Polymerase (DNA Directed), beta (POLB) Proteins from 7 different suppliers available. Additionally we are shipping POLB Antibodies (100) and POLB Kits (5) and many more products for this protein. A total of 127 POLB products are currently listed.
Synonyms:
A430088C08Rik, DDBDRAFT_0186152, DDBDRAFT_0215784, DDBDRAFT_0232376, DDB_0186152, DDB_0215784, DDB_0232376, POLB, wu:fa97a05, zgc:109924
list all proteins Gene Name GeneID UniProt
POLB 5423 P06746
POLB 18970 Q8K409
POLB 29240 P06766

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POLB Proteins (POLB) by Origin

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Top referenced POLB Proteins

  1. Human POLB Protein expressed in Escherichia coli (E. coli) - ABIN667538 : Bambara, Jessee: Properties of DNA polymerases delta and epsilon, and their roles in eukaryotic DNA replication. in Biochimica et biophysica acta 1991 (PubMed)
    Show all 2 references for ABIN667538

More Proteins for POLB Interaction Partners

Zebrafish Polymerase (DNA Directed), beta (POLB) interaction partners

  1. DNA polymerase beta is sensitive to Mn2+ and Mg2 (show MCOLN1 Proteins)+ and its optimumal pH is 9.

  2. In brief, the major differences in BER performed by early stage embryos and adults are the absence of DNA polymerase-beta, leading to predominance of replicative polymerases, in early stage embryos.

Human Polymerase (DNA Directed), beta (POLB) interaction partners

  1. Remote mutations induce functional changes in active site residues of human DNA polymerase beta.

  2. It has been concluded based on calculations and the experimental pH profile that the most likely path for the wild-type (WT) and the D256E and D256A mutants is a proton transfer (PT) to the bulk, although the WT may also use a PT to Asp (show ASIP Proteins) 256.

  3. The homozygous/heterozygous genotypes containing the African allele showed higher POLB expression than the homozygous white allele genotype (P < .001). A replication study using a GEO data set validated all 5 eQTLs and also showed a statistically significant difference in POLB expression based on genetic ancestry (P = .002).

  4. HMGB1 (show HMGB1 Proteins) stimulates activity of DNA polymerase beta on nucleosome substrates in the process of base excision repair.

  5. The results help to define the tolerance of DNA Pol beta to subtle local structural and functional alterations derived from lysine 72.

  6. HSP90 (show HSP90 Proteins) regulates DNA repair by interaction between XRCC1 (show XRCC1 Proteins) and DNA polymerase beta.

  7. Data did not detect any significant association with SNPs of APRIL, SPATA8, PDGFRA, and POLB with Systemic Lupus Erythematosus in Chinese Han Population.

  8. a substitution mutation, R152C, impairs Pol beta polymerase activity and DNA base excision repair efficiency.

  9. Data show that esophageal carcinoma (EC) cells expressing the DNA polymerase beta K167I variant to be sensitive to DNA damaging agents.

  10. Pol lambda (show POLL Proteins) can incorporate rNMPs opposite normal bases or 8-oxo-G, and with a different fidelity. Further, the incorporation of rNMPs opposite 8-oxo-G delays repair by DNA glycosylases.

Mouse (Murine) Polymerase (DNA Directed), beta (POLB) interaction partners

  1. pol beta plays an important role in bypassing a 5',8-cyclo-dA during DNA replication and repair.

  2. we show here that heterozygosity for a Y265C mutation in Polbeta, a key polymerase in the BER pathway, is enough to significantly reduce both the number of expansions seen in paternal gametes and the extent of somatic expansion in some tissues

  3. The aberrant DNA replication mediated by the PCNA (show PCNA Proteins)-DNA pol-b complex induces p53 (show TP53 Proteins)-dependent neuronal cell death

  4. Y265C POLB mutation leads to several pathologies associated with SLE and short CDR3 regions during VDJ recombination in B cells.

  5. Pol beta deficiency could enable ROS (show ROS1 Proteins) accumulation.

  6. Results show that deficiency of either DNA polymerases beta or lambda or both results in a modest but significant decrease in V region somatic hypermutation (SHM (show CNTNAP1 Proteins)) with no effect on mutation specificity, suggesting no direct role in SHM (show CNTNAP1 Proteins).

  7. Transient OGG1 (show OGG1 Proteins), APE1 (show APEX1 Proteins), PARP1 (show PARP1 Proteins) and Polbeta expression in an Alzheimer's disease mouse model.

  8. Data indicate an association of ovarian stimulation with a downregulation of mRNAs encoding the base excision repair proteins APEX1 (show APEX1 Proteins) and POLB as well as the 5-methyl-CpG-binding domain protein MBD3 (show MBD3 Proteins) in individual morula embryos.

  9. Overexpression of Pol beta could reduce oxidative damage and protect cells from hydroquinone genotoxicity.

  10. Polbeta could protect cells from apoptosis induced by hydroquinone through decrease of ROS (show ROS1 Proteins) level and depolarization of mitochondria.

POLB Protein Profile

Protein Summary

The protein encoded by this gene is a DNA polymerase involved in base excision and repair, also called gap-filling DNA synthesis. The encoded protein, acting as a monomer, is normally found in the cytoplasm, but it translocates to the nucleus upon DNA damage. Several transcript variants of this gene exist, but the full-length nature of only one has been described to date.

Alternative names and synonyms associated with POLB

  • polymerase (DNA directed), beta (polb)
  • polymerase (DNA directed), beta (POLB)
  • DNA polymerase X family protein (polB)
  • DNA polymerase beta-like (LOC100526021)
  • polymerase (DNA directed), beta (Polb)
  • A430088C08Rik protein
  • DDBDRAFT_0186152 protein
  • DDBDRAFT_0215784 protein
  • DDBDRAFT_0232376 protein
  • DDB_0186152 protein
  • DDB_0215784 protein
  • DDB_0232376 protein
  • POLB protein
  • wu:fa97a05 protein
  • zgc:109924 protein

Protein level used designations for POLB

DNA-directed DNA polymerase beta , DNA polymerase beta , polymerase (DNA directed), beta , DNA polymerase beta-like , DNA pol beta , DNA polymerase beta subunit , mutant DNA polymerase beta , Pol beta , polymerase-beta

GENE ID SPECIES
448741 Xenopus (Silurana) tropicalis
554204 Danio rerio
704801 Macaca mulatta
737210 Pan troglodytes
8624738 Dictyostelium discoideum AX4
100348691 Oryctolagus cuniculus
100393825 Callithrix jacchus
100441812 Pongo abelii
100526021 Sus scrofa
5423 Homo sapiens
614688 Bos taurus
397973 Xenopus laevis
18970 Mus musculus
29240 Rattus norvegicus
426794 Gallus gallus
494001 Canis lupus familiaris
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