Browse our POLL Proteins (POLL)

Full name:
Polymerase (DNA Directed), lambda Proteins (POLL)
On are 6 Polymerase (DNA Directed), lambda (POLL) Proteins from 4 different suppliers available. Additionally we are shipping POLL Antibodies (62) and many more products for this protein. A total of 73 POLL products are currently listed.
1110003P06Rik, AV007317, beta-n, BETAN, pol-kappa, POLKAPPA, T10O24.13, T10O24_13, wu:fe49a04, zgc:66320, zgc:77901
list all proteins Gene Name GeneID UniProt
POLL 27343 Q9UGP5
POLL 56626 Q9QXE2
Rat POLL POLL 361767 Q5RKI3

Show all synonyms

POLL Proteins (POLL) by Origin

Select your origin of interest

Top referenced POLL Proteins

  1. Human POLL Protein expressed in Escherichia coli (E. coli) - ABIN667964 : O-Wang, Kawamura, Tada, Ohmori, Kimura, Sakiyama, Tagawa: DNA polymerase kappa, implicated in spontaneous and DNA damage-induced mutagenesis, is overexpressed in lung cancer. in Cancer research 2001 (PubMed)
    Show all 2 references for 667964

More Proteins for POLL Interaction Partners

Arabidopsis thaliana Polymerase (DNA Directed), lambda (POLL) interaction partners

  1. DNA Pol lambda recognizes 8-Oxo-G on a template as a normal guanine and preferentially incorporates dCTP over dATP opposite this lesion.

Human Polymerase (DNA Directed), lambda (POLL) interaction partners

  1. T204 was identified as a main target for ATM (show ATM Proteins)/DNA-PKcs (show PRKDC Proteins) phosphorylation on human POLL, and this phosphorylation may facilitate the repair of a subset of IR-induced DSBs and the efficient POLL-mediated gap-filling during NHEJ. POLL phosphorylation might favor POLL interaction with the DNA-PK complex at DSBs.

  2. The authors demonstrate that Pol lambda has a flexible active site that can tolerate 8-oxo-dG in either the anti- or syn (show FYN Proteins)-conformation. Importantly, we show that discrimination against the pro-mutagenic syn (show FYN Proteins)-conformation occurs at the extension step and identify the residue responsible for this selectivity.

  3. Pol beta (show POLB Proteins), to a greater extent than Pol lambda can incorporate rNMPs opposite normal bases or 8-oxo-G, and with a different fidelity. Further, the incorporation of rNMPs opposite 8-oxo-G delays repair by DNA glycosylases.

  4. Fen1 (show FEN1 Proteins) significantly stimulated trinucleotide repeats expansion by Pol beta (show POLB Proteins), but not by the related enzyme Pol lambda.

  5. DNA polymerase (show POLB Proteins) lamda catalyzes lesion bypass across benzo[a]pyrene-derived DNA adducts.

  6. pol lambda is responsible for a significant fraction of Fapy.dG-induced G --> T mutations.

  7. Structural basis for the binding and incorporation of nucleotide analogs with L-stereochemistry by human DNA polymerase lambda.

  8. A specific N-terminal extension of the 8 kDa domain of DNA polymerase lambda is important for the non-homologous end joining function.

  9. Inactivation of polymerase (DNA directed) lambda lyase activity by 5'-(2-phosphoryl-1,4-dioxobutane prevents the enzyme from conducting polymerization following preincubation of the protein and DNA.

  10. The results provides evidence that DNA pol lambda is required for cell cycle progression and is functionally connected to the S phase DNA damage response machinery in cancer cells.

Mouse (Murine) Polymerase (DNA Directed), lambda (POLL) interaction partners

  1. Pol mu (show POLM Proteins) and Pol lambda play a key role in conferring on NHEJ the flexibility required for accurate and efficient repair

  2. Results show that deficiency of either DNA polymerases beta or lambda or both results in a modest but significant decrease in V region somatic hypermutation (SHM (show CNTNAP1 Proteins)) with no effect on mutation specificity, suggesting no direct role in SHM (show CNTNAP1 Proteins).

  3. both pol lambda and pol beta (show POLB Proteins) interact with the upstream DNA glycosylases for repair of alkylated and oxidized DNA bases

  4. analysis of the interaction between DNA Polymerase lambda and anticancer nucleoside analogs

  5. Hydrocephalus, situs inversus, chronic sinusitis, and male infertility in DNA polymerase lambda-deficient mice: possible implication for the pathogenesis of immotile cilia syndrome.

  6. Pol lambda is not required for normal Ig gene hypermutation.

  7. Pol lambda contributes to base excision repair in mouse fibroblast cell extract.

  8. Pol lambda protects cells against oxidative stress, and participates in oxidative DNA damage base excision repair.

  9. third hypervariable region assumes for each immunoglobulin chain, with pol lambda maintaining a large heavy chain junctional heterogeneity and pol mu (show POLM Proteins) ensuring a restricted light chain junctional variability

POLL Protein Profile

Protein Summary

This gene encodes a DNA polymerase. DNA polymerases catalyze DNA-template-directed extension of the 3'-end of a DNA strand. This particular polymerase, which is a member of the X family of DNA polymerases, likely plays a role in non-homologous end joining and other DNA repair processes. Alternatively spliced transcript variants have been described.

Alternative names and synonyms associated with POLL

  • DNA polymerase lambda subunit (AT1G10520)
  • DNA polymerase lambda (PTRG_00468)
  • polymerase (DNA directed), lambda (poll)
  • polymerase (DNA directed), lambda (POLL)
  • DNA polymerase lambda (MCYG_03796)
  • DNA polymerase lambda (ARALYDRAFT_312091)
  • DNA polymerase lambda (MGYG_02138)
  • polymerase (DNA directed), lambda (Poll)
  • 1110003P06Rik protein
  • AV007317 protein
  • beta-n protein
  • BETAN protein
  • pol-kappa protein
  • POLKAPPA protein
  • T10O24.13 protein
  • T10O24_13 protein
  • wu:fe49a04 protein
  • zgc:66320 protein
  • zgc:77901 protein

Protein level used designations for POLL

DNA polymerase lambda , DNA-directed DNA polymerase lambda , polymerase (DNA directed), lambda , DNA polymerase lambda-like , DNA polymerase beta-2 , DNA polymerase beta-N , DNA polymerase kappa , pol Lambda

837592 Arabidopsis thaliana
6339420 Pyrenophora tritici-repentis Pt-1C-BFP
406697 Danio rerio
450687 Pan troglodytes
711924 Macaca mulatta
9229614 Arthroderma otae CBS 113480
9325878 Arabidopsis lyrata subsp. lyrata
10029906 Arthroderma gypseum CBS 118893
100101731 Xenopus (Silurana) tropicalis
100458210 Pongo abelii
100471165 Ailuropoda melanoleuca
100583874 Nomascus leucogenys
27343 Homo sapiens
56626 Mus musculus
608341 Canis lupus familiaris
361767 Rattus norvegicus
423853 Gallus gallus
100153781 Sus scrofa
522307 Bos taurus
Selected quality suppliers for POLL Proteins (POLL)
Did you look for something else?