Browse our Polymerase (DNA Directed), mu Proteins (POLM)

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Polymerase (DNA Directed), mu Proteins (POLM)
On are 2 Polymerase (DNA Directed), mu (POLM) Proteins from 1 different suppliers available. Additionally we are shipping Polymerase (DNA Directed), mu Antibodies (37) and many more products for this protein. A total of 42 Polymerase (DNA Directed), mu products are currently listed.
AI462166, B230309I03Rik, POLM, Pol Mu, polmu, Tdt-N, zgc:56122
list all proteins Gene Name GeneID UniProt
POLM 27434 Q9NP87
POLM 54125 Q9JIW4
Rat POLM POLM 289757  

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Polymerase (DNA Directed), mu Proteins (POLM) by Origin

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More Proteins for Polymerase (DNA Directed), mu Interaction Partners

Zebrafish Polymerase (DNA Directed), mu (POLM) interaction partners

  1. Polmicro expression was detected not only in pro- and mesonephros, the major sites for B-lymphocyte (show AKAP17A Proteins) development, but also in ovary and testis and in all tissue preparations to a low extent.

Human Polymerase (DNA Directed), mu (POLM) interaction partners

  1. analysis of template-dependent synthesis by human polymerase mu

  2. A study of how Polmu fixes and/or orients the mobile Loop1 part of the protein in accordance with the substrate on which it is polymerizing.

  3. specific loop 1 residues contribute to Pol mu's unique ability to catalyze template-dependent NHEJ of DSBs with unpaired 3' ends

  4. evidence suggests that Polmu could be regulated in vivo by phosphorylation of the BRCT domain (Ser12/Thr21) and of Ser372, affecting the function of loop1; Polmu's most distinctive activities would be turned off at specific cell-cycle phases (S and G2), when these functions might be harmful to the cell

  5. A specific N-terminal extension of the 8 kDa domain of DNA polymerase mu is potentially implicated in the maintenance of a closed conformation throughout the catalytic cycle, and this study indicated that it could be a target of Cdk (show CDK4 Proteins) phosphorylation.

  6. The study points at human Polmicro residues His(329) and Arg(387) as responsible for regulating nucleotide expansions occurring during DNA repair transactions, either promoting or blocking, respectively, iterative polymerization.

  7. Pol mu binds to DNA through its amino-terminal and pol beta (show POLB Proteins)-like regions.

  8. DNA polymerase mu performs DNA synthesis at a AAF lesion

  9. Association of DNA polymerase mu (pol mu) with Ku and ligase IV: role for pol mu in end-joining double-strand break repair.

  10. DNA polymerase mu acts in response to several types of DNA damage with a lesion bypass mechanism

Mouse (Murine) Polymerase (DNA Directed), mu (POLM) interaction partners

  1. Pol mu and Pol lambda (show POLL Proteins) play a key role in conferring on NHEJ the flexibility required for accurate and efficient repair

  2. Polmu deficiency activates transcriptional networks that reduce constitutive apoptosis, leading to enhanced liver repair at old age.

  3. DNA polymerase mu has a role in decreased learning and brain long-term potentiation in aged mice

  4. These data point to a critical role for pol mu as a global repair player that increases the efficiency and the fidelity of non-homologous end-joining.

  5. A series of molecular-dynamics simulations with and without the incoming nucleotide in various forms, including mutant systems, based on pol mu's crystal ternary structure, were analyzed.

  6. Pol mu is not required for normal Ig gene hypermutation.

  7. Pol mu promotes accuracy during Ig kappa recombination.

  8. third hypervariable region assumes for each immunoglobulin chain, with pol lambda (show POLL Proteins) maintaining a large heavy chain junctional heterogeneity and pol mu ensuring a restricted light chain junctional variability

  9. The crystal structure of the polymerase domain of murine Pol mu bound to gapped DNA with a correct dNTP at the active site reveals substrate interactions with side chains in Pol mu that differ from other family X members.

  10. Polmu participates in the repair of early-embryo, RAG-induced double-strand breaks and subsequently may contribute to preserve the genomic stability and cellular homeostasis of lymphohematopoietic precursors during development

Polymerase (DNA Directed), mu (POLM) Protein Profile

Protein Summary

Gap-filling polymerase involved in repair of DNA double- strand breaks by non-homologous end joining (NHEJ). Participates in immunoglobulin (Ig) light chain gene rearrangement in V(D)J recombination.

Alternative names and synonyms associated with Polymerase (DNA Directed), mu (POLM)

  • polymerase (DNA directed), mu (polm)
  • polymerase (DNA directed), mu (POLM)
  • DNA polymerase mu (CC1G_09351)
  • DNA polymerase mu (VDBG_09335)
  • polymerase (DNA directed), mu (Polm)
  • AI462166 protein
  • B230309I03Rik protein
  • POLM protein
  • Pol Mu protein
  • polmu protein
  • Tdt-N protein
  • zgc:56122 protein

Protein level used designations for POLM

DNA polymerase mu , DNA-directed DNA polymerase mu , DNA-directed DNA/RNA polymerase mu , polymerase (DNA directed), mu , DNA polymerase mu-like , Pol iota , polymerase (DNA-directed), mu , terminal transferase , pol Mu

393218 Danio rerio
513780 Bos taurus
737708 Pan troglodytes
100461859 Pongo abelii
100515113 Sus scrofa
100590644 Nomascus leucogenys
6006630 Coprinopsis cinerea okayama7130
9528971 Verticillium alfalfae VaMs.102
27434 Homo sapiens
54125 Mus musculus
289757 Rattus norvegicus
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