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Browse our PRKDC (PRKDC) ELISA Kits

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Protein Kinase, DNA-Activated, Catalytic Polypeptide ELISA Kits (PRKDC)
On are 4 Protein Kinase, DNA-Activated, Catalytic Polypeptide (PRKDC) ELISA Kits from 4 different suppliers available. Additionally we are shipping PRKDC Antibodies (369) and PRKDC Proteins (4) and many more products for this protein. A total of 385 PRKDC products are currently listed.
AI326420, AU019811, DNA-PKCS, DNAPDcs, dnapk, dnpk1, DOXNPH, dxnph, hyrc, hyrc1, p350, p460, PRKDC, prkdc-A, scid, slip, xrcc7
list all ELISA KIts Gene Name GeneID UniProt
PRKDC 19090 P97313
PRKDC 5591 P78527

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PRKDC (PRKDC) ELISA Kits by Reactivity

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Mouse (Murine) Protein Kinase, DNA-Activated, Catalytic Polypeptide (PRKDC) interaction partners

  1. AIM2 (show AIM2 ELISA Kits) reduced Akt (show AKT1 ELISA Kits) activation and tumor burden in colorectal cancer models, while an Akt (show AKT1 ELISA Kits) inhibitor reduced tumor load in Aim2 (show AIM2 ELISA Kits)(-/-) mice

  2. PRKDC proteins that mediate non-homologous end joining have been identified as TRIP13 (show TRIP13 ELISA Kits) binding partners in head and neck cancer.

  3. NR5A1 (show NR5A1 ELISA Kits) prevents centriole splitting by inhibiting centrosomal DNA-PK activation and beta-catenin (show CTNNB1 ELISA Kits) accumulation

  4. Results show that DNA-PKcs functions as a selective modulator of transcriptional networks that induce cell migration, invasion, and metastasis of prostate cancer cells.

  5. These experiments define a novel requirement for 53BP1 (show TP53BP1 ELISA Kits) in the fusions of DNA-PKcs-deficient telomeres throughout the cell cycle.

  6. data suggest that DNA-PKcs-SIN1 (show MAPKAP1 ELISA Kits) complexation-mediated Akt (show AKT1 ELISA Kits) activation (Ser (show SIGLEC1 ELISA Kits)-473 phosphorylation) is required for mouse osteoblast differentiation

  7. Activated platelets accumulate in the brain rescue apoptotic neuron cells via activation of EGFR and DNA-dependent protein kinase.

  8. DNA-PK and ATM (show ATM ELISA Kits) acts in parallel upstream of XRCC4 (show XRCC4 ELISA Kits), regulating through phosphorylation

  9. DNA-PKcs is the molecular switch that coordinates end-processing and end-ligation at the DNAends through differential phosphorylations.

  10. DNA-PK/Chk2 (show CHEK2 ELISA Kits) signaling induces centrosome amplification upon long-term HU treatment, therefore increasing our insight into tumor recurrence after initial chemotherapy.

Human Protein Kinase, DNA-Activated, Catalytic Polypeptide (PRKDC) interaction partners

  1. A significantly different distribution was found in the frequency of PRKDC (rs7003908) genotype between the ESCC group and controls. Individuals homozygous for the C allele had a significant (3.185-fold) increased risk of ESCC.

  2. Transient knockdown of PRKDC reduced cell proliferation/survival in HCT116 and DLD1, but not FHC (show FTH1 ELISA Kits) cells. PRKDC down-regulation induced apoptosis partially through inhibiting AKT (show AKT1 ELISA Kits) activation, and sensitized HCT116 cells to chemotherapeutic agents

  3. DNA methylation (show HELLS ELISA Kits) modification plays an important role to regulate the gene expression of XRCC5 (show XRCC5 ELISA Kits) and XRCC7, from the results that the gene methylation level of the glioma group is higher than that of the normal group

  4. The ends are then closely aligned, which requires XLF (show NHEJ1 ELISA Kits), a non-catalytic function of XRCC4 (show XRCC4 ELISA Kits)-LIG4 (show LIG4 ELISA Kits), and DNA-PK activity

  5. suggested that DNA-PK and PARP (show COL11A2 ELISA Kits)-dependent recruitment of XRCC1 (show XRCC1 ELISA Kits) is necessary to effectively protect, repair, and restart stalled replication forks, providing new insight into how genomic stability is preserved

  6. Data show that inhibition of DNA-dependent protein kinase catalytic subunit (DNA-PK) prevents type I DNA topoisomerase (Top1 (show TOP1 ELISA Kits)) degradation and proteasome activity in camptothecin (CPT (show CHPT1 ELISA Kits))-treated quiescent WI38 cells.

  7. These results provide new evidence linking cell cycle to bystander responses and demonstrate that DNA-PKcs and ATM (show ATM ELISA Kits) are two associated factors in co-regulating G2-M phase-related bystander effects.

  8. CD133 and DNAPK regulate MDR1 via the PI3K (show PIK3CA ELISA Kits)- or Akt (show AKT1 ELISA Kits)-NF-kappaB (show NFKB1 ELISA Kits) pathway in multidrug-resistant glioblastoma cells.

  9. c-Myc (show MYC ELISA Kits) protein functions in the process of DNA double-strand break repair, at least partially, through affecting the ATM (show ATM ELISA Kits) phosphorylation and DNA-PKcs kinase activity.

  10. DNA-PKcs has a role in cancer metastasis through regulation of secreted proteins involved in migration and invasion

Xenopus laevis Protein Kinase, DNA-Activated, Catalytic Polypeptide (PRKDC) interaction partners

  1. Ku80 (show XRCC5 ELISA Kits) is susceptible to proteolytic degradation when not dimerized with Ku70 (show XRCC6 ELISA Kits); dimer induces DNA-PK activity; evidence that interacting domain(s) of Xenopus DNA-PKcs is conserved so as to interact with human Ku, reconstituting a functional holoenzyme

PRKDC Antigen Profile

Antigen Summary

This gene encodes the catalytic subunit of the DNA-dependent protein kinase (DNA-PK). It functions with the Ku70/Ku80 heterodimer protein in DNA double strand break repair and recombination. The protein encoded is a member of the PI3/PI4-kinase family.

Alternative names and synonyms associated with PRKDC

  • protein kinase, DNA-activated, catalytic polypeptide (PRKDC) Elisa Kit
  • protein kinase, DNA activated, catalytic polypeptide (Prkdc) Elisa Kit
  • protein kinase, DNA-activated, catalytic polypeptide (prkdc) Elisa Kit
  • AI326420 Elisa Kit
  • AU019811 Elisa Kit
  • DNA-PKCS Elisa Kit
  • DNAPDcs Elisa Kit
  • dnapk Elisa Kit
  • dnpk1 Elisa Kit
  • DOXNPH Elisa Kit
  • dxnph Elisa Kit
  • hyrc Elisa Kit
  • hyrc1 Elisa Kit
  • p350 Elisa Kit
  • p460 Elisa Kit
  • PRKDC Elisa Kit
  • prkdc-A Elisa Kit
  • scid Elisa Kit
  • slip Elisa Kit
  • xrcc7 Elisa Kit

Protein level used designations for PRKDC

protein kinase, DNA-activated, catalytic polypeptide , protein kinase catalytic subunit (DNA-dependent protein kinase) , DNA-dependent protein kinase catalytic subunit , DNA-activated protein kinase catalytic polypeptide , DNA-dependent protein kinase catalytic subunit-like , DNA-PK catalytic subunit , doxorubicin nephropathy , severe combined immunodeficiency , hyper-radiosensitivity of murine scid mutation, complementing 1 , p460 , DNA-PKcs

282003 Bos taurus
418814 Gallus gallus
464165 Pan troglodytes
512740 Bos taurus
100125348 Oryctolagus cuniculus
100224961 Taeniopygia guttata
100399020 Callithrix jacchus
100586225 Nomascus leucogenys
100633457 Amphimedon queenslandica
19090 Mus musculus
5591 Homo sapiens
373602 Xenopus laevis
395376 Gallus gallus
474176 Canis lupus familiaris
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