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DNA-PKcs deficiency caused inefficient DSB repair at later time points post-IR in both conditions. These observations suggest that DNA-PKcs contributes to the fast and slow repair of DSBs by NHEJ.
The SAGA deubiquitinase activity was required for optimal irradiation-induced gammaH2AX (show H2AFX ELISA Kits) formation, and failure to remove H2BK120ub inhibits ATM (show ATM ELISA Kits)- and DNAPK-induced gammaH2AX (show H2AFX ELISA Kits) formation.
functional DNA-PKcs T2609 cluster is required to facilitate telomere leading strand maturation and prevention of genomic instability and cancer development.
TMU-35435 enhances etoposide cytotoxicity by regulating ubiquitin-proteasomal degradation of DNA-PKcs and inhibiting the DNA repair pathway in triple negative breast cancer cells.
DNA-PKcs are required to prevent endogenous DNA damage accumulation throughout the adult brain.
AIM2 (show AIM2 ELISA Kits) reduced Akt (show AKT1 ELISA Kits) activation and tumor burden in colorectal cancer models, while an Akt (show AKT1 ELISA Kits) inhibitor reduced tumor load in Aim2 (show AIM2 ELISA Kits)(-/-) mice
PRKDC proteins that mediate non-homologous end joining have been identified as TRIP13 (show TRIP13 ELISA Kits) binding partners in head and neck cancer.
NR5A1 (show NR5A1 ELISA Kits) prevents centriole splitting by inhibiting centrosomal DNA-PK activation and beta-catenin (show CTNNB1 ELISA Kits) accumulation
Results show that DNA-PKcs functions as a selective modulator of transcriptional networks that induce cell migration, invasion, and metastasis of prostate cancer cells.
These experiments define a novel requirement for 53BP1 (show TP53BP1 ELISA Kits) in the fusions of DNA-PKcs-deficient telomeres throughout the cell cycle.
KU80 (show XRCC5 ELISA Kits) was found to bind near the proposed BRCA1 binding site, suggesting that KU80 (show XRCC5 ELISA Kits) and BRCA1 may compete for binding to DNA-PKcs. The determination of the crystal structure of DNA-PKcs provides insight into the regulation of its activity and suggests a mechanism for the selection of NHEJ or HR
this study has solved the PRKDC structure in complex with the C-terminal peptide of Ku80 (show XRCC5 ELISA Kits) at 4.3 angstrom resolution using x-ray crystallography.
DNA-PKcs, which is integral to the non-homologous end joining pathway, negatively regulates ATM (show ATM ELISA Kits) activity through phosphorylation of ATM (show ATM ELISA Kits).
that EZH2 (show EZH2 ELISA Kits) is phosphorylated by the DNA damage responsive complex DNA-PK and regulates DNA damage-mediated T-cell apoptosis.
DNA-PKcs is a potent regulator of IL-2 (show IL2 ELISA Kits) production in T lymphocytes.
DNA-PK directly phosphorylates hSSB1 (show SSBP1 ELISA Kits) at serine residue 134. While this modification is largely suppressed in undamaged cells by PPP-family protein phosphatases, S134 phosphorylation is enhanced following the disruption of replication forks and promotes cellular survival.
DNA-PK activity in peripheral blood lymphocytes might be a useful marker for predicting prostate-specific antigen relapse and urinary toxicity, possibly contributing to personalized treatment of prostate cancer.
Data suggest that the model can replicate amplified p53 (show TP53 ELISA Kits) responses under DNA-PK inhibition and provide insights into cell fate decision by manipulating p53 (show TP53 ELISA Kits) dynamics.
These studies clarify the role of PKCdelta (show PKCd ELISA Kits) in endothelial cell cytoskeleton regulation.
Ku80 (show XRCC5 ELISA Kits) is susceptible to proteolytic degradation when not dimerized with Ku70 (show XRCC6 ELISA Kits); dimer induces DNA-PK activity; evidence that interacting domain(s) of Xenopus DNA-PKcs is conserved so as to interact with human Ku, reconstituting a functional holoenzyme
This gene encodes the catalytic subunit of the DNA-dependent protein kinase (DNA-PK). It functions with the Ku70/Ku80 heterodimer protein in DNA double strand break repair and recombination. The protein encoded is a member of the PI3/PI4-kinase family.
DNA-PK catalytic subunit
, DNA-dependent protein kinase catalytic subunit
, hyper-radiosensitivity of murine scid mutation, complementing 1
, protein kinase, DNA-activated, catalytic polypeptide
, protein kinase catalytic subunit (DNA-dependent protein kinase)
, DNA-activated protein kinase catalytic polypeptide
, DNA-dependent protein kinase catalytic subunit-like
, doxorubicin nephropathy
, severe combined immunodeficiency