Browse our PRKDC (PRKDC) ELISA Kits

Full name:
Protein Kinase, DNA-Activated, Catalytic Polypeptide ELISA Kits (PRKDC)
On www.antibodies-online.com are 9 Protein Kinase, DNA-Activated, Catalytic Polypeptide (PRKDC) ELISA Kits from 5 different suppliers available. Additionally we are shipping PRKDC Antibodies (421) and PRKDC Proteins (8) and many more products for this protein. A total of 446 PRKDC products are currently listed.
Synonyms:
AI326420, AU019811, DNA-PKCS, DNAPDcs, dnapk, dnpk1, DOXNPH, dxnph, hyrc, hyrc1, p350, p460, PRKDC, prkdc-A, scid, slip, xrcc7
list all ELISA KIts Gene Name GeneID UniProt
PRKDC 19090 P97313
PRKDC 5591 P78527
PRKDC    

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More ELISA Kits for PRKDC Interaction Partners

Mouse (Murine) Protein Kinase, DNA-Activated, Catalytic Polypeptide (PRKDC) interaction partners

  1. The SAGA deubiquitinase activity was required for optimal irradiation-induced gammaH2AX (show H2AFX ELISA Kits) formation, and failure to remove H2BK120ub inhibits ATM (show ATM ELISA Kits)- and DNAPK-induced gammaH2AX (show H2AFX ELISA Kits) formation.

  2. functional DNA-PKcs T2609 cluster is required to facilitate telomere leading strand maturation and prevention of genomic instability and cancer development.

  3. TMU-35435 enhances etoposide cytotoxicity by regulating ubiquitin-proteasomal degradation of DNA-PKcs and inhibiting the DNA repair pathway in triple negative breast cancer cells.

  4. DNA-PKcs are required to prevent endogenous DNA damage accumulation throughout the adult brain.

  5. AIM2 (show AIM2 ELISA Kits) reduced Akt (show AKT1 ELISA Kits) activation and tumor burden in colorectal cancer models, while an Akt (show AKT1 ELISA Kits) inhibitor reduced tumor load in Aim2 (show AIM2 ELISA Kits)(-/-) mice

  6. PRKDC proteins that mediate non-homologous end joining have been identified as TRIP13 (show TRIP13 ELISA Kits) binding partners in head and neck cancer.

  7. NR5A1 (show NR5A1 ELISA Kits) prevents centriole splitting by inhibiting centrosomal DNA-PK activation and beta-catenin (show CTNNB1 ELISA Kits) accumulation

  8. Results show that DNA-PKcs functions as a selective modulator of transcriptional networks that induce cell migration, invasion, and metastasis of prostate cancer cells.

  9. These experiments define a novel requirement for 53BP1 (show TP53BP1 ELISA Kits) in the fusions of DNA-PKcs-deficient telomeres throughout the cell cycle.

  10. data suggest that DNA-PKcs-SIN1 (show MAPKAP1 ELISA Kits) complexation-mediated Akt (show AKT1 ELISA Kits) activation (Ser (show SIGLEC1 ELISA Kits)-473 phosphorylation) is required for mouse osteoblast differentiation

Human Protein Kinase, DNA-Activated, Catalytic Polypeptide (PRKDC) interaction partners

  1. that EZH2 (show EZH2 ELISA Kits) is phosphorylated by the DNA damage responsive complex DNA-PK and regulates DNA damage-mediated T-cell apoptosis.

  2. DNA-PKcs is a potent regulator of IL-2 (show IL2 ELISA Kits) production in T lymphocytes.

  3. TMU-35435 enhances etoposide cytotoxicity by regulating ubiquitin-proteasomal degradation of DNA-PKcs and inhibiting the DNA repair pathway in triple negative breast cancer cells.

  4. DNA-PK directly phosphorylates hSSB1 (show SSBP1 ELISA Kits) at serine residue 134. While this modification is largely suppressed in undamaged cells by PPP-family protein phosphatases, S134 phosphorylation is enhanced following the disruption of replication forks and promotes cellular survival.

  5. DNA-PK activity in peripheral blood lymphocytes might be a useful marker for predicting prostate-specific antigen relapse and urinary toxicity, possibly contributing to personalized treatment of prostate cancer.

  6. Data suggest that the model can replicate amplified p53 (show TP53 ELISA Kits) responses under DNA-PK inhibition and provide insights into cell fate decision by manipulating p53 (show TP53 ELISA Kits) dynamics.

  7. These studies clarify the role of PKCdelta (show PKCd ELISA Kits) in endothelial cell cytoskeleton regulation.

  8. T204 was identified as a main target for ATM (show ATM ELISA Kits)/DNA-PKcs phosphorylation on human POLL, and this phosphorylation may facilitate the repair of a subset of IR-induced DSBs and the efficient POLL-mediated gap-filling during NHEJ. POLL phosphorylation might favor POLL interaction with the DNA-PK complex at DSBs.

  9. DNA-PKcs inhibitor acriflavine exerts a p53 (show TP53 ELISA Kits)-dependent synergistic efficacy with melphalan against human cancer cells both in vitro and in vivo.

  10. EBV-LMP1 (show PDLIM7 ELISA Kits) suppresses the DNA damage response through DNA-PK/AMPK (show PRKAA1 ELISA Kits) signaling to promote radioresistance in nasopharyngeal carcinoma.

Xenopus laevis Protein Kinase, DNA-Activated, Catalytic Polypeptide (PRKDC) interaction partners

  1. Ku80 (show XRCC5 ELISA Kits) is susceptible to proteolytic degradation when not dimerized with Ku70 (show XRCC6 ELISA Kits); dimer induces DNA-PK activity; evidence that interacting domain(s) of Xenopus DNA-PKcs is conserved so as to interact with human Ku, reconstituting a functional holoenzyme

PRKDC Antigen Profile

Antigen Summary

This gene encodes the catalytic subunit of the DNA-dependent protein kinase (DNA-PK). It functions with the Ku70/Ku80 heterodimer protein in DNA double strand break repair and recombination. The protein encoded is a member of the PI3/PI4-kinase family.

Alternative names and synonyms associated with PRKDC

  • protein kinase, DNA-activated, catalytic polypeptide (PRKDC) Elisa Kit
  • protein kinase, DNA activated, catalytic polypeptide (Prkdc) Elisa Kit
  • protein kinase, DNA-activated, catalytic polypeptide (prkdc) Elisa Kit
  • AI326420 Elisa Kit
  • AU019811 Elisa Kit
  • DNA-PKCS Elisa Kit
  • DNAPDcs Elisa Kit
  • dnapk Elisa Kit
  • dnpk1 Elisa Kit
  • DOXNPH Elisa Kit
  • dxnph Elisa Kit
  • hyrc Elisa Kit
  • hyrc1 Elisa Kit
  • p350 Elisa Kit
  • p460 Elisa Kit
  • PRKDC Elisa Kit
  • prkdc-A Elisa Kit
  • scid Elisa Kit
  • slip Elisa Kit
  • xrcc7 Elisa Kit

Protein level used designations for PRKDC

protein kinase, DNA-activated, catalytic polypeptide , protein kinase catalytic subunit (DNA-dependent protein kinase) , DNA-dependent protein kinase catalytic subunit , DNA-activated protein kinase catalytic polypeptide , DNA-dependent protein kinase catalytic subunit-like , DNA-PK catalytic subunit , doxorubicin nephropathy , severe combined immunodeficiency , hyper-radiosensitivity of murine scid mutation, complementing 1 , p460 , DNA-PKcs

GENE ID SPECIES
282003 Bos taurus
418814 Gallus gallus
464165 Pan troglodytes
512740 Bos taurus
100125348 Oryctolagus cuniculus
100224961 Taeniopygia guttata
100399020 Callithrix jacchus
100586225 Nomascus leucogenys
100633457 Amphimedon queenslandica
19090 Mus musculus
5591 Homo sapiens
373602 Xenopus laevis
395376 Gallus gallus
474176 Canis lupus familiaris
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