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PRKDC Products

(Protein Kinase, DNA-Activated, Catalytic Polypeptide (PRKDC))

Categories

This gene encodes the catalytic subunit of the DNA-dependent protein kinase (DNA-PK). It functions with the Ku70/Ku80 heterodimer protein in DNA double strand break repair and recombination. The protein encoded is a member of the PI3/PI4-kinase family.[provided by RefSeq, Jul 2010].

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Featured PRKDC Categories

PRKDC Antibodies

High quality antibodies with extensive validation data.

PRKDC ELISA Kits

Reliable ELISA kits for a wide range of species.

PRKDC Proteins

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended PRKDC Antibodies

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Application ICC, IHC, ELISA, WB
Validations
  • (2)
  • (5)
Cat. No. ABIN969366
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application IF, IHC (p), ELISA, WB
Validations
  • (1)
  • (5)
Cat. No. ABIN519209
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Application EIA, IF, IHC (p), WB
Validations
  • (5)
Cat. No. ABIN1107001
Quantity 0.1 mL
Datasheet Datasheet

Recommended PRKDC ELISA Kits

Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity Mouse
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
Cat. No. ABIN6958940
Quantity 96 tests
Datasheet Datasheet
Reactivity Human, Mouse
Analytical Method Qualitative Cell ELISA
Validations
Cat. No. ABIN1381086
Quantity 96 tests
Datasheet Datasheet
Reactivity Human
Analytical Method
Validations
Cat. No. ABIN1130280
Quantity 96 tests
Datasheet Datasheet

Recommended PRKDC Proteins

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
  • (1)
Cat. No. ABIN1316293
Quantity 10 μg
Datasheet Datasheet
Reactivity Mouse
Source Escherichia coli (E. coli)
Validations
  • (1)
Cat. No. ABIN5710145
Quantity 100 μg
Datasheet Datasheet
Reactivity Mouse
Source Escherichia coli (E. coli)
Validations
Cat. No. ABIN7087711
Quantity 50 μg
Datasheet Datasheet

Latest Publications for our PRKDC products

Ugidos, Mena, Baquero, Alloza, Azkargorta, Elortza, Vandenbroeck: "Interactome of the Autoimmune Risk Protein ANKRD55." in: Frontiers in immunology, Vol. 10, pp. 2067, (2019) (PubMed).

Biehs, Steinlage, Barton, Juhász, Künzel, Spies, Shibata, Jeggo, Löbrich: "DNA Double-Strand Break Resection Occurs during Non-homologous End Joining in G1 but Is Distinct from Resection during Homologous Recombination." in: Molecular cell, Vol. 65, Issue 4, pp. 671-684.e5, (2017) (PubMed).

Ha, Ma, Lin, Tang, Lian, Zhao, Li, Zhen, Pei, Han, Malumbres, Jin, Chen, Zhao, Zhu, Zhang: "The anaphase promoting complex impacts repair choice by protecting ubiquitin signalling at DNA damage sites." in: Nature communications, Vol. 8, pp. 15751, (2017) (PubMed).

Li, Zhang, Chen, Guo, Zhang, Tang, Xu, Zhang, Tao, Wang, Jiang, Sun, Mao: "Impaired DNA double-strand break repair contributes to the age-associated rise of genomic instability in humans." in: Cell death and differentiation, Vol. 23, Issue 11, pp. 1765-1777, (2017) (PubMed).

Fantini, Huang, Asara, Bagchi, Raychaudhuri: "Chromatin association of XRCC5/6 in the absence of DNA damage depends on the XPE gene product DDB2." in: Molecular biology of the cell, Vol. 28, Issue 1, pp. 192-200, (2016) (PubMed).

Sun, Cheng, Zhu, Zhang, Liu, Xu, Sun, Lv: "Identification of PRKDC (Protein Kinase, DNA-Activated, Catalytic Polypeptide) as an essential gene for colorectal cancer (CRCs) cells." in: Gene, Vol. 584, Issue 1, pp. 90-6, (2016) (PubMed).

Berard, Coombs, Severini: "Quantification of the host response proteome after herpes simplex virus type 1 infection." in: Journal of proteome research, Vol. 14, Issue 5, pp. 2121-42, (2015) (PubMed).

Pyun, Seo, Lee, Jin, Kim, Kim, Kim, Nam, Yook, Lee: "Mutual regulation between DNA-PKcs and Snail1 leads to increased genomic instability and aggressive tumor characteristics." in: Cell death & disease, Vol. 4, pp. e517, (2013) (PubMed).

Schuler, Rübe: "Accumulation of DNA damage-induced chromatin alterations in tissue-specific stem cells: the driving force of aging?" in: PLoS ONE, Vol. 8, Issue 5, pp. e63932, (2013) (PubMed).

Lorat, Schanz, Schuler, Wennemuth, Rübe, Rübe: "Beyond repair foci: DNA double-strand break repair in euchromatic and heterochromatic compartments analyzed by transmission electron microscopy." in: PLoS ONE, Vol. 7, Issue 5, pp. e38165, (2012) (PubMed).

Synonyms and alternative names related to PRKDC

protein kinase, DNA-activated, catalytic polypeptide (PRKDC), protein kinase, DNA-activated, catalytic polypeptide L homeolog (prkdc.L), DNA-dependent protein kinase catalytic subunit (LOC100633457), protein kinase, DNA activated, catalytic polypeptide (Prkdc), AI326420, AU019811, DNA-PKcs, DNA-PKCS, dna-pkcs, DNAPDcs, DNAPK, dnapk, DNPK1, dnpk1, DOXNPH, dxnph, HYRC, hyrc, HYRC1, hyrc1, p350, p460, PRKDC, prkdc-A, scid, slip, XRCC7, xrcc7

Protein level used designations for PRKDC

  • DNA-PK catalytic subunit
  • DNA-dependent protein kinase catalytic subunit
  • hyper-radiosensitivity of murine scid mutation, complementing 1
  • p460
  • protein kinase, DNA-activated, catalytic polypeptide
  • DNA-PKcs
  • protein kinase catalytic subunit (DNA-dependent protein kinase)
  • DNA-activated protein kinase catalytic polypeptide
  • DNA-dependent protein kinase catalytic subunit-like
  • doxorubicin nephropathy
  • severe combined immunodeficiency
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