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porcine FZR1 and CDC20 (show CDC20 Proteins) work on the maintenance of meiotic arrest at the first meiotic prophase and on the exit from M1
CHD1 loss is associated with an increased sensitivity to PARP inhibition and anti-cancer drugs that induce DNA intercross-strand links in prostate tumors.
APC (show APC Proteins)/C and pRB (show RB1 Proteins) interact with each other via the co-activator of APC (show APC Proteins)/C, FZR1, providing an alternative pathway of regulation of G1 to S transition by pRB (show RB1 Proteins) using a post-translational mechanism. Both pRB (show RB1 Proteins) and FZR1 have complex roles and are implicated not only in regulation of cell proliferation but also in differentiation, quiescence, apoptosis, maintenance of chromosomal integrity and metabolism.
FZR1 inhibits BRAF (show BRAF Proteins) oncogenic functions via both APC (show APC Proteins)-dependent proteolysis and APC (show APC Proteins)-independent disruption of BRAF (show BRAF Proteins) dimers, whereas hyperactivated ERK (show EPHB2 Proteins) and CDK4 (show CDK4 Proteins) reciprocally suppress APC (show APC Proteins)(FZR1) E3 ligase activity
These findings identify a dynamic interplay between FZR1 and BRAF (show BRAF Proteins) with strong implications for cell-fate determination and the tumor suppressor role of FZR1
results suggest that reduction of FZR1 increases therapeutic sensitivity of B-ALL and that transient rather than tonic inhibition of FZR1 may be a therapeutic strategy.
results define a new APC (show APC Proteins)/C(Cdh1 (show CDH1 Proteins)) function that prevents cell cycle resumption after prolonged replication stress by inhibiting origin firing, which may act as an additional mechanism in safeguarding genome integrity.
APC (show APC Proteins)(Cdh1 (show CDH1 Proteins)) inactivation is the commitment point when cells lose the ability to return to quiescence and decide to progress through the cell cycle.
Data show that CDC20 (show CDC20 Proteins) homolog 1 (Cdh1 (show CDH1 Proteins)) is O-GlcNAcylated in cultured cells.
Cdh1 (show CDH1 Proteins) contributes to spatiotemporal organization of AurB (show AURKB Proteins) activity, and organization of FHOD1 (show FHOD1 Proteins) activity by AurB (show AURKB Proteins) contributes to daughter cell spreading after mitosis.
Anaphase-promoting complex/cyclosome-CDH1 (show CDH1 Proteins), rather than Cdc20 (show CDC20 Proteins), promotes the degradation of BRSK2 (show BRSK2 Proteins) in vivo.
CHD1 loss is associated with an increased sensitivity to PARP (show PARP1 Proteins) inhibition and anti-cancer drugs that induce DNA intercross-strand links in prostate tumors.
loss of Cdh1 (show CDH1 Proteins) leads to increased and extended S phase progression possibly due to the upregulation of cyclin D1 (show CCND1 Proteins).
Both catalytic and non-catalytic APC (show APC Proteins)/C-Fzr1/Cdh1-mediated activities of PTEN are required for stalk cells' proliferative arrest. Findings implicate the PTEN-APC (show APC Proteins)/C-Fzr1/Cdh1 hub in angiogenesis.
Loss of APC (show APC Proteins)/C(FZR1) activity in the male germline led to both a mitotic and a meiotic testicular defect resulting in infertility due to the absence of mature spermatozoa.
Fzr1 is a surprisingly essential gene involved in the establishment of a single spindle from the two pronuclei in 1-cell embryos as well as being involved in the maintenance of genomic integrity during the mitotic divisions of early mammalian embryos.
This study implicates FZR1 as a major regulator of prometaphase whose activity helps to prevent chromosome nondisjunction.
When a neuronal cell enters S phase, Cdk5 (show CDK5 Proteins) is transported to the cytoplasm where it is ubiquitinated by the E3 ligase APC (show APC Proteins)-Cdh1 (show CDH1 Proteins)
Cdh1 (show CDH1 Proteins)-APC (show APC Proteins) appears to play a role in regulating axonal growth and patterning in the developing brain that may also limit the growth of injured axons in the adult brain.
FZR1 activity is required to repress cyclin B1 (show CCNB1 Proteins) levels in oocytes during prophase I arrest in the ovary, thereby maintaining meiotic quiescence until hormonal cues trigger resumption
Key regulator of ligase activity of the anaphase promoting complex/cyclosome (APC/C), which confers substrate specificity upon the complex. Associates with the APC/C in late mitosis, in replacement of CDC20, and activates the APC/C during anaphase and telophase. The APC/C remains active in degrading substrates to ensure that positive regulators of the cell cycle do not accumulate prematurely. At the G1/S transition FZR1 is phosphorylated, leading to its dissociation from the APC/C. Following DNA damage, it is required for the G2 DNA damage leads to the ubiquitination of PLK1, preventing entry into mitosis (By similarity).
fizzy-related protein homolog
, fizzy/cell division cycle 20 related 1 (Drosophila)
, fizzy-related protein FZR
, Fizzy-related protein-like protein
, fizzy/cell division cycle 20 related 1
, CDC20-like 1b
, CDC20-like protein 1
, cdh1/Hct1 homolog
, cell division cycle 20 related 1