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porcine FZR1 and CDC20 (show CDC20 Proteins) work on the maintenance of meiotic arrest at the first meiotic prophase and on the exit from M1
APC (show APC Proteins)(Cdh1 (show CDH1 Proteins)) inactivation is the commitment point when cells lose the ability to return to quiescence and decide to progress through the cell cycle.
Data show that CDC20 (show CDC20 Proteins) homolog 1 (Cdh1 (show CDH1 Proteins)) is O-GlcNAcylated in cultured cells.
Cdh1 (show CDH1 Proteins) contributes to spatiotemporal organization of AurB (show AURKB Proteins) activity, and organization of FHOD1 (show FHOD1 Proteins) activity by AurB (show AURKB Proteins) contributes to daughter cell spreading after mitosis.
Anaphase-promoting complex/cyclosome-CDH1 (show CDH1 Proteins), rather than Cdc20 (show CDC20 Proteins), promotes the degradation of BRSK2 (show BRSK2 Proteins) in vivo.
Anaphase-promoting complex/cyclosome-Cdh1 (show CDH1 Proteins) coordinates glycolysis and glutaminolysis with transition to S phase in human T lymphocytes.
Cdh1-depleted H (show CDH1 Proteins)eLa cells reduced s (show CDH1 Proteins)tress (show FABP6 Proteins)fiber formation significantly. The GTP-bound active Rho protein was apparently decreased in the Cdh1-depleted cells.
FZR1 is not required for the completion of mitosis, but is an important regulator of G1 phase and is required for efficient DNA replication in human and mouse somatic cells.
Destruction-box specificities of APC (show APC Proteins)/C(fzy) and APC (show APC Proteins)/C(fzr)& successive activation of APC (show APC Proteins)/C by fzy & fzr establish the temporal substrate degradation pattern, explaining why some endogenous RXXL substrates are degraded by fzy & others by fzr complexes.
Results indicate that Cdh1 (show CDH1 Proteins) mediates its own degradation by activating the anaphase-promoting complex/cyclosome to degrade itself.
Data show that degradation of TMAP/CKAP2 (show CKAP2 Proteins) during mitotic exit is mediated by the anaphase-promoting complex bound to Cdh1 (show CDH1 Proteins) and that the KEN box motif near the N terminus is necessary for its destruction.
Both catalytic and non-catalytic APC (show APC Proteins)/C-Fzr1/Cdh1-mediated activities of PTEN are required for stalk cells' proliferative arrest. Findings implicate the PTEN-APC (show APC Proteins)/C-Fzr1/Cdh1 hub in angiogenesis.
Loss of APC (show APC Proteins)/C(FZR1) activity in the male germline led to both a mitotic and a meiotic testicular defect resulting in infertility due to the absence of mature spermatozoa.
Fzr1 is a surprisingly essential gene involved in the establishment of a single spindle from the two pronuclei in 1-cell embryos as well as being involved in the maintenance of genomic integrity during the mitotic divisions of early mammalian embryos.
This study implicates FZR1 as a major regulator of prometaphase whose activity helps to prevent chromosome nondisjunction.
When a neuronal cell enters S phase, Cdk5 (show CDK5 Proteins) is transported to the cytoplasm where it is ubiquitinated by the E3 ligase APC (show APC Proteins)-Cdh1 (show CDH1 Proteins)
Cdh1 (show CDH1 Proteins)-APC (show APC Proteins) appears to play a role in regulating axonal growth and patterning in the developing brain that may also limit the growth of injured axons in the adult brain.
FZR1 activity is required to repress cyclin B1 (show CCNB1 Proteins) levels in oocytes during prophase I arrest in the ovary, thereby maintaining meiotic quiescence until hormonal cues trigger resumption
homozygous Cdh1 (show CDH1 Proteins) gene-trapped (Cdh1 (show CDH1 Proteins)(GT/GT (show FABP6 Proteins)))embryonic fibroblasts reduced stress fiber formation significantly
These results indicate that Cdh1 (show CDH1 Proteins) is required for preventing unscheduled proliferation of specific progenitor cells and protecting mammalian cells from genomic instability.
Depletion of FZR1 (CDH1), a regulatory subunit of the anaphase-promoting complex/cyclosome that targets cyclin B1 (CCNB1 (show CCNB1 Proteins)) for ubiquitin-mediated proteolysis, partially restores normal timing of meiotic resumption in oocytes with excess CDC14B (show CDC14B Proteins).
Key regulator of ligase activity of the anaphase promoting complex/cyclosome (APC/C), which confers substrate specificity upon the complex. Associates with the APC/C in late mitosis, in replacement of CDC20, and activates the APC/C during anaphase and telophase. The APC/C remains active in degrading substrates to ensure that positive regulators of the cell cycle do not accumulate prematurely. At the G1/S transition FZR1 is phosphorylated, leading to its dissociation from the APC/C. Following DNA damage, it is required for the G2 DNA damage leads to the ubiquitination of PLK1, preventing entry into mitosis (By similarity).
fizzy-related protein homolog
, fizzy/cell division cycle 20 related 1 (Drosophila)
, fizzy-related protein FZR
, Fizzy-related protein-like protein
, fizzy/cell division cycle 20 related 1
, CDC20-like 1b
, CDC20-like protein 1
, cdh1/Hct1 homolog
, cell division cycle 20 related 1