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gbx2 not only functions to position the midbrain-hindbrain boundary but also regulates neurogenesis in the anterior hindbrain.
Gbx2 functions as a transcriptional repressor to regulate the specification and morphogenesis of the mid-hindbrain junction in a dosage- and stage-dependent manner.
in the zebrafish gbx1 and gbx2 are required redundantly for morphogenesis of the cerebellar primordium and subsequent cerebellar differentiation, but that this requirement is alleviated by knocking down Otx
gbx2/Gbx2 has an evolutionarily conserved role in anterior hindbrain development.
Here we report the isolation, mapping, chromosomal synteny and spatiotemporal expression of gbx1 and gbx2 in zebrafish. We focus in particular on the expression of these genes during development of the midbrain-hindbrain territory.
Ectopic expression of gbx2 by mRNA injection caused cyclopia or truncation of the fore- and midbrain and severely affected isthmic and cerebellar structures.
gbx2 expression during the somitogenesis stage in zebrafish is regulated by a complex mechanism involving Pax2 (show PAX2 Proteins) as well as activators and suppressors in the regions flanking the gene.
Data established a seven-gene (AR, ESR2 (show ESR2 Proteins), GATA3 (show GATA3 Proteins), GBX2, KRT16 (show KRT16 Proteins), MMP28 (show MMP28 Proteins) and WNT11 (show WNT11 Proteins)) prognostic signature to define a subset of triple-negative breast cancer (TNBC).
Gbx2 and Otx2 (show OTX2 Proteins) interact with the WD40 domain (show DCAF12L2 Proteins) of Groucho/Tle corepressors
Functional studies indicated that Klf4 (show KLF4 Proteins) mediates the self-renewal-promoting effects of Gbx2, because knockdown of Klf4 (show KLF4 Proteins) expression abrogated the ability of Gbx2 to maintain the undifferentiated state of mESCs.
Deregulated FGF8 (show FGF8 Proteins) and Otx2 (show OTX2 Proteins)/Gbx2 gene expression underlies cerebellar vermis hypoplasia in mouse model of CHARGE syndrome.
Gbx2 is essential for the acquisition of the thalamic neuronal identity by repressing habenular identity through a feedback signaling from postmitotic neurons to progenitors
Results reveal a novel function of Gbx2 in mESC reprogramming and LIF (show LIF Proteins)/Stat3 (show STAT3 Proteins)-mediated self-renewal.
Results indicate that the dynamic expression of Gbx2 may act as an important determinant in coupling with other developmental programs to generate distinct thalamic nuclei.
Identified are several GBX2 candidate target genes including ROBO1 (show ROBO1 Proteins), PLXNA4 (show PLXNA4 Proteins), SLIT3 (show SLIT3 Proteins), NRP1 (show NRP1 Proteins), PCDH15 (show PCDH15 Proteins), USH2A, NOTCH2 (show NOTCH2 Proteins), and EEF1A1 (show EEF1A1 Proteins) that are likely to contribute many of the developmental defects observed in Gbx2 mutant organisms.
Gbx2 regulates thalamocortical axon guidance by modifying the LIM (show PDLIM5 Proteins) and Robo codes.
the Gbx2 homeodomain recognizes the target TAATTA in the FM enhancer, and Gbx2 associates with the FM enhancer in the hindbrain
long-term lineage analysis reveals that the presence and timing of Gbx2 expression in interneuron progenitors results in the differential contribution to subtypes of terminally differentiated interneurons in the adult spinal cord
May act as a transcription factor for cell pluripotency and differentiation in the embryo.
homeobox protein GBX-2
, gastrulation brain homeobox 2
, gastrulation brain homeo box 2
, gastrulation and brain-specific homeobox protein 2
, stimulated by retinoic acid gene 7 protein
, homeobox protein Xgbx-2